VEGF BINDING V9 NANOANTIBODY AND METHOD OF OBTAINING SAID ANTIBODY, V9-CODING NUCLEOTIDE SEQUENCE AND VECTOR CONTAINING SAID SEQUENCE, ENDOTHELIAL CELL PROLIFERATION INHIBITION METHOD

FIELD: chemistry. ^ SUBSTANCE: invention relates to immunology and biotechnology. The invention describes a nucleotide sequence which codes the V9 nanoantibody and its expression vector with extra epitope(s) on the C-end for detection and extraction and a signal peptide on the N-end. The invention d...

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Hauptverfasser:	VJATCHANIN ANTON SERGEEVICH, KIBARDIN ALEKSEJ VLADIMIROVICH, LARIN SERGEJ SERGEEVICH, ZAKHAROVA ELENA SERGEEVNA, KOROBKO ELENA VLADIMIROVNA, KALINICHENKO SVETLANA VIKTOROVNA, IVANOVA TAT'JANA IL'INICHNA, TILLIB SERGEJ VLADIMIROVICH, GEORGIEV GEORGIJ PAVLOVICH, KOROBKO IGOR' VIKTOROVICH, GNUCHEV NIKOLAJ VASIL'EVICH, VIKHREVA POLINA NIKITICHNA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MANUFACTURE OR TREATMENT THEREOF MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS NANOTECHNOLOGY ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING TRANSPORTING VINEGAR WINE
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creator	VJATCHANIN ANTON SERGEEVICH KIBARDIN ALEKSEJ VLADIMIROVICH LARIN SERGEJ SERGEEVICH ZAKHAROVA ELENA SERGEEVNA KOROBKO ELENA VLADIMIROVNA KALINICHENKO SVETLANA VIKTOROVNA IVANOVA TAT'JANA IL'INICHNA TILLIB SERGEJ VLADIMIROVICH GEORGIEV GEORGIJ PAVLOVICH KOROBKO IGOR' VIKTOROVICH GNUCHEV NIKOLAJ VASIL'EVICH VIKHREVA POLINA NIKITICHNA
description	FIELD: chemistry. ^ SUBSTANCE: invention relates to immunology and biotechnology. The invention describes a nucleotide sequence which codes the V9 nanoantibody and its expression vector with extra epitope(s) on the C-end for detection and extraction and a signal peptide on the N-end. The invention discloses a method of obtaining the V9 nanoantibody, a method of inhibiting proliferation of endothelial cells using the V9 nanoantibody, as well as use of the V9 nanoantibody for qualitative and quantitative determination of VEGF in a sample. Use of the invention provides high-affinity neutralising monovalent single-strand nanoantibodies which are more resistant to external factors (temperature, pH) and cheaper to produce compared to conventional VEGF antibodies, which can be useful in medicine for treating and diagnosing diseases associated with regulation of the activity of the vascular endothelial growth factor (VEGF). ^ EFFECT: invention discloses a monomer single-strand V9 nanoantibody which can bind and inhibit the human vascular endothelial growth factor. ^ 7 cl, 7 dwg, 7 ex Изобретение относится к иммунологии и биотехнологии. Предложено мономерное одноцепочечное наноантитело V9, способное связывать фактор роста эндотелия сосудов человека и блокировать его действие. Описаны нуклеотидная последовательность, кодирующая наноантитело V9, и вектор для его экспрессии с дополнительным(и) эпитопом(ами) на С-конце для детекции и выделения и сигнальным пептидом на N-конце. Раскрыты: способ получения наноантитела V9, способ ингибирования пролиферации эндотелиальных клеток с помощью наноантитела V9, а также применение наноантитела V9 для качественного и количественного определения VEGF в образце. Использование изобретения обеспечивает высокоаффинные нейтрализующие моновалентные одноцепочечные наноантитела, более устойчивые к внешним факторам (температура, рН) и более дешевые в производстве по сравнению с классическими антителами к VEGF, что может найти применение в медицине для лечения и диагностики заболеваний, связанных с регуляцией активности фактора роста эндотелия сосудов (VEGF). 6 н. и 1 з.п. ф-лы, 7 ил.
