NUCLEIC ACID CODING FUNCTIONALLY ACTIVE RECOMBINANT IgAL PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, RECOMBINANT PLASMID DNA CONTAINING NUCLEOTIDE SEQUENCE CODING ACTIVE IgAL PROTEASE, PRODUCER STRAIN CONTAINING PLASMID DNA PRODUCING MATURE FORM OF IgAL PROTEASE, RECOMBINANT Ig PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, METHOD FOR PRODUCING MATURE FORM IgAL PROTEASE SHOWING IMMUNOGENIC AND PROTECTIVE PROPERTIES
FIELD: medicine. ^ SUBSTANCE: what is described is nucleic acid coding IgAl protease Neisseria meningitidis of serogroup B, strain H44/76. What is presented is recombinant plasmid DNA containing nucleic acid. What is described is producer strain E.coli BL21 (DE3)/pBIGAPSl containing presented recomb...
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| creator | SEROVA OKSANA VIKTOROVNA KOZLOV LEONID VASIL'EVICH RUMSH LEV DAVYDOVICH MEL'NIKOV EHDVARD EHDUARDOVICH ANOKHINA IRINA VIKTOROVNA ZHIGIS LARISA STEFANOVNA JAGUDAEVA ELENA JUR'EVNA ZUBOV VITALIJ PAVLOVICH AVAKOV ANATOLIJ EHDUARDOVICH ALLILUEV ALEKSANDR PAVLOVICH KOTEL'NIKOVA OL'GA VIKTOROVNA BICHUCHER ANNA MIRONOVNA ZUEVA VERA SERGEEVNA |
| description | FIELD: medicine. ^ SUBSTANCE: what is described is nucleic acid coding IgAl protease Neisseria meningitidis of serogroup B, strain H44/76. What is presented is recombinant plasmid DNA containing nucleic acid. What is described is producer strain E.coli BL21 (DE3)/pBIGAPSl containing presented recombinant plasmid DNA. What is presented is a method for producing a mature form of IgAl protease Neisseria meningitidis of serogroup B. What is described is IgAl protease of molecular weight 107.6 kDa and estimated calculated isoelectric point 7.4. ^ EFFECT: invention allows producing high-purity IgAl protease as an ingredient of a polyvalent vaccine intended for protection of an individual, at first of children, against meningococcal infection and other microorganisms pathogenicity of which is caused by IgAl protease. ^ 5 cl, 4 dwg, 5 ex
Изобретение относится к области иммунологии, энзимологии, микробиологии и генной инженерии. Описана нуклеиновая кислота, кодирующая IgA1 протеазу Neisseria meningitidis серогруппы В штамм Н44/76. Представлена рекомбинантная плазмидная ДНК, включающая нуклеиновую кислоту. Описан штамм-продуцент E.coli BL21(DE3)/pBIGAPS1, содержащий представленную рекомбинантную плазмидную ДНК. Представлен способ получения зрелой формы IgA1 протеазы Neisseria meningitidis серогруппы В. Описана IgA1 протеаза с молекулярной массой 107,6 кДа и рассчитанной изоэлектрической точкой 7,4. Изобретение позволяет получить высокоочищенную IgA1 протеазу в качестве компонента поливалентной вакцины, предназначенной для защиты человека, прежде всего детей от менингококковой инфекции и других микроорганизмов, патогенность которых обусловлена IgA1 протеазой. 5 н.п. ф-лы, 4 ил., 5 пр. