CELL LINE HUFSHIK RELEASING RECOMBINANT HUMAN FOLLICLE-STIMULATING HORMONE

FIELD: biotechnologies.SUBSTANCE: invention proposes cell line huFSHIK - producer of recombinant human follicle-stimulating hormone (FSH) released to culture liquid. The line releases FSH in suspension culture in concentration of 18IU/10cells a day.EFFECT: invention optimises FSH expression system,...

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Hauptverfasser: PAVLENKO DANIIL MIKHAJLOVICH, KARJAGINA TAT'JANA BORISOVNA, BAIRAMASHVILI DMITRIJ IL'ICH, GUKASOVA ELENA ALEKSANDROVNA, OREKHOVA NATAL'JA EVGEN'EVNA, POLZIKOV MIKHAIL ALEKSANDROVICH, KIRILLOVA IRINA VIKTOROVNA
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creator PAVLENKO DANIIL MIKHAJLOVICH
KARJAGINA TAT'JANA BORISOVNA
BAIRAMASHVILI DMITRIJ IL'ICH
GUKASOVA ELENA ALEKSANDROVNA
OREKHOVA NATAL'JA EVGEN'EVNA
POLZIKOV MIKHAIL ALEKSANDROVICH
KIRILLOVA IRINA VIKTOROVNA
description FIELD: biotechnologies.SUBSTANCE: invention proposes cell line huFSHIK - producer of recombinant human follicle-stimulating hormone (FSH) released to culture liquid. The line releases FSH in suspension culture in concentration of 18IU/10cells a day.EFFECT: invention optimises FSH expression system, which leads to increase of its products and improvement of efficiency and cost effectiveness of FSH production for medical purpose.4 dwg, 7 ex Изобретение относится к области биотехнологии, биологии и медицины. Предложена клеточная линия huFSHIK - продуцент рекомбинантного человеческого фолликулостимулирующего гормона (ФСГ), секретируемого в культуральную жидкость. В суспензионной культуре линия секретирует ФСГ в концентрации 18 МЕ/10клеток в день. Настоящее изобретение оптимизирует систему экспрессии ФСГ, что приводит к увеличению его продукции и повышению эффективности и экономичности производства ФСГ в медицинских целях. 4 ил., 7 пр.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
title CELL LINE HUFSHIK RELEASING RECOMBINANT HUMAN FOLLICLE-STIMULATING HORMONE
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