ARIPIPRAZOLE MEDICINAL AGENT OF LOW HYGROSCOPICITY AND METHODS FOR ITS PREPARING

FIELD: pharmacy. ^ SUBSTANCE: invention relates to the improved formulation of aripiprazole showing the reduced hygroscopicity. These formulations are not converted to hydrate and not loss the initial solubility being even the medicinal preparation comprising anhydrous apipiprazole crystals are stor...

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Bibliographische Detailangaben
Hauptverfasser:	SINKHAMA KOITI, TOMINAGA MITIAKI, FUDZIMOTO KIJOSI, JABUUTI TSUJOSI, JAMADA SOKHEI, TANIGUTI JOUITI, NAKAGAVA TOMONORI, TAKAKHASI MASANORI, OI JOSIKHIRO, ISIGAMI MAKOTO, NISIOKA JOSIKHIRO, ABE KAORU, KOBAJASI NORIJUKI, BANDO TAKUDZI, KAVASAKI DZUNITI, TOMIKAVA KENDZI, FUDZIMURA TSUTOMU, AOKI SATOSI, UTSUMI NAOTO
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING
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Beschreibung
Zusammenfassung:	FIELD: pharmacy. ^ SUBSTANCE: invention relates to the improved formulation of aripiprazole showing the reduced hygroscopicity. These formulations are not converted to hydrate and not loss the initial solubility being even the medicinal preparation comprising anhydrous apipiprazole crystals are stored for a long time. Also, invention describes method for preparing these formulation and pharmaceutical composition based on thereof. ^ EFFECT: improved and valuable pharmaceutical properties of agent. ^ 22 cl, 32 dwg, 7 tbl, 28 ex