METHOD OF PICAMILONUM-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, particularly to experimental cardiology and pharmacology. It implies simulation of endothelial dysfunction in Wistar albino male rats in experiment through daily intraperitoneal introduction of N-nitro-L-arginine methyl ester in a dose 25 m...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; rus |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | BELOUS ALEKSANDR SERGEEVICH GLADCHENKO MIKHAIL PETROVICH BABKO ANNA VLADIMIROVNA KOCHKAROV VLADIMIR ISKHAKOVICH NOVIKOVA MARINA JUR'EVNA GUDYREV OLEG SERGEEVICH ARTJUSHKOVA ELENA BORISOVNA TSEPELEV VASILIJ JUR'EVICH DANILENKO LJUDMILA MIKHAJLOVNA POKROVSKIJ MIKHAIL VLADIMIROVICH ERSHOV IL'JA NIKOLAEVICH TSYBUL'SKIJ IGOR' VALER'EVICH NOVIKOV OLEG OLEGOVICH GUREEV VLADIMIR VLADIMIROVICH KOROKIN MIKHAIL VIKTOROVICH KHARDIKOVA ELENA MIKHAJLOVNA LUCHKINA ELENA VADIMOVNA POKROVSKAJA TAT'JANA GRIGOR'EVNA |
| description | FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, particularly to experimental cardiology and pharmacology. It implies simulation of endothelial dysfunction in Wistar albino male rats in experiment through daily intraperitoneal introduction of N-nitro-L-arginine methyl ester in a dose 25 mg/kg within 7 days. It is followed with daily intragastric introduction of Picamilonum 30 mg/kg within next 7 days. ^ EFFECT: method provides effective correction of endothelial dysfunction in specific simulation environment. ^ 1 ex, 2 tbl
Изобретение относится к медицине, в частности к экспериментальной кардиологии и фармакологии. Для этого в эксперименте белым крысам самцам линии Wistar моделируют эндотелиальную дисфункцию путем ежедневного внутрибрюшинного введения в течение 7 суток N-нитро-L-аргинин метилового эфира в дозе 25 мг/кг. Затем в течение последующих 7 суток ежедневно вводят пикамилон в дозе 30 мг/кг внутрижелудочно. Способ обеспечивает эффективную коррекцию эндотелиальной дисфункции в специфических условиях моделирования. 2 табл. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_RU2364393C1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>RU2364393C1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_RU2364393C13</originalsourceid><addsrcrecordid>eNqNi0EKwjAQRbtxIeod5gJdaERwGScTOpBMJCZgV6VI3ChaqPfHih7A1fvw_ptXN0-pCQaChSOj9uyCZF8f9IkMYIiRMHGQjycxITXkWDsw7clm-SoWcLVoT9MyGadOOEVGCGc2BIYsI5Ngu6xm1_4-ltWPiwosJWzqMjy7Mg79pTzKq4t5o3ZbtVe4Vn9c3kphNgw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHOD OF PICAMILONUM-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY</title><source>esp@cenet</source><creator>BELOUS ALEKSANDR SERGEEVICH ; GLADCHENKO MIKHAIL PETROVICH ; BABKO ANNA VLADIMIROVNA ; KOCHKAROV VLADIMIR ISKHAKOVICH ; NOVIKOVA MARINA JUR'EVNA ; GUDYREV OLEG SERGEEVICH ; ARTJUSHKOVA ELENA BORISOVNA ; TSEPELEV VASILIJ JUR'EVICH ; DANILENKO LJUDMILA MIKHAJLOVNA ; POKROVSKIJ MIKHAIL VLADIMIROVICH ; ERSHOV IL'JA NIKOLAEVICH ; TSYBUL'SKIJ IGOR' VALER'EVICH ; NOVIKOV OLEG OLEGOVICH ; GUREEV VLADIMIR VLADIMIROVICH ; KOROKIN MIKHAIL VIKTOROVICH ; KHARDIKOVA ELENA MIKHAJLOVNA ; LUCHKINA ELENA VADIMOVNA ; POKROVSKAJA TAT'JANA GRIGOR'EVNA</creator><creatorcontrib>BELOUS ALEKSANDR