HISTAMINE RECEPTOR BLOCKERS FOR PHARMACEUTICAL COMPOSITIONS OF ANTIALLERGIC AND AUTOIMMUNE EFFECT
FIELD: chemistry. ^ SUBSTANCE: invention concerns new histamine receptor blockers in the form of 2,3,4,5-tetrahydro-1H-pyrido-[3,4-b]indoles of the general formula 1 , where: R1 is an aminogroup substitute selected out of optionally substituted C1-C5alkyl; R2 i is one or several same or different su...
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creator | IVASHCHENKO ALEKSANDR VASIL'EVICH MIT'KIN OLEG DMITRIEVICH KRAVCHENKO DMITRIJ VLADIMIROVICH SAVCHUK NIKOLAJ FILIPPOVICH TKACHENKO SERGEJ EVGEN'EVICH FROLOV EVGENIJ BORISOVICH OKUN' IL'JA MATUSOVICH IVASHCHENKO ANDREJ ALEKSANDROVICH |
description | FIELD: chemistry. ^ SUBSTANCE: invention concerns new histamine receptor blockers in the form of 2,3,4,5-tetrahydro-1H-pyrido-[3,4-b]indoles of the general formula 1 , where: R1 is an aminogroup substitute selected out of optionally substituted C1-C5alkyl; R2 i is one or several same or different substitutes selected out of hydrogen, halogen, C1-C3 alkyl, CF3; Ar is phenyl or 5-6-member heterocycle containing 1-2 nitrogen or sulphur atoms in the cycle, unsubstituted or substituted by halogen, C1-C5alkyl, C1-C5alkoxy, substituted aminogroup or trifluormethyl; W is CH2 group optionally substituted CH2CH2 group or optionally substituted CH=CH group. ^ EFFECT: enhanced antiallergic and autoimmune effect. ^ 4 tbl |
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R2 i is one or several same or different substitutes selected out of hydrogen, halogen, C1-C3 alkyl, CF3; Ar is phenyl or 5-6-member heterocycle containing 1-2 nitrogen or sulphur atoms in the cycle, unsubstituted or substituted by halogen, C1-C5alkyl, C1-C5alkoxy, substituted aminogroup or trifluormethyl; W is CH2 group optionally substituted CH2CH2 group or optionally substituted CH=CH group. ^ EFFECT: enhanced antiallergic and autoimmune effect. ^ 4 tbl</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | HISTAMINE RECEPTOR BLOCKERS FOR PHARMACEUTICAL COMPOSITIONS OF ANTIALLERGIC AND AUTOIMMUNE EFFECT |
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