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_RU2453599C1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>RU2453599C1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_RU2453599C13</originalsourceid><addsrcrecordid>eNqVUc1KAzEQrgcPRX2HeYB60NpDj2kyuzuwmVmTidJTKbJ6ES3Ud_I1TdwKXUGwpwyT7zeZnn1ysi2SBWPJgRVHXEOV2CoJm7Zd5wulB4SAVvyK2LACvZgWuiCKJiIwUowYyIBHznRSchRBKshbqYOkDlazkUDXmuizn2OTPVkNFSJ8Z5FMx0y9T8gWfyIdUoycZ2VyyWKAqCFrHGsdWwywsvVGU0CoJPgS8JfcuOPJDT1qI66I_-E4frfYyGNBkPeJpc7K-RfYDYChbh47DEoYLyfnz9vXfX91OC8mUKHa5rrfvW_6_W771L_1H5uQbu8W88VyaW_m_4B8AYz1jNQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NUCLEIC ACID CODING FUNCTIONALLY ACTIVE RECOMBINANT IgAL PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, RECOMBINANT PLASMID DNA CONTAINING NUCLEOTIDE SEQUENCE CODING ACTIVE IgAL PROTEASE, PRODUCER STRAIN CONTAINING PLASMID DNA PRODUCING MATURE FORM OF IgAL PROTEASE, RECOMBINANT Ig PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, METHOD FOR PRODUCING MATURE FORM IgAL PROTEASE SHOWING IMMUNOGENIC AND PROTECTIVE PROPERTIES</title><source>esp@cenet</source><creator>SEROVA OKSANA VIKTOROVNA ; KOZLOV LEONID VASIL'EVICH ; RUMSH LEV DAVYDOVICH ; MEL'NIKOV EHDVARD EHDUARDOVICH ; ANOKHINA IRINA VIKTOROVNA ; ZHIGIS LARISA STEFANOVNA ; JAGUDAEVA ELENA JUR'EVNA ; ZUBOV VITALIJ PAVLOVICH ; AVAKOV ANATOLIJ EHDUARDOVICH ; ALLILUEV ALEKSANDR PAVLOVICH ; KOTEL'NIKOVA OL'GA VIKTOROVNA ; BICHUCHER ANNA MIRONOVNA ; ZUEVA VERA SERGEEVNA</creator><creatorcontrib>SEROVA OKSANA VIKTOROVNA ; KOZLOV LEONID VASIL'EVICH ; RUMSH LEV DAVYDOVICH ; MEL'NIKOV EHDVARD EHDUARDOVICH ; ANOKHINA IRINA VIKTOROVNA ; ZHIGIS LARISA STEFANOVNA ; JAGUDAEVA ELENA JUR'EVNA ; ZUBOV VITALIJ PAVLOVICH ; AVAKOV ANATOLIJ EHDUARDOVICH ; ALLILUEV ALEKSANDR PAVLOVICH ; KOTEL'NIKOVA OL'GA VIKTOROVNA ; BICHUCHER ANNA MIRONOVNA ; ZUEVA VERA SERGEEVNA</creatorcontrib><description>FIELD: medicine. ^ SUBSTANCE: what is described is nucleic acid coding IgAl protease Neisseria meningitidis of serogroup B, strain H44/76. What is presented is recombinant plasmid DNA containing nucleic acid. What is described is producer strain E.coli BL21 (DE3)/pBIGAPSl containing presented recombinant plasmid DNA. What is presented is a method for producing a mature form of IgAl protease Neisseria meningitidis of serogroup B. What is described is IgAl protease of molecular weight 107.6 kDa and estimated calculated isoelectric point 7.4. ^ EFFECT: invention allows producing high-purity IgAl protease as an ingredient of a polyvalent vaccine intended for protection of an individual, at first of children, against meningococcal infection and other microorganisms pathogenicity of which is caused by IgAl protease. ^ 5 cl, 4 dwg, 5 ex
Изобретение относится к области иммунологии, энзимологии, микробиологии и генной инженерии. Описана нуклеиновая кислота, кодирующая IgA1 протеазу Neisseria meningitidis серогруппы В штамм Н44/76. Представлена рекомбинантная плазмидная ДНК, включающая нуклеиновую кислоту. Описан штамм-продуцент E.coli BL21(DE3)/pBIGAPS1, содержащий представленную рекомбинантную плазмидную ДНК. Представлен способ получения зрелой формы IgA1 протеазы Neisseria meningitidis серогруппы В. Описана IgA1 протеаза с молекулярной массой 107,6 кДа и рассчитанной изоэлектрической точкой 7,4. Изобретение позволяет получить высокоочищенную IgA1 протеазу в качестве компонента поливалентной вакцины, предназначенной для защиты человека, прежде всего детей от менингококковой инфекции и других микроорганизмов, патогенность которых обусловлена IgA1 протеазой. 