ANALOGUES OF QUINAZOLINE AS INHIBITORS OF RECEPTOR TYROSINE KINASES
FIELD: medicine. ^ SUBSTANCE: invention offers analogues of quinazoline of the formula I ^ where A is bound at least with one of atoms of carbon in position 6 or 7 of the dicyclic ring; X represents N. A represents the group Q or Z including tautomeric group Z form where Q and Z, have the formulas r...
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| creator | UOLLAS EHLAJ TOPALOV DZHORDZH LISSIKATOS DZHOZEF CHAO CHZHAN BAKMELTER ALEKSANDR |
| description | FIELD: medicine. ^ SUBSTANCE: invention offers analogues of quinazoline of the formula I ^ where A is bound at least with one of atoms of carbon in position 6 or 7 of the dicyclic ring; X represents N. A represents the group Q or Z including tautomeric group Z form where Q and Z, have the formulas resulted more low in which symbols and radicals, have the value specified in item 1 of the formula of the invention. R1 represents phenyl, substituted -(G)nOAr or -O(G)nAr and where phenyl is unessentially replaced by halogen or C1-C10alkyl; where G represents C1-C4alkylene, n is peer 0 or 1. And Ar represents phenyl either pyridyl or thiazolyl where Ar is unessentially substituted by 1-2 substituents chosen from halogen or C1-C10alkyl; R2 and R3 represent N. The bonds of the formula I are inhibitors of the receptor tyrosine kinases of type 1. The invention includes also a way of treatment of hyperproliferative diseases, such as a cancer, application of bonds of the formula 1 in manufacture of medical products and pharmaceutical composition on the basis of these bonds. ^ EFFECT: rising of efficiency of a composition and the method of treatment. ^ 14 cl, 6 dwg, 63 ex |
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A represents the group Q or Z including tautomeric group Z form where Q and Z, have the formulas resulted more low in which symbols and radicals, have the value specified in item 1 of the formula of the invention. R1 represents phenyl, substituted -(G)nOAr or -O(G)nAr and where phenyl is unessentially replaced by halogen or C1-C10alkyl; where G represents C1-C4alkylene, n is peer 0 or 1. And Ar represents phenyl either pyridyl or thiazolyl where Ar is unessentially substituted by 1-2 substituents chosen from halogen or C1-C10alkyl; R2 and R3 represent N. The bonds of the formula I are inhibitors of the receptor tyrosine kinases of type 1. The invention includes also a way of treatment of hyperproliferative diseases, such as a cancer, application of bonds of the formula 1 in manufacture of medical products and pharmaceutical composition on the basis of these bonds. ^ EFFECT: rising of efficiency of a composition and the method of treatment. ^ 14 cl, 6 dwg, 63 ex</description><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090327&DB=EPODOC&CC=RU&NR=2350605C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090327&DB=EPODOC&CC=RU&NR=2350605C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>UOLLAS EHLAJ</creatorcontrib><creatorcontrib>TOPALOV DZHORDZH</creatorcontrib><creatorcontrib>LISSIKATOS DZHOZEF</creatorcontrib><creatorcontrib>CHAO CHZHAN</creatorcontrib><creatorcontrib>BAKMELTER ALEKSANDR</creatorcontrib><title>ANALOGUES OF QUINAZOLINE AS INHIBITORS OF RECEPTOR TYROSINE KINASES</title><description>FIELD: medicine. ^ SUBSTANCE: invention offers analogues of quinazoline of the formula I ^ where A is bound at least with one of atoms of carbon in position 6 or 7 of the dicyclic ring; X represents N. 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The invention includes also a way of treatment of hyperproliferative diseases, such as a cancer, application of bonds of the formula 1 in manufacture of medical products and pharmaceutical composition on the basis of these bonds. ^ EFFECT: rising of efficiency of a composition and the method of treatment. ^ 14 cl, 6 dwg, 63 ex</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANALOGUES OF QUINAZOLINE AS INHIBITORS OF RECEPTOR TYROSINE KINASES |
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