CHEMICAL SYNTHESIS AND ANTICANCER AND ANTIMETASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE
FIELD: chemistry.SUBSTANCE: invention relates to dual functional conjugate of formula i, where docetaxel is linked with muramyl dipeptide derivative, which enables to achieve anticancer and antimetastatic effect. Method of producing conjugate is carried out by combination of solid-phase and liquid-p...
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| creator | MA JAo LJU Gan CHZHAO Nan |
| description | FIELD: chemistry.SUBSTANCE: invention relates to dual functional conjugate of formula i, where docetaxel is linked with muramyl dipeptide derivative, which enables to achieve anticancer and antimetastatic effect. Method of producing conjugate is carried out by combination of solid-phase and liquid-phase synthesis.EFFECT: invention also discloses a pharmaceutical composition and use of conjugate for producing anti-tumour drugs.21 cl, 29 dwg, 13 tbl, 51 ex
Изобретение относится к конъюгату двойного действия формулы I, в котором доцетаксел связан с производным мурамилдипептида, что обеспечивает достижение противоопухолевого и противометастатического эффекта. Способ получения конъюгата осуществляют путем комбинации твердофазного и жидкофазного синтеза. Также предложены фармацевтическая композиция и применение конъюгата для получения противоопухолевых лекарственных средств. 4 н. и 17 з.п. ф-лы, 29 ил., 13 табл., 51 пр. |
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Изобретение относится к конъюгату двойного действия формулы I, в котором доцетаксел связан с производным мурамилдипептида, что обеспечивает достижение противоопухолевого и противометастатического эффекта. Способ получения конъюгата осуществляют путем комбинации твердофазного и жидкофазного синтеза. Также предложены фармацевтическая композиция и применение конъюгата для получения противоопухолевых лекарственных средств. 4 н. и 17 з.п. ф-лы, 29 ил., 13 табл., 51 пр.</description><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161210&DB=EPODOC&CC=RU&NR=2604718C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161210&DB=EPODOC&CC=RU&NR=2604718C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MA JAo</creatorcontrib><creatorcontrib>LJU Gan</creatorcontrib><creatorcontrib>CHZHAO Nan</creatorcontrib><title>CHEMICAL SYNTHESIS AND ANTICANCER AND ANTIMETASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE</title><description>FIELD: chemistry.SUBSTANCE: invention relates to dual functional conjugate of formula i, where docetaxel is linked with muramyl dipeptide derivative, which enables to achieve anticancer and antimetastatic effect. Method of producing conjugate is carried out by combination of solid-phase and liquid-phase synthesis.EFFECT: invention also discloses a pharmaceutical composition and use of conjugate for producing anti-tumour drugs.21 cl, 29 dwg, 13 tbl, 51 ex
Изобретение относится к конъюгату двойного действия формулы I, в котором доцетаксел связан с производным мурамилдипептида, что обеспечивает достижение противоопухолевого и противометастатического эффекта. Способ получения конъюгата осуществляют путем комбинации твердофазного и жидкофазного синтеза. Также предложены фармацевтическая композиция и применение конъюгата для получения противоопухолевых лекарственных средств. 4 н. и 17 з.п. ф-лы, 29 ил., 13 табл., 51 пр.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIh09nD19XR29FEIjvQL8XAN9gxWcPRzAeIQoKifs2sQnOvrGuIYHOIIFFdwdXNzdQ4JVvB3U3AJBep1C_VzDvH09wMynf39vELdHUNceRhY0xJzilN5oTQ3g4Kba4izh25qQX58anFBYnJqXmpJfFCokZmBibmhhbORMRFKALguMTE</recordid><startdate>20161210</startdate><enddate>20161210</enddate><creator>MA JAo</creator><creator>LJU Gan</creator><creator>CHZHAO Nan</creator><scope>EVB</scope></search><sort><creationdate>20161210</creationdate><title>CHEMICAL SYNTHESIS AND ANTICANCER AND ANTIMETASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE</title><author>MA JAo ; LJU Gan ; CHZHAO Nan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2604718C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MA JAo</creatorcontrib><creatorcontrib>LJU Gan</creatorcontrib><creatorcontrib>CHZHAO Nan</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MA JAo</au><au>LJU Gan</au><au>CHZHAO Nan</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CHEMICAL SYNTHESIS AND ANTICANCER AND ANTIMETASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE</title><date>2016-12-10</date><risdate>2016</risdate><abstract>FIELD: chemistry.SUBSTANCE: invention relates to dual functional conjugate of formula i, where docetaxel is linked with muramyl dipeptide derivative, which enables to achieve anticancer and antimetastatic effect. Method of producing conjugate is carried out by combination of solid-phase and liquid-phase synthesis.EFFECT: invention also discloses a pharmaceutical composition and use of conjugate for producing anti-tumour drugs.21 cl, 29 dwg, 13 tbl, 51 ex
Изобретение относится к конъюгату двойного действия формулы I, в котором доцетаксел связан с производным мурамилдипептида, что обеспечивает достижение противоопухолевого и противометастатического эффекта. Способ получения конъюгата осуществляют путем комбинации твердофазного и жидкофазного синтеза. Также предложены фармацевтическая композиция и применение конъюгата для получения противоопухолевых лекарственных средств. 4 н. и 17 з.п. ф-лы, 29 ил., 13 табл., 51 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CHEMICAL SYNTHESIS AND ANTICANCER AND ANTIMETASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE |
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