5 н.п. ф-лы, 4 ил., 5 пр.</description><language>eng ; rus</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120620&DB=EPODOC&CC=RU&NR=2453599C1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120620&DB=EPODOC&CC=RU&NR=2453599C1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SEROVA OKSANA VIKTOROVNA</creatorcontrib><creatorcontrib>KOZLOV LEONID VASIL'EVICH</creatorcontrib><creatorcontrib>RUMSH LEV DAVYDOVICH</creatorcontrib><creatorcontrib>MEL'NIKOV EHDVARD EHDUARDOVICH</creatorcontrib><creatorcontrib>ANOKHINA IRINA VIKTOROVNA</creatorcontrib><creatorcontrib>ZHIGIS LARISA STEFANOVNA</creatorcontrib><creatorcontrib>JAGUDAEVA ELENA JUR'EVNA</creatorcontrib><creatorcontrib>ZUBOV VITALIJ PAVLOVICH</creatorcontrib><creatorcontrib>AVAKOV ANATOLIJ EHDUARDOVICH</creatorcontrib><creatorcontrib>ALLILUEV ALEKSANDR PAVLOVICH</creatorcontrib><creatorcontrib>KOTEL'NIKOVA OL'GA VIKTOROVNA</creatorcontrib><creatorcontrib>BICHUCHER ANNA MIRONOVNA</creatorcontrib><creatorcontrib>ZUEVA VERA SERGEEVNA</creatorcontrib><title>NUCLEIC ACID CODING FUNCTIONALLY ACTIVE RECOMBINANT IgAL PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, RECOMBINANT PLASMID DNA CONTAINING NUCLEOTIDE SEQUENCE CODING ACTIVE IgAL PROTEASE, PRODUCER STRAIN CONTAINING PLASMID DNA PRODUCING MATURE FORM OF IgAL PROTEASE, RECOMBINANT Ig PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, METHOD FOR PRODUCING MATURE FORM IgAL PROTEASE SHOWING IMMUNOGENIC AND PROTECTIVE PROPERTIES</title><description>FIELD: medicine. ^ SUBSTANCE: what is described is nucleic acid coding IgAl protease Neisseria meningitidis of serogroup B, strain H44/76. What is presented is recombinant plasmid DNA containing nucleic acid. What is described is producer strain E.coli BL21 (DE3)/pBIGAPSl containing presented recombinant plasmid DNA. What is presented is a method for producing a mature form of IgAl protease Neisseria meningitidis of serogroup B. What is described is IgAl protease of molecular weight 107.6 kDa and estimated calculated isoelectric point 7.4. ^ EFFECT: invention allows producing high-purity IgAl protease as an ingredient of a polyvalent vaccine intended for protection of an individual, at first of children, against meningococcal infection and other microorganisms pathogenicity of which is caused by IgAl protease. ^ 5 cl, 4 dwg, 5 ex
Изобретение относится к области иммунологии, энзимологии, микробиологии и генной инженерии. Описана нуклеиновая кислота, кодирующая IgA1 протеазу Neisseria meningitidis серогруппы В штамм Н44/76. Представлена рекомбинантная плазмидная ДНК, включающая нуклеиновую кислоту. Описан штамм-продуцент E.coli BL21(DE3)/pBIGAPS1, содержащий представленную рекомбинантную плазмидную ДНК. Представлен способ получения зрелой формы IgA1 протеазы Neisseria meningitidis серогруппы В. Описана IgA1 протеаза с молекулярной массой 107,6 кДа и рассчитанной изоэлектрической точкой 7,4. Изобретение позволяет получить высокоочищенную IgA1 протеазу в качестве компонента поливалентной вакцины, предназначенной для защиты человека, прежде всего детей от менингококковой инфекции и других микроорганизмов, патогенность которых обусловлена IgA1 протеазой. 