HISTAMINE RECEPTOR BLOCKERS FOR PHARMACEUTICAL COMPOSITIONS OF ANTIALLERGIC AND AUTOIMMUNE EFFECT

FIELD: chemistry. ^ SUBSTANCE: invention concerns new histamine receptor blockers in the form of 2,3,4,5-tetrahydro-1H-pyrido-[3,4-b]indoles of the general formula 1 , where: R1 is an aminogroup substitute selected out of optionally substituted C1-C5alkyl; R2 i is one or several same or different su...

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Hauptverfasser: IVASHCHENKO ALEKSANDR VASIL'EVICH, MIT'KIN OLEG DMITRIEVICH, KRAVCHENKO DMITRIJ VLADIMIROVICH, SAVCHUK NIKOLAJ FILIPPOVICH, TKACHENKO SERGEJ EVGEN'EVICH, FROLOV EVGENIJ BORISOVICH, OKUN' IL'JA MATUSOVICH, IVASHCHENKO ANDREJ ALEKSANDROVICH
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creator IVASHCHENKO ALEKSANDR VASIL'EVICH
MIT'KIN OLEG DMITRIEVICH
KRAVCHENKO DMITRIJ VLADIMIROVICH
SAVCHUK NIKOLAJ FILIPPOVICH
TKACHENKO SERGEJ EVGEN'EVICH
FROLOV EVGENIJ BORISOVICH
OKUN' IL'JA MATUSOVICH
IVASHCHENKO ANDREJ ALEKSANDROVICH
description FIELD: chemistry. ^ SUBSTANCE: invention concerns new histamine receptor blockers in the form of 2,3,4,5-tetrahydro-1H-pyrido-[3,4-b]indoles of the general formula 1 , where: R1 is an aminogroup substitute selected out of optionally substituted C1-C5alkyl; R2 i is one or several same or different substitutes selected out of hydrogen, halogen, C1-C3 alkyl, CF3; Ar is phenyl or 5-6-member heterocycle containing 1-2 nitrogen or sulphur atoms in the cycle, unsubstituted or substituted by halogen, C1-C5alkyl, C1-C5alkoxy, substituted aminogroup or trifluormethyl; W is CH2 group optionally substituted CH2CH2 group or optionally substituted CH=CH group. ^ EFFECT: enhanced antiallergic and autoimmune effect. ^ 4 tbl
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title HISTAMINE RECEPTOR BLOCKERS FOR PHARMACEUTICAL COMPOSITIONS OF ANTIALLERGIC AND AUTOIMMUNE EFFECT
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