METHOD FOR PRODUCTION OF 5-CHLORO-4-[(2-IMIDAZOLINE-2-YL)AMINO]-2,1,3-BENZOTHIADIAZOLE HYDROCHLORIDE

METHOD FOR PRODUCTION OF 5-CHLORO-4-[(2-IMIDAZOLINE-2-YL)AMINO]-2,1,3-BENZOTHIADIAZOLE HYDROCHLORIDE

FIELD: organic chemistry. ^ SUBSTANCE: method relates to new method for production of 5-chloro-4-[(2-imidazoline-2-yl)amino]-2,1,3-benzothiadiazole hydrochloride of formula I . Claimed compound is high effective drug and is used in medicine as myorelaxant of central action. Claimed method includes c...

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Hauptverfasser: GLUSHKOV R.G, MODNIKOVA G.A, DRONOVA L.N, L'VOV A.I
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:FIELD: organic chemistry. ^ SUBSTANCE: method relates to new method for production of 5-chloro-4-[(2-imidazoline-2-yl)amino]-2,1,3-benzothiadiazole hydrochloride of formula I . Claimed compound is high effective drug and is used in medicine as myorelaxant of central action. Claimed method includes condensation of N,N-dimethyldichloromethyleneammonium chloride with 5-chloro-4-amino-1,1,3-benzothiadiazole in organic solvent followed by treatment of formed alpha-chloroformamidine of formula R-N=C(Cl)N(CH3)2, wherein R is 5-chloro-2,1,3-benzothiazol-4-yl, with ethylenediamine. Formed intermediate of formula R-N=C(NH-CH2-CH2-NH2)N(CH3)2 is treated with hydrochloric acid, heated in organic solvent and 5-chloro-4-[(2-imidazoline-2-yl)amino]-2,1,3-benzothiadiazole hydrochloride of formula I is isolated. ^ EFFECT: simplified method for preparation of target compound directly in hydrochloride form.