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The invention describes a nucleotide sequence which codes the V9 nanoantibody and its expression vector with extra epitope(s) on the C-end for detection and extraction and a signal peptide on the N-end. The invention discloses a method of obtaining the V9 nanoantibody, a method of inhibiting proliferation of endothelial cells using the V9 nanoantibody, as well as use of the V9 nanoantibody for qualitative and quantitative determination of VEGF in a sample. Use of the invention provides high-affinity neutralising monovalent single-strand nanoantibodies which are more resistant to external factors (temperature, pH) and cheaper to produce compared to conventional VEGF antibodies, which can be useful in medicine for treating and diagnosing diseases associated with regulation of the activity of the vascular endothelial growth factor (VEGF). ^ EFFECT: invention discloses a monomer single-strand V9 nanoantibody which can bind and inhibit the human vascular endothelial growth factor. ^ 7 cl, 7 dwg, 7 ex Изобретение относится к иммунологии и биотехнологии. Предложено мономерное одноцепочечное наноантитело V9, способное связывать фактор роста эндотелия сосудов человека и блокировать его действие. Описаны нуклеотидная последовательность, кодирующая наноантитело V9, и вектор для его экспрессии с дополнительным(и) эпитопом(ами) на С-конце для детекции и выделения и сигнальным пептидом на N-конце. Раскрыты: способ получения наноантитела V9, способ ингибирования пролиферации эндотелиальных клеток с помощью наноантитела V9, а также применение наноантитела V9 для качественного и количественного определения VEGF в образце. Использование изобретения обеспечивает высокоаффинные нейтрализующие моновалентные одноцепочечные наноантитела, более устойчивые к внешним факторам (температура, рН) и более дешевые в производстве по сравнению с классическими антителами к VEGF, что может найти применение в медицине для лечения и диагностики заболеваний, связанных с регуляцией активности фактора роста эндотелия сосудов (VEGF). 6 н. и 1 з.п. ф-лы, 7 ил.</description><language>eng ; rus</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MANUFACTURE OR TREATMENT THEREOF ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS ; NANOTECHNOLOGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PERFORMING OPERATIONS ; PHYSICS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100727&DB=EPODOC&CC=RU&NR=2395521C1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100727&DB=EPODOC&CC=RU&NR=2395521C1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VJATCHANIN ANTON SERGEEVICH</creatorcontrib><creatorcontrib>KIBARDIN ALEKSEJ VLADIMIROVICH</creatorcontrib><creatorcontrib>LARIN SERGEJ SERGEEVICH</creatorcontrib><creatorcontrib>ZAKHAROVA ELENA SERGEEVNA</creatorcontrib><creatorcontrib>KOROBKO ELENA VLADIMIROVNA</creatorcontrib><creatorcontrib>KALINICHENKO SVETLANA VIKTOROVNA</creatorcontrib><creatorcontrib>IVANOVA TAT'JANA IL'INICHNA</creatorcontrib><creatorcontrib>TILLIB SERGEJ VLADIMIROVICH</creatorcontrib><creatorcontrib>GEORGIEV GEORGIJ PAVLOVICH</creatorcontrib><creatorcontrib>KOROBKO IGOR' VIKTOROVICH</creatorcontrib><creatorcontrib>GNUCHEV NIKOLAJ VASIL'EVICH</creatorcontrib><creatorcontrib>VIKHREVA POLINA NIKITICHNA</creatorcontrib><title>VEGF BINDING V9 NANOANTIBODY AND METHOD OF OBTAINING SAID ANTIBODY, V9-CODING NUCLEOTIDE SEQUENCE AND VECTOR CONTAINING SAID SEQUENCE, ENDOTHELIAL CELL PROLIFERATION INHIBITION METHOD</title><description>FIELD: chemistry. ^ SUBSTANCE: invention relates to immunology and biotechnology. The invention describes a nucleotide sequence which codes the V9 nanoantibody and its expression vector with extra epitope(s) on the C-end for detection and extraction and a signal peptide on the N-end. The invention discloses a method of obtaining the V9 nanoantibody, a method of inhibiting proliferation of endothelial cells using the V9 nanoantibody, as well as use of the V9 nanoantibody for qualitative and quantitative determination of VEGF in a sample. Use of the invention provides high-affinity neutralising monovalent single-strand nanoantibodies which are more resistant to external factors (temperature, pH) and cheaper to produce compared to conventional VEGF antibodies, which can be useful in medicine for treating and diagnosing diseases associated with regulation of the activity of the vascular endothelial growth factor (VEGF). ^ EFFECT: invention discloses a monomer single-strand V9 nanoantibody which can bind and inhibit the human vascular endothelial growth factor. ^ 7 cl, 7 dwg, 7 ex Изобретение относится к иммунологии и биотехнологии. Предложено мономерное одноцепочечное наноантитело V9, способное связывать фактор роста эндотелия сосудов человека и блокировать его действие. Описаны нуклеотидная последовательность, кодирующая наноантитело V9, и вектор для его экспрессии с дополнительным(и) эпитопом(ами) на С-конце для детекции и выделения и сигнальным пептидом на N-конце. Раскрыты: способ получения наноантитела V9, способ ингибирования пролиферации эндотелиальных клеток с помощью наноантитела V9, а также применение наноантитела V9 для качественного и количественного определения VEGF в образце. Использование изобретения обеспечивает высокоаффинные нейтрализующие моновалентные одноцепочечные наноантитела, более устойчивые к внешним факторам (температура, рН) и более дешевые в производстве по сравнению с классическими антителами к VEGF, что может найти применение в медицине для лечения и диагностики заболеваний, связанных с регуляцией активности фактора роста эндотелия сосудов (VEGF). 6 н. и 1 з.п. ф-лы, 7 ил.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MANUFACTURE OR TREATMENT THEREOF</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS</subject><subject>NANOTECHNOLOGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjjsOwjAQRNNQIOAOe4CkCIgipT9rspLZBeNEokIImQoBEtyN6wGBFHRUM8WbpxlmjxYXDjSxJV5AWwErFsWRtNgtKLawxFiLBXEgOiriN7dRZKGn8tesMNIJuDEeJZJF2OC6QTbYSVo0UQIY4R9Fz-SAbCXW6El5MOg9rIJ4chhUJGEgrklTVz9_xtnguD_d0uSbowwcRlMX6XrZpdt1f0jndN-FZjqr5vNpacrZH8gT6JBKhw</recordid><startdate>20100727</startdate><enddate>20100727</enddate><creator>VJATCHANIN ANTON SERGEEVICH</creator><creator>KIBARDIN ALEKSEJ VLADIMIROVICH</creator><creator>LARIN SERGEJ SERGEEVICH</creator><creator>ZAKHAROVA ELENA SERGEEVNA</creator><creator>KOROBKO ELENA VLADIMIROVNA</creator><creator>KALINICHENKO SVETLANA VIKTOROVNA</creator><creator>IVANOVA TAT'JANA IL'INICHNA</creator><creator>TILLIB SERGEJ VLADIMIROVICH</creator><creator>GEORGIEV GEORGIJ PAVLOVICH</creator><creator>KOROBKO IGOR' VIKTOROVICH</creator><creator>GNUCHEV NIKOLAJ VASIL'EVICH</creator><creator>VIKHREVA POLINA NIKITICHNA</creator><scope>EVB</scope></search><sort><creationdate>20100727</creationdate><title>VEGF BINDING V9 NANOANTIBODY AND METHOD OF OBTAINING SAID ANTIBODY, V9-CODING NUCLEOTIDE SEQUENCE AND VECTOR CONTAINING SAID SEQUENCE, ENDOTHELIAL CELL PROLIFERATION INHIBITION METHOD</title><author>VJATCHANIN ANTON SERGEEVICH ; KIBARDIN ALEKSEJ VLADIMIROVICH ; LARIN SERGEJ SERGEEVICH ; ZAKHAROVA ELENA SERGEEVNA ; KOROBKO ELENA VLADIMIROVNA ; KALINICHENKO SVETLANA VIKTOROVNA ; IVANOVA TAT'JANA IL'INICHNA ; TILLIB SERGEJ VLADIMIROVICH ; GEORGIEV GEORGIJ PAVLOVICH ; KOROBKO IGOR' VIKTOROVICH ; GNUCHEV NIKOLAJ VASIL'EVICH ; VIKHREVA POLINA NIKITICHNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2395521C13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2010</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MANUFACTURE OR TREATMENT THEREOF</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS</topic><topic>NANOTECHNOLOGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>VJATCHANIN ANTON SERGEEVICH</creatorcontrib><creatorcontrib>KIBARDIN ALEKSEJ VLADIMIROVICH</creatorcontrib><creatorcontrib>LARIN SERGEJ SERGEEVICH</creatorcontrib><creatorcontrib>ZAKHAROVA