METHOD FOR PREPARING 1,2,5-TRIMETHYL-4-PHENYL-4-PROPIONYLOXYPIPERIDINE HYDROCHLORIDE (PROMEDOL)

FIELD: chemistry of heterocyclic compounds, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a method for preparing 1,2,5-trimethyl-4-phenyl-4-propionyloxypiperidine hydrochloride (promedol) used extensively as an analgetic medicinal agent. Method involves reaction of 1,2,5-trimethyl...

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Bibliographische Detailangaben
Hauptverfasser:	PRONIN I.M, SHMAKOV A.N, BARANOV JU.I, LUKASHOV O.I, SVETLOVA L.M
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: chemistry of heterocyclic compounds, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a method for preparing 1,2,5-trimethyl-4-phenyl-4-propionyloxypiperidine hydrochloride (promedol) used extensively as an analgetic medicinal agent. Method involves reaction of 1,2,5-trimethylpiperidone-4 with aromatic compound of alkaline or earth-alkaline metal that is carried out at temperature from -10°C to -100°C and wherein 1-1.15 mol of aromatic compound of alkaline or earth-alkaline metal, in particular, phenyllithium or phenylmagnesium bromide is used per 1 mol of 1,2,5-trimethylpiperidone-4 followed by two-fold treatment with propionyl chloride. Invention provides enhancing yield of promedol. ^ EFFECT: improved preparing method. ^ 5 cl, 8 ex