QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING SAME

FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry, namely to a heterocyclic compound of general formula (I) or its pharmaceutically acceptable salt thereof, where: Ris C-Calkyl sulphonyl or -CO-R, where Ris C-C-alkyl or C-Ccycloalkyl; Rrepresents phenyl which can contain group substitute selected from group of substitutes C, or -NRR, where Ris hydrogen atom and Ris -(CH)-R(where n equals whole number from 0 to 2 and Rrepresents mono- or tricyclic C-Ccycloalkyl, which can contain group substitute selected from group of substitutes D, phenyl, which can contain group substitute selected from a group of substitutes E, aliphatic heterocyclic group which is selected from piperidinil, piperazinil and azabicyclooctanil and can be substituted C-C-alkyl, aromatic heterocyclic group which is selected from a pyridinyl, pyrimidinyl and pirazolil and can contain group substitute selected from a group of substitutes I), or Rand Ris formed with adjacent nitrogen atom aliphatic heterocyclic group that is selected from piperidinil and piperazinil and may contain group substitute selected from a group of substitutes F; Ris C-Caryl, which can contain group substitute selected from a group of substitutes G, or aromatic heterocyclic group which is selected from a pyridinyl, pyrimidinyl, tiofenil, isoxazolyl, pyrrolyl and pirazolil and can contain group substitute selected from a group of substitutes H; Ris hydrogen atom or halogen; R is hydrogen atom or halogen; and Ris hydrogen atom; where said substitutes C - I are one-three substitutes are given in claim. Invention also relates to pharmaceutical composition, an inhibitor of MELK, agent, which simulates the expression MELK, anticancer agent based on compounds of formula (I), method of treating and/or preventing diseases, which includes MELK overexpression, using compound of formula (I).EFFECT: obtained are novel heterocyclic compounds effective as anti-tumour agent.19 cl, 4 tbl, 1200 ex Изобретение относится к области органической химии, а именно к гетероциклическому соединению общей формулы (I) или к его фармацевтически приемлемой соли, где: Rпредставляет собой C-Cалкилсульфонил или -CO-R, где Rпредставляет собой C-Cалкил или С-Сциклоалкил; Rпредставляет собой фенил, который может содержать группу заместителя, выбранную из Группы заместителей С, или -NRR, где Rпредставляет собой атом водорода и Rпредставляет собой -(CH)-R(где n равно целому числу от 0 до 2 и Rпредставляет собой моно- или трициклический С-Сци