CRYSTALLINE STRUCTURE OF PHOSPHODIESTERASE 5 AND ITS USING

FIELD: biotechnology, biochemistry, enzymes. ^ SUBSTANCE: invention relates to crystalline structures of phosphodiesterase 5 (PDE 5) and complexes "PDE 5/ligand PDE 5", and their using for identification of PDE 5 ligands including compounds representing inhibitors of PDE 5. Also, invention...

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Hauptverfasser:	KHOPKINS EHNDRJU LI, RINGROUZ KHIZER DZHOAN, DZHENKINS TIMOTI MARK, KEHMP SARA KHELEN, GRUM KOLIN RODZHER, BRAUN DEHVID GREHKHEM, TEHJLOR VENDI EHLEJN, ROBINSON KOLIN MARK, O`GARA MARGARET MEHRI
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology, biochemistry, enzymes. ^ SUBSTANCE: invention relates to crystalline structures of phosphodiesterase 5 (PDE 5) and complexes "PDE 5/ligand PDE 5", and their using for identification of PDE 5 ligands including compounds representing inhibitors of PDE 5. Also, invention relates to methods for identifying indicated compound inhibiting activity of PDE 5. The claimed invention provides preparing a novel crystal of enzyme. ^ EFFECT: valuable properties of crystalline enzyme. ^ 24 cl, 5 dwg, 3 tbl, 15 ex