5 н.п. ф-лы, 4 ил., 5 пр.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqVUc1KAzEQrgcPRX2HeYB60NpDj2kyuzuwmVmTidJTKbJ6ES3Ud_I1TdwKXUGwpwyT7zeZnn1ysi2SBWPJgRVHXEOV2CoJm7Zd5wulB4SAVvyK2LACvZgWuiCKJiIwUowYyIBHznRSchRBKshbqYOkDlazkUDXmuizn2OTPVkNFSJ8Z5FMx0y9T8gWfyIdUoycZ2VyyWKAqCFrHGsdWwywsvVGU0CoJPgS8JfcuOPJDT1qI66I_-E4frfYyGNBkPeJpc7K-RfYDYChbh47DEoYLyfnz9vXfX91OC8mUKHa5rrfvW_6_W771L_1H5uQbu8W88VyaW_m_4B8AYz1jNQ</recordid><startdate>20120620</startdate><enddate>20120620</enddate><creator>SEROVA OKSANA VIKTOROVNA</creator><creator>KOZLOV LEONID VASIL'EVICH</creator><creator>RUMSH LEV DAVYDOVICH</creator><creator>MEL'NIKOV EHDVARD EHDUARDOVICH</creator><creator>ANOKHINA IRINA VIKTOROVNA</creator><creator>ZHIGIS LARISA STEFANOVNA</creator><creator>JAGUDAEVA ELENA JUR'EVNA</creator><creator>ZUBOV VITALIJ PAVLOVICH</creator><creator>AVAKOV ANATOLIJ EHDUARDOVICH</creator><creator>ALLILUEV ALEKSANDR PAVLOVICH</creator><creator>KOTEL'NIKOVA OL'GA VIKTOROVNA</creator><creator>BICHUCHER ANNA MIRONOVNA</creator><creator>ZUEVA VERA SERGEEVNA</creator><scope>EVB</scope></search><sort><creationdate>20120620</creationdate><title>NUCLEIC ACID CODING FUNCTIONALLY ACTIVE RECOMBINANT IgAL PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, RECOMBINANT PLASMID DNA CONTAINING NUCLEOTIDE SEQUENCE CODING ACTIVE IgAL PROTEASE, PRODUCER STRAIN CONTAINING PLASMID DNA PRODUCING MATURE FORM OF IgAL PROTEASE, RECOMBINANT Ig PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, METHOD FOR PRODUCING MATURE FORM IgAL PROTEASE SHOWING IMMUNOGENIC AND PROTECTIVE PROPERTIES</title><author>SEROVA OKSANA VIKTOROVNA ; KOZLOV LEONID VASIL'EVICH ; RUMSH LEV DAVYDOVICH ; MEL'NIKOV EHDVARD EHDUARDOVICH ; ANOKHINA IRINA VIKTOROVNA ; ZHIGIS LARISA STEFANOVNA ; JAGUDAEVA ELENA JUR'EVNA ; ZUBOV VITALIJ PAVLOVICH ; AVAKOV ANATOLIJ EHDUARDOVICH ; ALLILUEV ALEKSANDR PAVLOVICH ; KOTEL'NIKOVA OL'GA VIKTOROVNA ; BICHUCHER ANNA MIRONOVNA ; ZUEVA VERA SERGEEVNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2453599C13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2012</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SEROVA OKSANA VIKTOROVNA</creatorcontrib><creatorcontrib>KOZLOV LEONID VASIL'EVICH</creatorcontrib><creatorcontrib>RUMSH LEV DAVYDOVICH</creatorcontrib><creatorcontrib>MEL'NIKOV EHDVARD EHDUARDOVICH</creatorcontrib><creatorcontrib>ANOKHINA IRINA VIKTOROVNA</creatorcontrib><creatorcontrib>ZHIGIS LARISA STEFANOVNA</creatorcontrib><creatorcontrib>JAGUDAEVA ELENA JUR'EVNA</creatorcontrib><creatorcontrib>ZUBOV VITALIJ PAVLOVICH</creatorcontrib><creatorcontrib>AVAKOV ANATOLIJ EHDUARDOVICH</creatorcontrib><creatorcontrib>ALLILUEV ALEKSANDR PAVLOVICH</creatorcontrib><creatorcontrib>KOTEL'NIKOVA OL'GA VIKTOROVNA</creatorcontrib><creatorcontrib>BICHUCHER ANNA MIRONOVNA</creatorcontrib><creatorcontrib>ZUEVA VERA SERGEEVNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SEROVA OKSANA VIKTOROVNA</au><au>KOZLOV LEONID VASIL'EVICH</au><au>RUMSH LEV