METHOD FOR PREPARING PYRIMIDINONE COMPOUND AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a method for preparing pyrimidinone compound of the formula (1) and its salts. Method involves thioamidation reaction of compound of the formula (7) with using Lavesson's reagent followed by treatment of...
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| creator | LI DZUNG-BOK TAN KHIUN-KVANG KIM DZI-KHAN JOO BIOJUNG-VUG KIM SANG-LIN |
| description | FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a method for preparing pyrimidinone compound of the formula (1) and its salts. Method involves thioamidation reaction of compound of the formula (7) with using Lavesson's reagent followed by treatment of the reaction product with alcoholic reagent as shown in the following reaction scheme 2: (7) -> (1) wherein R1 represents (C1-C4)-alkyl with linear or branched chain; R2 represents (C1-C4)-alkyl with linear or branched chain; R3 and R4 represent (C1-C4)-alkyl with linear or branched chain; n is a whole number taken among 1, 2, 3, 4, 5 and 6. Invention provides preparing pyrimidinone compound of the formula (1) by relatively simple and high-effective method. Also, invention relates to pyrimidinone trihydrate compound of the formula 91). ^ EFFECT: improved preparing method. ^ 10 cl, 2 tbl, 5 ex |
| format | Patent |
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Method involves thioamidation reaction of compound of the formula (7) with using Lavesson's reagent followed by treatment of the reaction product with alcoholic reagent as shown in the following reaction scheme 2: (7) -> (1) wherein R1 represents (C1-C4)-alkyl with linear or branched chain; R2 represents (C1-C4)-alkyl with linear or branched chain; R3 and R4 represent (C1-C4)-alkyl with linear or branched chain; n is a whole number taken among 1, 2, 3, 4, 5 and 6. Invention provides preparing pyrimidinone compound of the formula (1) by relatively simple and high-effective method. Also, invention relates to pyrimidinone trihydrate compound of the formula 91). ^ EFFECT: improved preparing method. ^ 10 cl, 2 tbl, 5 ex</description><edition>7</edition><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20051110&DB=EPODOC&CC=RU&NR=2263675C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20051110&DB=EPODOC&CC=RU&NR=2263675C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI DZUNG-BOK</creatorcontrib><creatorcontrib>TAN KHIUN-KVANG</creatorcontrib><creatorcontrib>KIM DZI-KHAN</creatorcontrib><creatorcontrib>JOO BIOJUNG-VUG</creatorcontrib><creatorcontrib>KIM SANG-LIN</creatorcontrib><title>METHOD FOR PREPARING PYRIMIDINONE COMPOUND AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS</title><description>FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a method for preparing pyrimidinone compound of the formula (1) and its salts. Method involves thioamidation reaction of compound of the formula (7) with using Lavesson's reagent followed by treatment of the reaction product with alcoholic reagent as shown in the following reaction scheme 2: (7) -> (1) wherein R1 represents (C1-C4)-alkyl with linear or branched chain; R2 represents (C1-C4)-alkyl with linear or branched chain; R3 and R4 represent (C1-C4)-alkyl with linear or branched chain; n is a whole number taken among 1, 2, 3, 4, 5 and 6. Invention provides preparing pyrimidinone compound of the formula (1) by relatively simple and high-effective method. 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Method involves thioamidation reaction of compound of the formula (7) with using Lavesson's reagent followed by treatment of the reaction product with alcoholic reagent as shown in the following reaction scheme 2: (7) -> (1) wherein R1 represents (C1-C4)-alkyl with linear or branched chain; R2 represents (C1-C4)-alkyl with linear or branched chain; R3 and R4 represent (C1-C4)-alkyl with linear or branched chain; n is a whole number taken among 1, 2, 3, 4, 5 and 6. Invention provides preparing pyrimidinone compound of the formula (1) by relatively simple and high-effective method. Also, invention relates to pyrimidinone trihydrate compound of the formula 91). ^ EFFECT: improved preparing method. ^ 10 cl, 2 tbl, 5 ex</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | METHOD FOR PREPARING PYRIMIDINONE COMPOUND AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS |
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