SUBSTITUTED IMIDAZOLES, PHARMACEUTICAL COMPOSITION, METHOD OF TREATING DISEASE, ASSOCIATED WITH, AT LEAST, KSP ACTIVITY AND METHOD OF KSP INHIBITION
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: claimed invention relates to novel substituted imidazole compounds of formula I where values of radicals are given in description, as well as to their based on them pharmaceutical compositions. ^ EFFECT: formula I compounds, as well as their salts, esters...
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| creator | RENKHOUV PAUL A REHMERTI SAVITRI SIA JI VANG VEJBO BOJS RASTAM KONSTANTAJN RAJAN DAL DEHVID UOLTER ANETT O BRAMMEJER NATAN M SUBRAMANIAN SHARADKHA BARSANTI PAUL A ABRAMS TINIA DZH MENDENKHEHLL KRIS G LAGNITON LIANA M FILLIPS MEGAN K |
| description | FIELD: medicine, pharmaceutics. ^ SUBSTANCE: claimed invention relates to novel substituted imidazole compounds of formula I where values of radicals are given in description, as well as to their based on them pharmaceutical compositions. ^ EFFECT: formula I compounds, as well as their salts, esters and compositions based on them possess ability to inhibit protein of kinesin spindle (KSP) and can be used for treatment of cancer diseases. ^ 40 cl, 15 ex, 3 tbl
Настоящее изобретение относится к новым замещенным соединениям имидазола формулы I ! ! где значения радикалов раскрыты в описании, а также к их фармацевтически приемлемым солям и сложным эфирам и к фармацевтическим композициям на их основе. Было обнаружено, что соединения формулы I, а также их соли, эфиры и композиции на их основе обладают способностью ингибировать белок веретена кинезина (KSP) и могут быть использованы для лечения раковых заболеваний. 4 н. и 36 з.п. ф-лы, 3 табл. |
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Настоящее изобретение относится к новым замещенным соединениям имидазола формулы I ! ! где значения радикалов раскрыты в описании, а также к их фармацевтически приемлемым солям и сложным эфирам и к фармацевтическим композициям на их основе. Было обнаружено, что соединения формулы I, а также их соли, эфиры и композиции на их основе обладают способностью ингибировать белок веретена кинезина (KSP) и могут быть использованы для лечения раковых заболеваний. 4 н. и 36 з.п. ф-лы, 3 табл.</description><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110520&DB=EPODOC&CC=RU&NR=2413721C9$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110520&DB=EPODOC&CC=RU&NR=2413721C9$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RENKHOUV PAUL A</creatorcontrib><creatorcontrib>REHMERTI SAVITRI</creatorcontrib><creatorcontrib>SIA JI</creatorcontrib><creatorcontrib>VANG VEJBO</creatorcontrib><creatorcontrib>BOJS RASTAM</creatorcontrib><creatorcontrib>KONSTANTAJN RAJAN</creatorcontrib><creatorcontrib>DAL DEHVID</creatorcontrib><creatorcontrib>UOLTER ANETT O</creatorcontrib><creatorcontrib>BRAMMEJER NATAN M</creatorcontrib><creatorcontrib>SUBRAMANIAN SHARADKHA</creatorcontrib><creatorcontrib>BARSANTI PAUL A</creatorcontrib><creatorcontrib>ABRAMS TINIA DZH</creatorcontrib><creatorcontrib>MENDENKHEHLL KRIS G</creatorcontrib><creatorcontrib>LAGNITON LIANA M</creatorcontrib><creatorcontrib>FILLIPS MEGAN K</creatorcontrib><title>SUBSTITUTED IMIDAZOLES, PHARMACEUTICAL COMPOSITION, METHOD OF TREATING DISEASE, ASSOCIATED WITH, AT LEAST, KSP ACTIVITY AND METHOD OF KSP INHIBITION</title><description>FIELD: medicine, pharmaceutics. ^ SUBSTANCE: claimed invention relates to novel substituted imidazole compounds of formula I where values of radicals are given in description, as well as to their based on them pharmaceutical compositions. ^ EFFECT: formula I compounds, as well as their salts, esters and compositions based on them possess ability to inhibit protein of kinesin spindle (KSP) and can be used for treatment of cancer diseases. ^ 40 cl, 15 ex, 3 tbl
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| title | SUBSTITUTED IMIDAZOLES, PHARMACEUTICAL COMPOSITION, METHOD OF TREATING DISEASE, ASSOCIATED WITH, AT LEAST, KSP ACTIVITY AND METHOD OF KSP INHIBITION |
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