SUBSTITUTED IMIDAZOLES, PHARMACEUTICAL COMPOSITION, METHOD OF TREATING DISEASE, ASSOCIATED WITH, AT LEAST, KSP ACTIVITY AND METHOD OF KSP INHIBITION

SUBSTITUTED IMIDAZOLES, PHARMACEUTICAL COMPOSITION, METHOD OF TREATING DISEASE, ASSOCIATED WITH, AT LEAST, KSP ACTIVITY AND METHOD OF KSP INHIBITION

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: claimed invention relates to novel substituted imidazole compounds of formula I where values of radicals are given in description, as well as to their based on them pharmaceutical compositions. ^ EFFECT: formula I compounds, as well as their salts, esters...

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Hauptverfasser: RENKHOUV PAUL A, REHMERTI SAVITRI, SIA JI, VANG VEJBO, BOJS RASTAM, KONSTANTAJN RAJAN, DAL DEHVID, UOLTER ANETT O, BRAMMEJER NATAN M, SUBRAMANIAN SHARADKHA, BARSANTI PAUL A, ABRAMS TINIA DZH, MENDENKHEHLL KRIS G, LAGNITON LIANA M, FILLIPS MEGAN K
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: medicine, pharmaceutics. ^ SUBSTANCE: claimed invention relates to novel substituted imidazole compounds of formula I where values of radicals are given in description, as well as to their based on them pharmaceutical compositions. ^ EFFECT: formula I compounds, as well as their salts, esters and compositions based on them possess ability to inhibit protein of kinesin spindle (KSP) and can be used for treatment of cancer diseases. ^ 40 cl, 15 ex, 3 tbl Настоящее изобретение относится к новым замещенным соединениям имидазола формулы I ! ! где значения радикалов раскрыты в описании, а также к их фармацевтически приемлемым солям и сложным эфирам и к фармацевтическим композициям на их основе. Было обнаружено, что соединения формулы I, а также их соли, эфиры и композиции на их основе обладают способностью ингибировать белок веретена кинезина (KSP) и могут быть использованы для лечения раковых заболеваний. 4 н. и 36 з.п. ф-лы, 3 табл.