SERGEEVICH ; GLADCHENKO MIKHAIL PETROVICH ; BABKO ANNA VLADIMIROVNA ; KOCHKAROV VLADIMIR ISKHAKOVICH ; NOVIKOVA MARINA JUR'EVNA ; GUDYREV OLEG SERGEEVICH ; ARTJUSHKOVA ELENA BORISOVNA ; TSEPELEV VASILIJ JUR'EVICH ; DANILENKO LJUDMILA MIKHAJLOVNA ; POKROVSKIJ MIKHAIL VLADIMIROVICH ; ERSHOV IL'JA NIKOLAEVICH ; TSYBUL'SKIJ IGOR' VALER'EVICH ; NOVIKOV OLEG OLEGOVICH ; GUREEV VLADIMIR VLADIMIROVICH ; KOROKIN MIKHAIL VIKTOROVICH ; KHARDIKOVA ELENA MIKHAJLOVNA ; LUCHKINA ELENA VADIMOVNA ; POKROVSKAJA TAT'JANA GRIGOR'EVNA</creatorcontrib><description>FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, particularly to experimental cardiology and pharmacology. It implies simulation of endothelial dysfunction in Wistar albino male rats in experiment through daily intraperitoneal introduction of N-nitro-L-arginine methyl ester in a dose 25 mg/kg within 7 days. It is followed with daily intragastric introduction of Picamilonum 30 mg/kg within next 7 days. ^ EFFECT: method provides effective correction of endothelial dysfunction in specific simulation environment. ^ 1 ex, 2 tbl
Изобретение относится к медицине, в частности к экспериментальной кардиологии и фармакологии. Для этого в эксперименте белым крысам самцам линии Wistar моделируют эндотелиальную дисфункцию путем ежедневного внутрибрюшинного введения в течение 7 суток N-нитро-L-аргинин метилового эфира в дозе 25 мг/кг. Затем в течение последующих 7 суток ежедневно вводят пикамилон в дозе 30 мг/кг внутрижелудочно. Способ обеспечивает эффективную коррекцию эндотелиальной дисфункции в специфических условиях моделирования. 2 табл.</description><language>eng ; rus</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090820&DB=EPODOC&CC=RU&NR=2364393C1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090820&DB=EPODOC&CC=RU&NR=2364393C1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BELOUS ALEKSANDR SERGEEVICH</creatorcontrib><creatorcontrib>GLADCHENKO MIKHAIL PETROVICH</creatorcontrib><creatorcontrib>BABKO ANNA VLADIMIROVNA</creatorcontrib><creatorcontrib>KOCHKAROV VLADIMIR ISKHAKOVICH</creatorcontrib><creatorcontrib>NOVIKOVA MARINA JUR'EVNA</creatorcontrib><creatorcontrib>GUDYREV OLEG SERGEEVICH</creatorcontrib><creatorcontrib>ARTJUSHKOVA ELENA BORISOVNA</creatorcontrib><creatorcontrib>TSEPELEV VASILIJ JUR'EVICH</creatorcontrib><creatorcontrib>DANILENKO LJUDMILA MIKHAJLOVNA</creatorcontrib><creatorcontrib>POKROVSKIJ MIKHAIL VLADIMIROVICH</creatorcontrib><creatorcontrib>ERSHOV IL'JA NIKOLAEVICH</creatorcontrib><creatorcontrib>TSYBUL'SKIJ IGOR' VALER'EVICH</creatorcontrib><creatorcontrib>NOVIKOV OLEG OLEGOVICH</creatorcontrib><creatorcontrib>GUREEV VLADIMIR VLADIMIROVICH</creatorcontrib><creatorcontrib>KOROKIN MIKHAIL VIKTOROVICH</creatorcontrib><creatorcontrib>KHARDIKOVA ELENA MIKHAJLOVNA</creatorcontrib><creatorcontrib>LUCHKINA ELENA VADIMOVNA</creatorcontrib><creatorcontrib>POKROVSKAJA TAT'JANA GRIGOR'EVNA</creatorcontrib><title>METHOD OF PICAMILONUM-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY</title><description>FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, particularly to experimental cardiology and pharmacology. It implies simulation of endothelial dysfunction in Wistar albino male rats in experiment through daily intraperitoneal introduction of N-nitro-L-arginine methyl ester in a dose 25 mg/kg within 7 days. It is followed with daily intragastric introduction of Picamilonum 30 mg/kg within next 7 days. ^ EFFECT: method provides effective correction of endothelial dysfunction in specific simulation environment. ^ 1 ex, 2 tbl
