ASPOROGENOUS RECOMBINANT STRAIN Bacillus anthracis 55Delta-1S- (pUB110-1) AS PRODUCER OF ANTHRAX MICROORGANISM ANTIGEN

FIELD: biotechnology, microbiology. ^ SUBSTANCE: invention relates to the asporogenous recombinant strain B. anthracis 55DeltaTPA-1Spo- (pUB110PA-1) producing the anthrax microorganism protective antigen that is obtained by transformation of the strain B. anthrax 55DeltaTSpo- with DNA of hybrid plas...

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Hauptverfasser: MIKSHIS NATAL'JA IVANOVNA, SHULEPOV DMITRIJ VIKTOROVICH, POPOV JURIJ ALEKSEEVICH
Format: Patent
Sprache:eng ; rus
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Zusammenfassung:FIELD: biotechnology, microbiology. ^ SUBSTANCE: invention relates to the asporogenous recombinant strain B. anthracis 55DeltaTPA-1Spo- (pUB110PA-1) producing the anthrax microorganism protective antigen that is obtained by transformation of the strain B. anthrax 55DeltaTSpo- with DNA of hybrid plasmid pUB110PA-1. The strain is deposited in GK of pathogenic "Mikrob" at number KM-97, and this the strain is characterized by absence of ability for spores formation, stability of hybrid replicon and high level of production of the protective antigen that represents the main component of chemical anthrax vaccines. ^ EFFECT: valuable biological of strain. ^ 9 ex