ELENA SERGEEVNA</creatorcontrib><creatorcontrib>KOROBKO ELENA VLADIMIROVNA</creatorcontrib><creatorcontrib>KALINICHENKO SVETLANA VIKTOROVNA</creatorcontrib><creatorcontrib>IVANOVA TAT'JANA IL'INICHNA</creatorcontrib><creatorcontrib>TILLIB SERGEJ VLADIMIROVICH</creatorcontrib><creatorcontrib>GEORGIEV GEORGIJ PAVLOVICH</creatorcontrib><creatorcontrib>KOROBKO IGOR' VIKTOROVICH</creatorcontrib><creatorcontrib>GNUCHEV NIKOLAJ VASIL'EVICH</creatorcontrib><creatorcontrib>VIKHREVA POLINA NIKITICHNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VJATCHANIN ANTON SERGEEVICH</au><au>KIBARDIN ALEKSEJ VLADIMIROVICH</au><au>LARIN SERGEJ SERGEEVICH</au><au>ZAKHAROVA ELENA SERGEEVNA</au><au>KOROBKO ELENA VLADIMIROVNA</au><au>KALINICHENKO SVETLANA VIKTOROVNA</au><au>IVANOVA TAT'JANA IL'INICHNA</au><au>TILLIB SERGEJ VLADIMIROVICH</au><au>GEORGIEV GEORGIJ PAVLOVICH</au><au>KOROBKO IGOR' VIKTOROVICH</au><au>GNUCHEV NIKOLAJ VASIL'EVICH</au><au>VIKHREVA POLINA NIKITICHNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>VEGF BINDING V9 NANOANTIBODY AND METHOD OF OBTAINING SAID ANTIBODY, V9-CODING NUCLEOTIDE SEQUENCE AND VECTOR CONTAINING SAID SEQUENCE, ENDOTHELIAL CELL PROLIFERATION INHIBITION METHOD</title><date>2010-07-27</date><risdate>2010</risdate><abstract>FIELD: chemistry. ^ SUBSTANCE: invention relates to immunology and biotechnology. The invention describes a nucleotide sequence which codes the V9 nanoantibody and its expression vector with extra epitope(s) on the C-end for detection and extraction and a signal peptide on the N-end. The invention discloses a method of obtaining the V9 nanoantibody, a method of inhibiting proliferation of endothelial cells using the V9 nanoantibody, as well as use of the V9 nanoantibody for qualitative and quantitative determination of VEGF in a sample. Use of the invention provides high-affinity neutralising monovalent single-strand nanoantibodies which are more resistant to external factors (temperature, pH) and cheaper to produce compared to conventional VEGF antibodies, which can be useful in medicine for treating and diagnosing diseases associated with regulation of the activity of the vascular endothelial growth factor (VEGF). ^ EFFECT: invention discloses a monomer single-strand V9 nanoantibody which can bind and inhibit the human vascular endothelial growth factor. ^ 7 cl, 7 dwg, 7 ex Изобретение относится к иммунологии и биотехнологии. Предложено мономерное одноцепочечное наноантитело V9, способное связывать фактор роста эндотелия сосудов человека и блокировать его действие. Описаны нуклеотидная последовательность, кодирующая наноантитело V9, и вектор для его экспрессии с дополнительным(и) эпитопом(ами) на С-конце для детекции и выделения и сигнальным пептидом на N-конце. Раскрыты: способ получения наноантитела V9, способ ингибирования пролиферации эндотелиальных клеток с помощью наноантитела V9, а также применение наноантитела V9 для качественного и количественного определения VEGF в образце. Использование изобретения обеспечивает высокоаффинные нейтрализующие моновалентные одноцепочечные наноантитела, более устойчивые к внешним факторам (температура, рН) и более дешевые в производстве по сравнению с классическими антителами к VEGF, что может найти применение в медицине для лечения и диагностики заболеваний, связанных с регуляцией активности фактора роста эндотелия сосудов (VEGF). 6 н. и 1 з.п. ф-лы, 7 ил.</abstract><oa>free_for_read</oa></addata></record>
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MANUFACTURE OR TREATMENT THEREOF MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS NANOTECHNOLOGY ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING TRANSPORTING VINEGAR WINE
title	VEGF BINDING V9 NANOANTIBODY AND METHOD OF OBTAINING SAID ANTIBODY, V9-CODING NUCLEOTIDE SEQUENCE AND VECTOR CONTAINING SAID SEQUENCE, ENDOTHELIAL CELL PROLIFERATION INHIBITION METHOD
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