CIS-CIS-[4-NITRAMINOPYRIDIN-N]TETRACHLOROPLATINUM (IV) TRIMETHYLOLAMINOMETHANE SALT AND METHOD FOR ITS PREPARING

FIELD: chemistry of metalloorganic compounds, medicine, oncology. ^ SUBSTANCE: invention relates to a method for synthesis of physiologically active compounds, namely: cis-cis-[4-nitraminopyridin-N]tetrachloroplatinum (IV) trimethylolaminomethane salt of the formula: PtCl4 . 2Li wherein Li means com...

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Hauptverfasser:	SMIRNOV VJACHESLAV ALEKSANDROVICH, FEDOROV BORIS SERGEEVICH, FADEEV MIKHAIL ARSEN'EVICH, MEL'NIKOV MIKHAIL JAKOVLEVICH, KOZUB GALINA IVANOVNA, KONDAKOV SERGEJ EHMIL'EVICH
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	FIELD: chemistry of metalloorganic compounds, medicine, oncology. ^ SUBSTANCE: invention relates to a method for synthesis of physiologically active compounds, namely: cis-cis-[4-nitraminopyridin-N]tetrachloroplatinum (IV) trimethylolaminomethane salt of the formula: PtCl4 . 2Li wherein Li means compound of the formula: . Method involves interaction of 4-nitraminopyridine with potassium hexachloroplatinate followed by separating formed cis-bis-(4-nitramino-N)tetrachloroplatinum, its treatment with trimethylolaminomethane and isolation of the end substance. Synthesized compound can be used in medicinal practice as both a separate low-toxic anti-metastatic medicinal agent and in composition with the known preparations. ^ EFFECT: valuable medicinal properties of compound, improved method of synthesis. ^ 2 cl, 1 ex