LATARCIN PEPTIDES HAVING ANTIBACTERIAL ACTIVITY

LATARCIN PEPTIDES HAVING ANTIBACTERIAL ACTIVITY

FIELD: biochemistry, biotechnology, medicine, in particular bioactive peptides. ^ SUBSTANCE: latarcins 3a and 3b are obtained from poison of spider Lachesana tarabaevi. Said latarcins comprise of 24 amino acid residues, represent linear peptized and have no cysteine residues. Latarcins obtained by c...

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Hauptverfasser: FEOFANOV ALEKSEJ VALER'EVICH, SUROVOJ ANDREJ JUR'EVICH, VASILEVSKIJ ALEKSANDR ALEKSANDROVICH, GRISHIN EVGENIJ VASIL'EVICH, KOZLOV SERGEJ ALEKSANDROVICH, ARSEN'EV ALEKSANDR SERGEEVICH
Format: Patent
Sprache:eng ; rus
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:FIELD: biochemistry, biotechnology, medicine, in particular bioactive peptides. ^ SUBSTANCE: latarcins 3a and 3b are obtained from poison of spider Lachesana tarabaevi. Said latarcins comprise of 24 amino acid residues, represent linear peptized and have no cysteine residues. Latarcins obtained by chemical synthesis exhibit biological properties being identical to natural ones. Latarcins have antibacterial properties in relates to gram-positive and gram-negative bacteria and yeast fungi. Latarcin peptide has amino acid sequence of H2N-Ser1-Trp2-X3-Ser4-Met5-Ala6-Lys7-Lys8-Leu9-Lys10-Glu11-Tyr12-Met13-Glu14-Lys15-Leu16-Lys17-Gln18-Arg19-Ala20-NH2, wherein X - lysine Lys3 residue (latarcin 3a, LtAMP-3a) or alanine Ala3 residue (latarcin 3b, LtAMP-3b). Latarcins have high antibacterial activity, cytotoxicity in relates to certain cells and are useful in production of pharmaceutical agents. ^ EFFECT: latarcin peptides having increased antibacterial activity. ^ 6 dwg, 3 tbl, 8 ex