DERIVATIVES OF TETRAHYDROISOQUINOLYLACETAMIDE AS OREXIN RECEPTOR ANTAGONISTS

FIELD: chemistry. ^ SUBSTANCE: present invention pertains to compounds with formula (I) in which R1, R2, R3, R4 independently represent hydrogen, C1-C4alkyl, C2-C4alkenyl, C1-C4alkoxy, C2-C3alkenyloxy, C3-C6cycloalkyloxy, or R1 and R2 together, as well as R2 and R3 together or R3 and R4 together with a phenyl ring, to which they are bonded, form a five-, six- or seven-member ring, containing one or two oxygen atoms; R5 represents phenylethyl, unsubstituted or containing one, two or three substitutes, where the substitutes independently represent C1-C4alkyl, C1-C4alkoxy, C2-C4alkenyl, trifluoromethyl, trifluoromethoxym difluoromethoxy or halogen; and its pharmaceutical salts. ^ EFFECT: obtaining new compounds used as orexin receptor antagonists. ^ 9 cl, 77 ex