Изобретение относится к медицине, в частности к экспериментальной кардиологии и фармакологии. Для этого в эксперименте белым крысам самцам линии Wistar моделируют эндотелиальную дисфункцию путем ежедневного внутрибрюшинного введения в течение 7 суток N-нитро-L-аргинин метилового эфира в дозе 25 мг/кг. Затем в течение последующих 7 суток ежедневно вводят пикамилон в дозе 30 мг/кг внутрижелудочно. Способ обеспечивает эффективную коррекцию эндотелиальной дисфункции в специфических условиях моделирования. 2 табл.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EKwjAQRbtxIeod5gJdaERwGScTOpBMJCZgV6VI3ChaqPfHih7A1fvw_ptXN0-pCQaChSOj9uyCZF8f9IkMYIiRMHGQjycxITXkWDsw7clm-SoWcLVoT9MyGadOOEVGCGc2BIYsI5Ngu6xm1_4-ltWPiwosJWzqMjy7Mg79pTzKq4t5o3ZbtVe4Vn9c3kphNgw</recordid><startdate>20090820</startdate><enddate>20090820</enddate><creator>BELOUS ALEKSANDR SERGEEVICH</creator><creator>GLADCHENKO MIKHAIL PETROVICH</creator><creator>BABKO ANNA VLADIMIROVNA</creator><creator>KOCHKAROV VLADIMIR ISKHAKOVICH</creator><creator>NOVIKOVA MARINA JUR'EVNA</creator><creator>GUDYREV OLEG SERGEEVICH</creator><creator>ARTJUSHKOVA ELENA BORISOVNA</creator><creator>TSEPELEV VASILIJ JUR'EVICH</creator><creator>DANILENKO LJUDMILA MIKHAJLOVNA</creator><creator>POKROVSKIJ MIKHAIL VLADIMIROVICH</creator><creator>ERSHOV IL'JA NIKOLAEVICH</creator><creator>TSYBUL'SKIJ IGOR' VALER'EVICH</creator><creator>NOVIKOV OLEG OLEGOVICH</creator><creator>GUREEV VLADIMIR VLADIMIROVICH</creator><creator>KOROKIN MIKHAIL VIKTOROVICH</creator><creator>KHARDIKOVA ELENA MIKHAJLOVNA</creator><creator>LUCHKINA ELENA VADIMOVNA</creator><creator>POKROVSKAJA TAT'JANA GRIGOR'EVNA</creator><scope>EVB</scope></search><sort><creationdate>20090820</creationdate><title>METHOD OF PICAMILONUM-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY</title><author>BELOUS ALEKSANDR SERGEEVICH ; GLADCHENKO MIKHAIL PETROVICH ; BABKO ANNA VLADIMIROVNA ; KOCHKAROV VLADIMIR ISKHAKOVICH ; NOVIKOVA MARINA JUR'EVNA ; GUDYREV OLEG SERGEEVICH ; ARTJUSHKOVA ELENA BORISOVNA ; TSEPELEV VASILIJ JUR'EVICH ; DANILENKO LJUDMILA MIKHAJLOVNA ; POKROVSKIJ MIKHAIL VLADIMIROVICH ; ERSHOV IL'JA NIKOLAEVICH ; TSYBUL'SKIJ IGOR' VALER'EVICH ; NOVIKOV OLEG OLEGOVICH ; GUREEV VLADIMIR VLADIMIROVICH ; KOROKIN MIKHAIL VIKTOROVICH ; KHARDIKOVA ELENA MIKHAJLOVNA ; LUCHKINA ELENA VADIMOVNA ; POKROVSKAJA TAT'JANA GRIGOR'EVNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2364393C13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2009</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BELOUS ALEKSANDR SERGEEVICH</creatorcontrib><creatorcontrib>GLADCHENKO MIKHAIL PETROVICH</creatorcontrib><creatorcontrib>BABKO ANNA VLADIMIROVNA</creatorcontrib><creatorcontrib>KOCHKAROV VLADIMIR ISKHAKOVICH</creatorcontrib><creatorcontrib>NOVIKOVA MARINA