INTERLEUKIN-13 BINDING PROTEINS
FIELD: chemistry.SUBSTANCE: disclosed is a binding protein which is specific to IL-13, having 6CDR sections (three light and three heavy chains). The invention discloses a structure of an antibody based on this protein and a conjugate based on the antibody. The invention describes versions of nuclei...
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| creator | MELIM TERRI L BELK DZHONATAN P KHINTON POL R CHEHN' JAN' IN KHUA KAFF KEHROLIN A KUMAR SHANKAR ARDZHIRIADI MARIJA A DIKSON RICHARD V VU CHENBIN |
| description | FIELD: chemistry.SUBSTANCE: disclosed is a binding protein which is specific to IL-13, having 6CDR sections (three light and three heavy chains). The invention discloses a structure of an antibody based on this protein and a conjugate based on the antibody. The invention describes versions of nucleic acid which codes the antibody or structure, and an expression vector, a replication vector and cells bearing such vectors. Described is a method of producing the protein by culturing cells and proteins obtained using said method. Described are compositions based on versions of the proteins.EFFECT: invention can be used in medicine to treat and diagnose diseases associated with IL-13 activity which negatively affects health.50 cl, 23 tbl, 2 ex
Настоящее изобретение относится к области иммунологии. Предложен связывающий белок, специфичный к IL-13, содержащий 6CDR участков (три из легкой и три из тяжелой цепи). Раскрыты конструкция антитела на основе этого белка и конъюгат на основе антитела. Описаны: варианты НК, кодирующей антитело или конструкцию, а также вектор экспрессии, вектор репликации и клетки, несущие такие вектора. Описан способ получения белка путем культивирования клетки и белок, полученный указанным способом. Описаны композиции на основе вариантов белков. Использование изобретения может найти применение в медицине в лечении и диагностике заболеваний, связанных активностью IL-13, негативно влияющей на здоровье. 13 н. и 37 з.п. ф-лы, 23 табл., 2 пр. |
| format | Patent |
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Настоящее изобретение относится к области иммунологии. Предложен связывающий белок, специфичный к IL-13, содержащий 6CDR участков (три из легкой и три из тяжелой цепи). Раскрыты конструкция антитела на основе этого белка и конъюгат на основе антитела. Описаны: варианты НК, кодирующей антитело или конструкцию, а также вектор экспрессии, вектор репликации и клетки, несущие такие вектора. Описан способ получения белка путем культивирования клетки и белок, полученный указанным способом. Описаны композиции на основе вариантов белков. Использование изобретения может найти применение в медицине в лечении и диагностике заболеваний, связанных активностью IL-13, негативно влияющей на здоровье. 13 н. и 37 з.п. ф-лы, 23 табл., 2 пр.</description><language>eng ; rus</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130120&DB=EPODOC&CC=RU&NR=2472807C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130120&DB=EPODOC&CC=RU&NR=2472807C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MELIM TERRI L</creatorcontrib><creatorcontrib>BELK DZHONATAN P</creatorcontrib><creatorcontrib>KHINTON POL R</creatorcontrib><creatorcontrib>CHEHN' JAN'</creatorcontrib><creatorcontrib>IN KHUA</creatorcontrib><creatorcontrib>KAFF KEHROLIN A</creatorcontrib><creatorcontrib>KUMAR SHANKAR</creatorcontrib><creatorcontrib>ARDZHIRIADI MARIJA A</creatorcontrib><creatorcontrib>DIKSON RICHARD V</creatorcontrib><creatorcontrib>VU CHENBIN</creatorcontrib><title>INTERLEUKIN-13 BINDING PROTEINS</title><description>FIELD: chemistry.SUBSTANCE: disclosed is a binding protein which is specific to IL-13, having 6CDR sections (three light and three heavy chains). The invention discloses a structure of an antibody based on this protein and a conjugate based on the antibody. The invention describes versions of nucleic acid which codes the antibody or structure, and an expression vector, a replication vector and cells bearing such vectors. Described is a method of producing the protein by culturing cells and proteins obtained using said method. Described are compositions based on versions of the proteins.EFFECT: invention can be used in medicine to treat and diagnose diseases associated with IL-13 activity which negatively affects health.50 cl, 23 tbl, 2 ex
