IMPROVED METHOD FOR PREPARING ALPHA-POLYMORPHOUS ELETRIPTANE BROMOHYDRATE
FIELD: chemical technology. ^ SUBSTANCE: invention relates to a method for synthesis of alpha-polymorphous eletriptane bromohydrate that involves the following steps: (a) treatment of eletriptane solution in 2-butanone with hydrobromic acid and (b) distillation of azeotropic mixture 2-butanone/water...
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| creator | FARLONG PATRIK DZHOZEF KELLI KORNELIUS DZHOZEF OGILVI RONAL'D DZHEJMS RAJAN VINSENT |
| description | FIELD: chemical technology. ^ SUBSTANCE: invention relates to a method for synthesis of alpha-polymorphous eletriptane bromohydrate that involves the following steps: (a) treatment of eletriptane solution in 2-butanone with hydrobromic acid and (b) distillation of azeotropic mixture 2-butanone/water up to termination of formation of anhydrous alpha-polymorphous eletriptane bromohydrate. Also, invention relates to a method for preparing crystalline alpha-polymorphous form of eletriptane bromohydrate involving the following steps: (a) treatment of the parent eletriptane bromohydrate substance solution in mixture of 2-butanone and water, and (b) distillation of azeotropic mixture 2-butanone/water up to termination of formation of anhydrous alpha-polymorphous eletriptane bromohydrate. Product synthesized by claimed methods represents exclusively anhydrous eletriptane bromohydrate and prepared with the high yield, i. e. formation of other polymorphous forms or eletriptane bromohydrate solvates in realization of claimed methods do not occur. Invention provides decreasing working ability of the method in synthesis of alpha-polymorphous eletriptane bromohydrate provides high yield of alpha-polymorphous eletriptane bromohydrate. ^ EFFECT: improved method of synthesis. ^ 11 cl, 9 ex |
| format | Patent |
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Also, invention relates to a method for preparing crystalline alpha-polymorphous form of eletriptane bromohydrate involving the following steps: (a) treatment of the parent eletriptane bromohydrate substance solution in mixture of 2-butanone and water, and (b) distillation of azeotropic mixture 2-butanone/water up to termination of formation of anhydrous alpha-polymorphous eletriptane bromohydrate. Product synthesized by claimed methods represents exclusively anhydrous eletriptane bromohydrate and prepared with the high yield, i. e. formation of other polymorphous forms or eletriptane bromohydrate solvates in realization of claimed methods do not occur. Invention provides decreasing working ability of the method in synthesis of alpha-polymorphous eletriptane bromohydrate provides high yield of alpha-polymorphous eletriptane bromohydrate. ^ EFFECT: improved method of synthesis. ^ 11 cl, 9 ex</description><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080327&DB=EPODOC&CC=RU&NR=2320655C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080327&DB=EPODOC&CC=RU&NR=2320655C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FARLONG PATRIK DZHOZEF</creatorcontrib><creatorcontrib>KELLI KORNELIUS DZHOZEF</creatorcontrib><creatorcontrib>OGILVI RONAL'D DZHEJMS</creatorcontrib><creatorcontrib>RAJAN VINSENT</creatorcontrib><title>IMPROVED METHOD FOR PREPARING ALPHA-POLYMORPHOUS ELETRIPTANE BROMOHYDRATE</title><description>FIELD: chemical technology. ^ SUBSTANCE: invention relates to a method for synthesis of alpha-polymorphous eletriptane bromohydrate that involves the following steps: (a) treatment of eletriptane solution in 2-butanone with hydrobromic acid and (b) distillation of azeotropic mixture 2-butanone/water up to termination of formation of anhydrous alpha-polymorphous eletriptane bromohydrate. Also, invention relates to a method for preparing crystalline alpha-polymorphous form of eletriptane bromohydrate involving the following steps: (a) treatment of the parent eletriptane bromohydrate substance solution in mixture of 2-butanone and water, and (b) distillation of azeotropic mixture 2-butanone/water up to termination of formation of anhydrous alpha-polymorphous eletriptane bromohydrate. Product synthesized by claimed methods represents exclusively anhydrous eletriptane bromohydrate and prepared with the high yield, i. e. formation of other polymorphous forms or eletriptane bromohydrate solvates in realization of claimed methods do not occur. 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Also, invention relates to a method for preparing crystalline alpha-polymorphous form of eletriptane bromohydrate involving the following steps: (a) treatment of the parent eletriptane bromohydrate substance solution in mixture of 2-butanone and water, and (b) distillation of azeotropic mixture 2-butanone/water up to termination of formation of anhydrous alpha-polymorphous eletriptane bromohydrate. Product synthesized by claimed methods represents exclusively anhydrous eletriptane bromohydrate and prepared with the high yield, i. e. formation of other polymorphous forms or eletriptane bromohydrate solvates in realization of claimed methods do not occur. Invention provides decreasing working ability of the method in synthesis of alpha-polymorphous eletriptane bromohydrate provides high yield of alpha-polymorphous eletriptane bromohydrate. ^ EFFECT: improved method of synthesis. ^ 11 cl, 9 ex</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | IMPROVED METHOD FOR PREPARING ALPHA-POLYMORPHOUS ELETRIPTANE BROMOHYDRATE |
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