ISOPROPYL-12-AROYL-2-HYDROXY-1,6-DIOXO-4-(3-PYRIDINYL)-7-PHENYL-1,3,6,7-TETRAHYDRO-2,5alpha-METHANO[1,4]DIAZEPINO[1,7alpha]-QUINOXALINE-5-CARBOXYLATES AND METHOD FOR THEIR PREPARING

ISOPROPYL-12-AROYL-2-HYDROXY-1,6-DIOXO-4-(3-PYRIDINYL)-7-PHENYL-1,3,6,7-TETRAHYDRO-2,5alpha-METHANO[1,4]DIAZEPINO[1,7alpha]-QUINOXALINE-5-CARBOXYLATES AND METHOD FOR THEIR PREPARING

FIELD: organic chemistry. ^ SUBSTANCE: invention relates to novel individual compounds of series 2,5a-methano[1,4]diazepino[1,7-a]-quinoxaline-5-carboxylates, namely, to isopropyl-12-aroyl-2-hydroxy-1,6-dioxo-4-(3-pyridinyl)-7-phenyl-1,3,6,7-tetrahydro-2,5a-methano[1,4]diazepino[1,7-a]-quinoxaline-5...

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Hauptverfasser: BOZDYREVA KSENIJA SERGEEVNA, MASLIVETS ANDREJ NIKOLAEVICH, ALEKSANDROVA GALINA ARSENT'EVNA
Format: Patent
Sprache:eng ; rus
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator BOZDYREVA KSENIJA SERGEEVNA
MASLIVETS ANDREJ NIKOLAEVICH
ALEKSANDROVA GALINA ARSENT'EVNA
description FIELD: organic chemistry. ^ SUBSTANCE: invention relates to novel individual compounds of series 2,5a-methano[1,4]diazepino[1,7-a]-quinoxaline-5-carboxylates, namely, to isopropyl-12-aroyl-2-hydroxy-1,6-dioxo-4-(3-pyridinyl)-7-phenyl-1,3,6,7-tetrahydro-2,5a-methano[1,4]diazepino[1,7-a]-quinoxaline-5-carboxylates of the formula (1) wherein Ar means phenyl or p-methoxyphenyl, and to a method for their synthesis. Method for synthesis of compound of the formula (1) involves interaction of 3-aroyl-5-phenylpyrrolo[1,2-a]-quinoxaline-1,2,4(5H)-triones with isopropyl-3-amino-3-(3-pyridinyl)-2-propenoate in an inert aprotonic solvent medium and the following isolation of end substances. The proposed method provides synthesis of novel compounds of the formula (1) possessing antibacterial effect with high yield and selectivity. ^ EFFECT: improved method of synthesis. ^ 4 cl, 1 tbl, 3 ex
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title ISOPROPYL-12-AROYL-2-HYDROXY-1,6-DIOXO-4-(3-PYRIDINYL)-7-PHENYL-1,3,6,7-TETRAHYDRO-2,5alpha-METHANO[1,4]DIAZEPINO[1,7alpha]-QUINOXALINE-5-CARBOXYLATES AND METHOD FOR THEIR PREPARING
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