Настоящее изобретение относится к области иммунологии. Предложен связывающий белок, специфичный к IL-13, содержащий 6CDR участков (три из легкой и три из тяжелой цепи). Раскрыты конструкция антитела на основе этого белка и конъюгат на основе антитела. Описаны: варианты НК, кодирующей антитело или конструкцию, а также вектор экспрессии, вектор репликации и клетки, несущие такие вектора. Описан способ получения белка путем культивирования клетки и белок, полученный указанным способом. Описаны композиции на основе вариантов белков. Использование изобретения может найти применение в медицине в лечении и диагностике заболеваний, связанных активностью IL-13, негативно влияющей на здоровье. 13 н. и 37 з.п. ф-лы, 23 табл., 2 пр.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJD39AtxDfJxDfX29NM1NFZw8vRz8fRzVwgI8g9x9fQL5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8UGhRibmRhYG5s5GxkQoAQCUXSFe</recordid><startdate>20130120</startdate><enddate>20130120</enddate><creator>MELIM TERRI L</creator><creator>BELK DZHONATAN P</creator><creator>KHINTON POL R</creator><creator>CHEHN' JAN'</creator><creator>IN KHUA</creator><creator>KAFF KEHROLIN A</creator><creator>KUMAR SHANKAR</creator><creator>ARDZHIRIADI MARIJA A</creator><creator>DIKSON RICHARD V</creator><creator>VU CHENBIN</creator><scope>EVB</scope></search><sort><creationdate>20130120</creationdate><title>INTERLEUKIN-13 BINDING PROTEINS</title><author>MELIM TERRI L ; BELK DZHONATAN P ; KHINTON POL R ; CHEHN' JAN' ; IN KHUA ; KAFF KEHROLIN A ; KUMAR SHANKAR ; ARDZHIRIADI MARIJA A ; DIKSON RICHARD V ; VU CHENBIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2472807C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2013</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MELIM TERRI L</creatorcontrib><creatorcontrib>BELK DZHONATAN P</creatorcontrib><creatorcontrib>KHINTON POL R</creatorcontrib><creatorcontrib>CHEHN' JAN'</creatorcontrib><creatorcontrib>IN KHUA</creatorcontrib><creatorcontrib>KAFF KEHROLIN A</creatorcontrib><creatorcontrib>KUMAR SHANKAR</creatorcontrib><creatorcontrib>ARDZHIRIADI MARIJA A</creatorcontrib><creatorcontrib>DIKSON RICHARD V</creatorcontrib><creatorcontrib>VU CHENBIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MELIM TERRI L</au><au>BELK DZHONATAN P</au><au>KHINTON POL R</au><au>CHEHN' JAN'</au><au>IN KHUA</au><au>KAFF KEHROLIN A</au><au>KUMAR SHANKAR</au><au>ARDZHIRIADI MARIJA A</au><au>DIKSON RICHARD V</au><au>VU CHENBIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INTERLEUKIN-13 BINDING PROTEINS</title><date>2013-01-20</date><risdate>2013</risdate><abstract>FIELD: chemistry.SUBSTANCE: disclosed is a binding protein which is specific to IL-13, having 6CDR sections (three light and three heavy chains). The invention discloses a structure of an antibody based on this protein and a conjugate based on the antibody. The invention describes versions of nucleic acid which codes the antibody or structure, and an expression vector, a replication vector and cells bearing such vectors. Described is a method of producing the protein by culturing cells and proteins obtained using said method. Described are compositions based on versions of the proteins.EFFECT: invention can be used in medicine to treat and diagnose diseases associated with IL-13 activity which negatively affects health.50 cl, 23 tbl, 2 ex
Настоящее изобретение относится к области иммунологии. Предложен связывающий белок, специфичный к IL-13, содержащий 6CDR участков (три из легкой и три из тяжелой цепи). Раскрыты конструкция антитела на основе этого белка и конъюгат на основе антитела. Описаны: варианты НК, кодирующей антитело или конструкцию, а также вектор экспрессии, вектор репликации и клетки, несущие такие вектора. Описан способ получения белка путем культивирования клетки и белок, полученный указанным способом. Описаны композиции на основе вариантов белков. Использование изобретения может найти применение в медицине в лечении и диагностике заболеваний, связанных активностью IL-13, негативно влияющей на здоровье. 13 н. и 37 з.п. ф-лы, 23 табл., 2 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | INTERLEUKIN-13 BINDING PROTEINS |
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