DAVYDOVICH</au><au>MEL'NIKOV EHDVARD EHDUARDOVICH</au><au>ANOKHINA IRINA VIKTOROVNA</au><au>ZHIGIS LARISA STEFANOVNA</au><au>JAGUDAEVA ELENA JUR'EVNA</au><au>ZUBOV VITALIJ PAVLOVICH</au><au>AVAKOV ANATOLIJ EHDUARDOVICH</au><au>ALLILUEV ALEKSANDR PAVLOVICH</au><au>KOTEL'NIKOVA OL'GA VIKTOROVNA</au><au>BICHUCHER ANNA MIRONOVNA</au><au>ZUEVA VERA SERGEEVNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NUCLEIC ACID CODING FUNCTIONALLY ACTIVE RECOMBINANT IgAL PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, RECOMBINANT PLASMID DNA CONTAINING NUCLEOTIDE SEQUENCE CODING ACTIVE IgAL PROTEASE, PRODUCER STRAIN CONTAINING PLASMID DNA PRODUCING MATURE FORM OF IgAL PROTEASE, RECOMBINANT Ig PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, METHOD FOR PRODUCING MATURE FORM IgAL PROTEASE SHOWING IMMUNOGENIC AND PROTECTIVE PROPERTIES</title><date>2012-06-20</date><risdate>2012</risdate><abstract>FIELD: medicine. ^ SUBSTANCE: what is described is nucleic acid coding IgAl protease Neisseria meningitidis of serogroup B, strain H44/76. What is presented is recombinant plasmid DNA containing nucleic acid. What is described is producer strain E.coli BL21 (DE3)/pBIGAPSl containing presented recombinant plasmid DNA. What is presented is a method for producing a mature form of IgAl protease Neisseria meningitidis of serogroup B. What is described is IgAl protease of molecular weight 107.6 kDa and estimated calculated isoelectric point 7.4. ^ EFFECT: invention allows producing high-purity IgAl protease as an ingredient of a polyvalent vaccine intended for protection of an individual, at first of children, against meningococcal infection and other microorganisms pathogenicity of which is caused by IgAl protease. ^ 5 cl, 4 dwg, 5 ex
Изобретение относится к области иммунологии, энзимологии, микробиологии и генной инженерии. Описана нуклеиновая кислота, кодирующая IgA1 протеазу Neisseria meningitidis серогруппы В штамм Н44/76. Представлена рекомбинантная плазмидная ДНК, включающая нуклеиновую кислоту. Описан штамм-продуцент E.coli BL21(DE3)/pBIGAPS1, содержащий представленную рекомбинантную плазмидную ДНК. Представлен способ получения зрелой формы IgA1 протеазы Neisseria meningitidis серогруппы В. Описана IgA1 протеаза с молекулярной массой 107,6 кДа и рассчитанной изоэлектрической точкой 7,4. Изобретение позволяет получить высокоочищенную IgA1 протеазу в качестве компонента поливалентной вакцины, предназначенной для защиты человека, прежде всего детей от менингококковой инфекции и других микроорганизмов, патогенность которых обусловлена IgA1 протеазой. 5 н.п. ф-лы, 4 ил., 5 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | NUCLEIC ACID CODING FUNCTIONALLY ACTIVE RECOMBINANT IgAL PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, RECOMBINANT PLASMID DNA CONTAINING NUCLEOTIDE SEQUENCE CODING ACTIVE IgAL PROTEASE, PRODUCER STRAIN CONTAINING PLASMID DNA PRODUCING MATURE FORM OF IgAL PROTEASE, RECOMBINANT Ig PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, METHOD FOR PRODUCING MATURE FORM IgAL PROTEASE SHOWING IMMUNOGENIC AND PROTECTIVE PROPERTIES |
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