RECOMBINANT SINGLE-DOMAIN ANTIBODY ABLE TO BIND HUMAN TUMOUR NECROSIS FACTOR SPECIFICALLY AND ITS DERIVATIVES
FIELD: medicine.SUBSTANCE: invention refers to immunology and biotechnology. What is presented is a single-domain antibody (VHH) able to bind the cytokine human necrosis factor (TNF), a DNA fragment coding the antibody according to the invention, as well as a method for identifying the human TNF and...
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| creator | DRUTSKAJA MARINA SERGEEVNA NEDOSPASOV SERGEJ ARTUROVICH TILLIB SERGEJ VLADIMIROVICH EFIMOV GRIGORIJ ALEKSANDROVICH KRUGLOV ANDREJ ALEKSEEVICH |
| description | FIELD: medicine.SUBSTANCE: invention refers to immunology and biotechnology. What is presented is a single-domain antibody (VHH) able to bind the cytokine human necrosis factor (TNF), a DNA fragment coding the antibody according to the invention, as well as a method for identifying the human TNF and measuring it in a biological sample.EFFECT: invention provides the specific block of macrophague-monocytic TNF cells and can find further application in therapy of the diseases associated with an undesired TNF-dependent inflammatory response.4 cl, 5 ex, 7 dwg
Изобретение относится области иммунологии и биотехнологии. Предложено однодоменное антитело (VHH), способное связывать цитокин фактор некроза опухолей (ФНО, TNF) человека, фрагмент ДНК, кодирующий антитело по изобретению, способ получения антитела по изобретению, а также способ выявления и определения уровня содержания ФНО человека в биологическом образце. Настоящее изобретение обеспечивает специфическую блокировку ФНО клеток макрофагально-моноцитарного ряда и может найти дальнейшее применение в терапии заболеваний, связанных с нежелательным ФНО-зависимым воспалительным ответом. 4 н.п. ф-лы, 5 пр., 7 ил. |
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Изобретение относится области иммунологии и биотехнологии. Предложено однодоменное антитело (VHH), способное связывать цитокин фактор некроза опухолей (ФНО, TNF) человека, фрагмент ДНК, кодирующий антитело по изобретению, способ получения антитела по изобретению, а также способ выявления и определения уровня содержания ФНО человека в биологическом образце. Настоящее изобретение обеспечивает специфическую блокировку ФНО клеток макрофагально-моноцитарного ряда и может найти дальнейшее применение в терапии заболеваний, связанных с нежелательным ФНО-зависимым воспалительным ответом. 4 н.п. ф-лы, 5 пр., 7 ил.</description><language>eng ; rus</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141010&DB=EPODOC&CC=RU&NR=2530553C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141010&DB=EPODOC&CC=RU&NR=2530553C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DRUTSKAJA MARINA SERGEEVNA</creatorcontrib><creatorcontrib>NEDOSPASOV SERGEJ ARTUROVICH</creatorcontrib><creatorcontrib>TILLIB SERGEJ VLADIMIROVICH</creatorcontrib><creatorcontrib>EFIMOV GRIGORIJ ALEKSANDROVICH</creatorcontrib><creatorcontrib>KRUGLOV ANDREJ ALEKSEEVICH</creatorcontrib><title>RECOMBINANT SINGLE-DOMAIN ANTIBODY ABLE TO BIND HUMAN TUMOUR NECROSIS FACTOR SPECIFICALLY AND ITS DERIVATIVES</title><description>FIELD: medicine.SUBSTANCE: invention refers to immunology and biotechnology. What is presented is a single-domain antibody (VHH) able to bind the cytokine human necrosis factor (TNF), a DNA fragment coding the antibody according to the invention, as well as a method for identifying the human TNF and measuring it in a biological sample.EFFECT: invention provides the specific block of macrophague-monocytic TNF cells and can find further application in therapy of the diseases associated with an undesired TNF-dependent inflammatory response.4 cl, 5 ex, 7 dwg
Изобретение относится области иммунологии и биотехнологии. Предложено однодоменное антитело (VHH), способное связывать цитокин фактор некроза опухолей (ФНО, TNF) человека, фрагмент ДНК, кодирующий антитело по изобретению, способ получения антитела по изобретению, а также способ выявления и определения уровня содержания ФНО человека в биологическом образце. 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What is presented is a single-domain antibody (VHH) able to bind the cytokine human necrosis factor (TNF), a DNA fragment coding the antibody according to the invention, as well as a method for identifying the human TNF and measuring it in a biological sample.EFFECT: invention provides the specific block of macrophague-monocytic TNF cells and can find further application in therapy of the diseases associated with an undesired TNF-dependent inflammatory response.4 cl, 5 ex, 7 dwg
Изобретение относится области иммунологии и биотехнологии. Предложено однодоменное антитело (VHH), способное связывать цитокин фактор некроза опухолей (ФНО, TNF) человека, фрагмент ДНК, кодирующий антитело по изобретению, способ получения антитела по изобретению, а также способ выявления и определения уровня содержания ФНО человека в биологическом образце. Настоящее изобретение обеспечивает специфическую блокировку ФНО клеток макрофагально-моноцитарного ряда и может найти дальнейшее применение в терапии заболеваний, связанных с нежелательным ФНО-зависимым воспалительным ответом. 4 н.п. ф-лы, 5 пр., 7 ил.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | RECOMBINANT SINGLE-DOMAIN ANTIBODY ABLE TO BIND HUMAN TUMOUR NECROSIS FACTOR SPECIFICALLY AND ITS DERIVATIVES |
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