METHOD OF PREDICTING OUTCOME OF PRE-OPERATIONAL RADIOTHERAPY OF SQUAMOUS CELL CARCINOMAS OF HEAD AND NECK
FIELD: medicine. ^ SUBSTANCE: invention relates to field of medicine, in particular to oncology and radiotherapy. ELISA analysis of blood serum sampled before treatment, during which levels of content of tissue inhibitors of matrix metalloproteinases TIMP-1 and TIMP-2 is carried out, and if TIMP-1 l...
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| creator | KLISHO ELENA VLADIMIROVNA MUKHAMEDOV MARAT RAFKATOVICH SHISHKIN DMITRIJ ALEKSANDROVICH CHOJNZONOV EVGENIJ LKHAMATSYRENOVICH KONDAKOVA IRINA VIKTOROVNA |
| description | FIELD: medicine. ^ SUBSTANCE: invention relates to field of medicine, in particular to oncology and radiotherapy. ELISA analysis of blood serum sampled before treatment, during which levels of content of tissue inhibitors of matrix metalloproteinases TIMP-1 and TIMP-2 is carried out, and if TIMP-1 level is lower than 133.5 ng/ml and TIMP-2 level is lower than 88.4 ng/ml, radiotherapy is estimated as efficient, if TIMP-1 level is higher than 193.2 ng/ml and TIMP-2 level is higher than 125.9 ng/ml - absence of response to radiotherapy of squamous cell carcinomas of head and neck. ^ EFFECT: method ensures increase of efficiency of treatment of patients with malignant neoplasms of head and neck. ^ 2 ex
Изобретение относится к области медицины, в частности к онкологии и лучевой терапии. Способ обеспечивает повышение эффективности лечения больных злокачественными новообразованиями головы и шеи. Проводят иммуноферментное исследование сыворотки крови, забранной до начала лечения, при котором определяют уровни содержания тканевых ингибиторов матриксных металлопротеиназ ТИМП-1 и ТИМП-2, и при уровне ТИМП-1 менее 133,5 нг/мл и уровне ТИМП-2 - менее 88,4 нг/л оценивают лучевую терапию как эффективную, а при уровне ТИМП-1 более 193,2 нг/мл и уровне ТИМП-2 более 125,9 нг/мл - отсутствие ответа на лучевую терапию плоскоклеточных карцином головы и шеи. |
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Изобретение относится к области медицины, в частности к онкологии и лучевой терапии. Способ обеспечивает повышение эффективности лечения больных злокачественными новообразованиями головы и шеи. Проводят иммуноферментное исследование сыворотки крови, забранной до начала лечения, при котором определяют уровни содержания тканевых ингибиторов матриксных металлопротеиназ ТИМП-1 и ТИМП-2, и при уровне ТИМП-1 менее 133,5 нг/мл и уровне ТИМП-2 - менее 88,4 нг/л оценивают лучевую терапию как эффективную, а при уровне ТИМП-1 более 193,2 нг/мл и уровне ТИМП-2 более 125,9 нг/мл - отсутствие ответа на лучевую терапию плоскоклеточных карцином головы и шеи.</description><language>eng ; rus</language><subject>DIAGNOSIS ; HUMAN NECESSITIES ; HYGIENE ; IDENTIFICATION ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; PHYSICS ; SURGERY ; TESTING</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110110&DB=EPODOC&CC=RU&NR=2408284C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110110&DB=EPODOC&CC=RU&NR=2408284C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KLISHO ELENA VLADIMIROVNA</creatorcontrib><creatorcontrib>MUKHAMEDOV MARAT RAFKATOVICH</creatorcontrib><creatorcontrib>SHISHKIN DMITRIJ ALEKSANDROVICH</creatorcontrib><creatorcontrib>CHOJNZONOV EVGENIJ LKHAMATSYRENOVICH</creatorcontrib><creatorcontrib>KONDAKOVA IRINA VIKTOROVNA</creatorcontrib><title>METHOD OF PREDICTING OUTCOME OF PRE-OPERATIONAL RADIOTHERAPY OF SQUAMOUS CELL CARCINOMAS OF HEAD AND NECK</title><description>FIELD: medicine. ^ SUBSTANCE: invention relates to field of medicine, in particular to oncology and radiotherapy. ELISA analysis of blood serum sampled before treatment, during which levels of content of tissue inhibitors of matrix metalloproteinases TIMP-1 and TIMP-2 is carried out, and if TIMP-1 level is lower than 133.5 ng/ml and TIMP-2 level is lower than 88.4 ng/ml, radiotherapy is estimated as efficient, if TIMP-1 level is higher than 193.2 ng/ml and TIMP-2 level is higher than 125.9 ng/ml - absence of response to radiotherapy of squamous cell carcinomas of head and neck. ^ EFFECT: method ensures increase of efficiency of treatment of patients with malignant neoplasms of head and neck. ^ 2 ex
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Изобретение относится к области медицины, в частности к онкологии и лучевой терапии. Способ обеспечивает повышение эффективности лечения больных злокачественными новообразованиями головы и шеи. Проводят иммуноферментное исследование сыворотки крови, забранной до начала лечения, при котором определяют уровни содержания тканевых ингибиторов матриксных металлопротеиназ ТИМП-1 и ТИМП-2, и при уровне ТИМП-1 менее 133,5 нг/мл и уровне ТИМП-2 - менее 88,4 нг/л оценивают лучевую терапию как эффективную, а при уровне ТИМП-1 более 193,2 нг/мл и уровне ТИМП-2 более 125,9 нг/мл - отсутствие ответа на лучевую терапию плоскоклеточных карцином головы и шеи.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | DIAGNOSIS HUMAN NECESSITIES HYGIENE IDENTIFICATION INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS SURGERY TESTING |
| title | METHOD OF PREDICTING OUTCOME OF PRE-OPERATIONAL RADIOTHERAPY OF SQUAMOUS CELL CARCINOMAS OF HEAD AND NECK |
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