METHOD OF PRODUCING ARTIFICIAL OLIGONUCLEOTIDES POTENTIALLY CAPABLE OF FORMING IMPERFECT G-QUADRUPLEXES
FIELD: chemistry.SUBSTANCE: invention relates to biotechnology, specifically a method of producing artificial oligonucleotides that are potentially capable of forming non-canonical structures that stable in physiological conditions and conditions close to physiological, said structures being imperfe...
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| creator | VARIZHUK ANNA MIKHAJLOVNA TATARINOVA OL'GA NIKOLAEVNA ISHCHENKO DMITRIJ STANISLAVOVICH SMIRNOV IGOR' PAVLOVICH POZMOGOVA GALINA EVGEN'EVNA |
| description | FIELD: chemistry.SUBSTANCE: invention relates to biotechnology, specifically a method of producing artificial oligonucleotides that are potentially capable of forming non-canonical structures that stable in physiological conditions and conditions close to physiological, said structures being imperfect G-quadruplexes (lmGQ) which include one nucleotide substitution in the Gplane in the G-quadruplexes (GQ). Said method includes using an algorithm describing nucleotide sequences in form of a defined set of formulae for further synthesis of selected oligonucleotides.EFFECT: invention enables to use bioinformation analysis to obtain artificial oligonucleotides that are potentially capable of forming a new conformation - imperfect G-quadruplexes.4 dwg, 2 tbl, 2 ex
Изобретение относится к области биотехнологии, конкретно к способу получения неприродных искусственных олигонуклеотидов, потенциально способных образовывать стабильные в физиологических и близких к физиологическим условиях неканонические структуры - несовершенные G-квадруплексы (ImGQ), включающие одну нуклеотидную замену в Gплоскости в G-квадруплексах (GQ). Указанный способ включает использование алгоритма описания нуклеотидных последовательностей в виде определенного набора формул для дальнейшего синтеза выбранных олигонуклеотидов. Изобретение позволяет с помощью биоинформационного анализа получать неприродные искусственные олигонуклеотиды, потенциально способные формировать новую конформацию - несовершенные G-квадруплексы. 4 ил., 2 табл., 2 пр. |
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Изобретение относится к области биотехнологии, конкретно к способу получения неприродных искусственных олигонуклеотидов, потенциально способных образовывать стабильные в физиологических и близких к физиологическим условиях неканонические структуры - несовершенные G-квадруплексы (ImGQ), включающие одну нуклеотидную замену в Gплоскости в G-квадруплексах (GQ). Указанный способ включает использование алгоритма описания нуклеотидных последовательностей в виде определенного набора формул для дальнейшего синтеза выбранных олигонуклеотидов. Изобретение позволяет с помощью биоинформационного анализа получать неприродные искусственные олигонуклеотиды, потенциально способные формировать новую конформацию - несовершенные G-квадруплексы. 4 ил., 2 табл., 2 пр.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CALCULATING</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>COMPUTING</subject><subject>COUNTING</subject><subject>CULTURE MEDIA</subject><subject>ELECTRIC DIGITAL DATA PROCESSING</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EKwjAQAHvxIOof9gOFWhH0GDebNpB2Y7oBPZUi0Ytoof4fFXyApznMzDy7NSQ1a2ADPrCOaNsKVBBrLFrlgJ2tuI3oiMVq6sCzUCsf5c6AyquDo-9sODTf1TaegiEUqPJjVDpE7-hE3TKbXYf7lFY_LjIwJFjnaXz2aRqHS3qkVx9iuS32u6LE9eaP5A27ajV-</recordid><startdate>20140320</startdate><enddate>20140320</enddate><creator>VARIZHUK ANNA MIKHAJLOVNA</creator><creator>TATARINOVA OL'GA NIKOLAEVNA</creator><creator>ISHCHENKO DMITRIJ STANISLAVOVICH</creator><creator>SMIRNOV IGOR' PAVLOVICH</creator><creator>POZMOGOVA GALINA EVGEN'EVNA</creator><scope>EVB</scope></search><sort><creationdate>20140320</creationdate><title>METHOD OF PRODUCING ARTIFICIAL OLIGONUCLEOTIDES POTENTIALLY CAPABLE OF FORMING IMPERFECT G-QUADRUPLEXES</title><author>VARIZHUK ANNA MIKHAJLOVNA ; TATARINOVA OL'GA NIKOLAEVNA ; ISHCHENKO DMITRIJ STANISLAVOVICH ; SMIRNOV IGOR' PAVLOVICH ; POZMOGOVA GALINA EVGEN'EVNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2509802C13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2014</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CALCULATING</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>COMPUTING</topic><topic>COUNTING</topic><topic>CULTURE MEDIA</topic><topic>ELECTRIC DIGITAL DATA PROCESSING</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>VARIZHUK ANNA MIKHAJLOVNA</creatorcontrib><creatorcontrib>TATARINOVA OL'GA NIKOLAEVNA</creatorcontrib><creatorcontrib>ISHCHENKO DMITRIJ STANISLAVOVICH</creatorcontrib><creatorcontrib>SMIRNOV IGOR' PAVLOVICH</creatorcontrib><creatorcontrib>POZMOGOVA GALINA EVGEN'EVNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VARIZHUK ANNA MIKHAJLOVNA</au><au>TATARINOVA OL'GA NIKOLAEVNA</au><au>ISHCHENKO DMITRIJ STANISLAVOVICH</au><au>SMIRNOV IGOR' PAVLOVICH</au><au>POZMOGOVA GALINA EVGEN'EVNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF PRODUCING ARTIFICIAL OLIGONUCLEOTIDES POTENTIALLY CAPABLE OF FORMING IMPERFECT G-QUADRUPLEXES</title><date>2014-03-20</date><risdate>2014</risdate><abstract>FIELD: chemistry.SUBSTANCE: invention relates to biotechnology, specifically a method of producing artificial oligonucleotides that are potentially capable of forming non-canonical structures that stable in physiological conditions and conditions close to physiological, said structures being imperfect G-quadruplexes (lmGQ) which include one nucleotide substitution in the Gplane in the G-quadruplexes (GQ). Said method includes using an algorithm describing nucleotide sequences in form of a defined set of formulae for further synthesis of selected oligonucleotides.EFFECT: invention enables to use bioinformation analysis to obtain artificial oligonucleotides that are potentially capable of forming a new conformation - imperfect G-quadruplexes.4 dwg, 2 tbl, 2 ex
Изобретение относится к области биотехнологии, конкретно к способу получения неприродных искусственных олигонуклеотидов, потенциально способных образовывать стабильные в физиологических и близких к физиологическим условиях неканонические структуры - несовершенные G-квадруплексы (ImGQ), включающие одну нуклеотидную замену в Gплоскости в G-квадруплексах (GQ). Указанный способ включает использование алгоритма описания нуклеотидных последовательностей в виде определенного набора формул для дальнейшего синтеза выбранных олигонуклеотидов. Изобретение позволяет с помощью биоинформационного анализа получать неприродные искусственные олигонуклеотиды, потенциально способные формировать новую конформацию - несовершенные G-квадруплексы. 4 ил., 2 табл., 2 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CALCULATING CHEMISTRY COMPOSITIONS THEREOF COMPUTING COUNTING CULTURE MEDIA ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | METHOD OF PRODUCING ARTIFICIAL OLIGONUCLEOTIDES POTENTIALLY CAPABLE OF FORMING IMPERFECT G-QUADRUPLEXES |
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