JUR'EVNA</creatorcontrib><creatorcontrib>GUDYREV OLEG SERGEEVICH</creatorcontrib><creatorcontrib>ARTJUSHKOVA ELENA BORISOVNA</creatorcontrib><creatorcontrib>TSEPELEV VASILIJ JUR'EVICH</creatorcontrib><creatorcontrib>DANILENKO LJUDMILA MIKHAJLOVNA</creatorcontrib><creatorcontrib>POKROVSKIJ MIKHAIL VLADIMIROVICH</creatorcontrib><creatorcontrib>ERSHOV IL'JA NIKOLAEVICH</creatorcontrib><creatorcontrib>TSYBUL'SKIJ IGOR' VALER'EVICH</creatorcontrib><creatorcontrib>NOVIKOV OLEG OLEGOVICH</creatorcontrib><creatorcontrib>GUREEV VLADIMIR VLADIMIROVICH</creatorcontrib><creatorcontrib>KOROKIN MIKHAIL VIKTOROVICH</creatorcontrib><creatorcontrib>KHARDIKOVA ELENA MIKHAJLOVNA</creatorcontrib><creatorcontrib>LUCHKINA ELENA VADIMOVNA</creatorcontrib><creatorcontrib>POKROVSKAJA TAT'JANA GRIGOR'EVNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BELOUS ALEKSANDR SERGEEVICH</au><au>GLADCHENKO MIKHAIL PETROVICH</au><au>BABKO ANNA VLADIMIROVNA</au><au>KOCHKAROV VLADIMIR ISKHAKOVICH</au><au>NOVIKOVA MARINA JUR'EVNA</au><au>GUDYREV OLEG SERGEEVICH</au><au>ARTJUSHKOVA ELENA BORISOVNA</au><au>TSEPELEV VASILIJ JUR'EVICH</au><au>DANILENKO LJUDMILA MIKHAJLOVNA</au><au>POKROVSKIJ MIKHAIL VLADIMIROVICH</au><au>ERSHOV IL'JA NIKOLAEVICH</au><au>TSYBUL'SKIJ IGOR' VALER'EVICH</au><au>NOVIKOV OLEG OLEGOVICH</au><au>GUREEV VLADIMIR VLADIMIROVICH</au><au>KOROKIN MIKHAIL VIKTOROVICH</au><au>KHARDIKOVA ELENA MIKHAJLOVNA</au><au>LUCHKINA ELENA VADIMOVNA</au><au>POKROVSKAJA TAT'JANA GRIGOR'EVNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF PICAMILONUM-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY</title><date>2009-08-20</date><risdate>2009</risdate><abstract>FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, particularly to experimental cardiology and pharmacology. It implies simulation of endothelial dysfunction in Wistar albino male rats in experiment through daily intraperitoneal introduction of N-nitro-L-arginine methyl ester in a dose 25 mg/kg within 7 days. It is followed with daily intragastric introduction of Picamilonum 30 mg/kg within next 7 days. ^ EFFECT: method provides effective correction of endothelial dysfunction in specific simulation environment. ^ 1 ex, 2 tbl
Изобретение относится к медицине, в частности к экспериментальной кардиологии и фармакологии. Для этого в эксперименте белым крысам самцам линии Wistar моделируют эндотелиальную дисфункцию путем ежедневного внутрибрюшинного введения в течение 7 суток N-нитро-L-аргинин метилового эфира в дозе 25 мг/кг. Затем в течение последующих 7 суток ежедневно вводят пикамилон в дозе 30 мг/кг внутрижелудочно. Способ обеспечивает эффективную коррекцию эндотелиальной дисфункции в специфических условиях моделирования. 2 табл.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; rus |
| recordid | cdi_epo_espacenet_RU2364393C1 |
| source | esp@cenet |
| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | METHOD OF PICAMILONUM-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T17%3A45%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=BELOUS%20ALEKSANDR%20SERGEEVICH&rft.date=2009-08-20&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ERU2364393C1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |