FLUORINATED CYCLOALKYL-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THEIR PREPARING, THEIR USING AS MEDICINAL AGENT AND MEDICINAL AGENT COMPRISING THEREOF
FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention relates to fluorinated cycloalkyl-substituted benzoylguanidines of the formula (I) wherein X means oxygen or sulfur atom or -NR6 wherein R6 means hydrogen atom, alkyl comprising 1, 2, 3 or 4 carbon atoms; m = 0, 1, 2 or 3; n = 0, 1, 2 or 3;...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Patent |
| Sprache: | eng ; rus |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | KLEEMANN KHAJNTS-VERNER |
| description | FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention relates to fluorinated cycloalkyl-substituted benzoylguanidines of the formula (I) wherein X means oxygen or sulfur atom or -NR6 wherein R6 means hydrogen atom, alkyl comprising 1, 2, 3 or 4 carbon atoms; m = 0, 1, 2 or 3; n = 0, 1, 2 or 3; p = 0, 1, 2 or 3; q = 1, 2 or 3; r = 0, 1, 2 or 3 and wherein sum m + n + p + q + r is 2 at least; R1 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R2 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R3 means -SOuR10 wherein u means 0, 1 or 2; R10 means alkyl comprising 1, 2, 3 or 4 carbon atoms; R4 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R5 means hydrogen, and their pharmaceutically tolerant salts. Also, invention relates to compounds of the formula (I) and/or their pharmaceutically tolerant salt used as a medicinal agent possessing inhibitory effect on activity of sodium-proton antiporters and designated for treatment of diseases mediated by this activity. Invention provides fluorinated cycloalkyl-substituted benzoylguanidines possessing inhibitory activity with respect to sodium-proton antiporters. ^ EFFECT: valuable medicinal properties of compound and medicinal agents, improved method of synthesis. ^ 9 cl, 2 ex |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_RU2305093C2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>RU2305093C2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_RU2305093C23</originalsourceid><addsrcrecordid>eNqNjbsOgjAYhVkcjPoO_wNAQiAOjqX9C42lJb0MsBBi6mSUBN_F17UaNhenk_PlXLbJi0uvjVDEIQPaU6mJPPcys76yTjj_wRWqQfey9kQJJhTaFFp0jWbAtQHXoDDQGexI3KnTFXgbDRAbo0zQeCCB1KgcEMV-GNVtZ8S3EdsGNd8nm-t0W8Jh1V0CHB1tsjA_xrDM0yXcw3M0vijzY34qaVH-EXkD_axChg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>FLUORINATED CYCLOALKYL-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THEIR PREPARING, THEIR USING AS MEDICINAL AGENT AND MEDICINAL AGENT COMPRISING THEREOF</title><source>esp@cenet</source><creator>KLEEMANN KHAJNTS-VERNER</creator><creatorcontrib>KLEEMANN KHAJNTS-VERNER</creatorcontrib><description>FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention relates to fluorinated cycloalkyl-substituted benzoylguanidines of the formula (I) wherein X means oxygen or sulfur atom or -NR6 wherein R6 means hydrogen atom, alkyl comprising 1, 2, 3 or 4 carbon atoms; m = 0, 1, 2 or 3; n = 0, 1, 2 or 3; p = 0, 1, 2 or 3; q = 1, 2 or 3; r = 0, 1, 2 or 3 and wherein sum m + n + p + q + r is 2 at least; R1 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R2 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R3 means -SOuR10 wherein u means 0, 1 or 2; R10 means alkyl comprising 1, 2, 3 or 4 carbon atoms; R4 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R5 means hydrogen, and their pharmaceutically tolerant salts. Also, invention relates to compounds of the formula (I) and/or their pharmaceutically tolerant salt used as a medicinal agent possessing inhibitory effect on activity of sodium-proton antiporters and designated for treatment of diseases mediated by this activity. Invention provides fluorinated cycloalkyl-substituted benzoylguanidines possessing inhibitory activity with respect to sodium-proton antiporters. ^ EFFECT: valuable medicinal properties of compound and medicinal agents, improved method of synthesis. ^ 9 cl, 2 ex</description><language>eng ; rus</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070827&DB=EPODOC&CC=RU&NR=2305093C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070827&DB=EPODOC&CC=RU&NR=2305093C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KLEEMANN KHAJNTS-VERNER</creatorcontrib><title>FLUORINATED CYCLOALKYL-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THEIR PREPARING, THEIR USING AS MEDICINAL AGENT AND MEDICINAL AGENT COMPRISING THEREOF</title><description>FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention relates to fluorinated cycloalkyl-substituted benzoylguanidines of the formula (I) wherein X means oxygen or sulfur atom or -NR6 wherein R6 means hydrogen atom, alkyl comprising 1, 2, 3 or 4 carbon atoms; m = 0, 1, 2 or 3; n = 0, 1, 2 or 3; p = 0, 1, 2 or 3; q = 1, 2 or 3; r = 0, 1, 2 or 3 and wherein sum m + n + p + q + r is 2 at least; R1 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R2 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R3 means -SOuR10 wherein u means 0, 1 or 2; R10 means alkyl comprising 1, 2, 3 or 4 carbon atoms; R4 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R5 means hydrogen, and their pharmaceutically tolerant salts. Also, invention relates to compounds of the formula (I) and/or their pharmaceutically tolerant salt used as a medicinal agent possessing inhibitory effect on activity of sodium-proton antiporters and designated for treatment of diseases mediated by this activity. Invention provides fluorinated cycloalkyl-substituted benzoylguanidines possessing inhibitory activity with respect to sodium-proton antiporters. ^ EFFECT: valuable medicinal properties of compound and medicinal agents, improved method of synthesis. ^ 9 cl, 2 ex</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjbsOgjAYhVkcjPoO_wNAQiAOjqX9C42lJb0MsBBi6mSUBN_F17UaNhenk_PlXLbJi0uvjVDEIQPaU6mJPPcys76yTjj_wRWqQfey9kQJJhTaFFp0jWbAtQHXoDDQGexI3KnTFXgbDRAbo0zQeCCB1KgcEMV-GNVtZ8S3EdsGNd8nm-t0W8Jh1V0CHB1tsjA_xrDM0yXcw3M0vijzY34qaVH-EXkD_axChg</recordid><startdate>20070827</startdate><enddate>20070827</enddate><creator>KLEEMANN KHAJNTS-VERNER</creator><scope>EVB</scope></search><sort><creationdate>20070827</creationdate><title>FLUORINATED CYCLOALKYL-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THEIR PREPARING, THEIR USING AS MEDICINAL AGENT AND MEDICINAL AGENT COMPRISING THEREOF</title><author>KLEEMANN KHAJNTS-VERNER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2305093C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2007</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KLEEMANN KHAJNTS-VERNER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KLEEMANN KHAJNTS-VERNER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FLUORINATED CYCLOALKYL-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THEIR PREPARING, THEIR USING AS MEDICINAL AGENT AND MEDICINAL AGENT COMPRISING THEREOF</title><date>2007-08-27</date><risdate>2007</risdate><abstract>FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention relates to fluorinated cycloalkyl-substituted benzoylguanidines of the formula (I) wherein X means oxygen or sulfur atom or -NR6 wherein R6 means hydrogen atom, alkyl comprising 1, 2, 3 or 4 carbon atoms; m = 0, 1, 2 or 3; n = 0, 1, 2 or 3; p = 0, 1, 2 or 3; q = 1, 2 or 3; r = 0, 1, 2 or 3 and wherein sum m + n + p + q + r is 2 at least; R1 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R2 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R3 means -SOuR10 wherein u means 0, 1 or 2; R10 means alkyl comprising 1, 2, 3 or 4 carbon atoms; R4 means hydrogen atom or alkyl comprising 1, 2, 3 or 4 carbon atoms; R5 means hydrogen, and their pharmaceutically tolerant salts. Also, invention relates to compounds of the formula (I) and/or their pharmaceutically tolerant salt used as a medicinal agent possessing inhibitory effect on activity of sodium-proton antiporters and designated for treatment of diseases mediated by this activity. Invention provides fluorinated cycloalkyl-substituted benzoylguanidines possessing inhibitory activity with respect to sodium-proton antiporters. ^ EFFECT: valuable medicinal properties of compound and medicinal agents, improved method of synthesis. ^ 9 cl, 2 ex</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; rus |
| recordid | cdi_epo_espacenet_RU2305093C2 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | FLUORINATED CYCLOALKYL-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THEIR PREPARING, THEIR USING AS MEDICINAL AGENT AND MEDICINAL AGENT COMPRISING THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T15%3A51%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KLEEMANN%20KHAJNTS-VERNER&rft.date=2007-08-27&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ERU2305093C2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |