N-HETEROCYCLIC DERIVATIVES AND THEIR APPLYING AS NITROGEN OXIDE SYNTHASE INHIBITOR
FIELD: organic chemistry, biochemistry. ^ SUBSTANCE: invention relates to new N-heterocyclic derivatives of the formula (I): ^ ^ wherein A means -OR1, -C(O)N(R1)R2 or -N(R1)R21; each among X, Y and Z means independently nitrogen atom (N) or C(R19); each U means nitrogen atom (N) or C(R5) under condi...
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| creator | DEHJVI DEHVID D MAKMILLAN KIRK DOLLE ROLAND EHLLVUD III PARKINSON DZHON MORRISSI MAJKL M DEVLIN DZHEJMS DZH FILLIPS GARRI B OLMEJER MAJKL KH. DZH ZKHAO ZUCHUN BOLDVIN DZHON DZH PARADKAR VIDIADKHAR MADKHAV JE BIN EHRIKSON SHON DEHVID PAN GONGKHUA ARNAIZ DAMIAN O |
| description | FIELD: organic chemistry, biochemistry. ^ SUBSTANCE: invention relates to new N-heterocyclic derivatives of the formula (I): ^ ^ wherein A means -OR1, -C(O)N(R1)R2 or -N(R1)R21; each among X, Y and Z means independently nitrogen atom (N) or C(R19); each U means nitrogen atom (N) or C(R5) under condition that U means N only when X means N, and Z and Y mean CR19; each W means N or CH; V means: (1) N(R4); (2) C(R4)H or (3) group bound directly with group -C(R14)(R20)n-A wherein means 5-6-membered N-heterocycle optionally comprising additional heteroatom in 6-membered ring taken among oxygen, sulfur atom and NR6 wherein R6 means hydrogen atom, optionally substituted phenyl, 6-membered heterocycle comprising 1-2 nitrogen atoms optionally substituted with 5-membered heterocyclyl comprising 1-2 nitrogen atoms, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, (C1-C6)-alkoxycarbonyl, acetyl and others. ^ EFFECT: valuable biochemical properties of compounds. ^ 44 cl, 7 dwg, 7 tbl |
| format | Patent |
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DZH ; ZKHAO ZUCHUN ; BOLDVIN DZHON DZH ; PARADKAR VIDIADKHAR MADKHAV ; JE BIN ; EHRIKSON SHON DEHVID ; PAN GONGKHUA ; ARNAIZ DAMIAN O</creator><creatorcontrib>DEHJVI DEHVID D ; MAKMILLAN KIRK ; DOLLE ROLAND EHLLVUD III ; PARKINSON DZHON ; MORRISSI MAJKL M ; DEVLIN DZHEJMS DZH ; FILLIPS GARRI B ; OLMEJER MAJKL KH. DZH ; ZKHAO ZUCHUN ; BOLDVIN DZHON DZH ; PARADKAR VIDIADKHAR MADKHAV ; JE BIN ; EHRIKSON SHON DEHVID ; PAN GONGKHUA ; ARNAIZ DAMIAN O</creatorcontrib><description>FIELD: organic chemistry, biochemistry. ^ SUBSTANCE: invention relates to new N-heterocyclic derivatives of the formula (I): ^ ^ wherein A means -OR1, -C(O)N(R1)R2 or -N(R1)R21; each among X, Y and Z means independently nitrogen atom (N) or C(R19); each U means nitrogen atom (N) or C(R5) under condition that U means N only when X means N, and Z and Y mean CR19; each W means N or CH; V means: (1) N(R4); (2) C(R4)H or (3) group bound directly with group -C(R14)(R20)n-A wherein means 5-6-membered N-heterocycle optionally comprising additional heteroatom in 6-membered ring taken among oxygen, sulfur atom and NR6 wherein R6 means hydrogen atom, optionally substituted phenyl, 6-membered heterocycle comprising 1-2 nitrogen atoms optionally substituted with 5-membered heterocyclyl comprising 1-2 nitrogen atoms, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, (C1-C6)-alkoxycarbonyl, acetyl and others. ^ EFFECT: valuable biochemical properties of compounds. ^ 44 cl, 7 dwg, 7 tbl</description><edition>7</edition><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20041210&DB=EPODOC&CC=RU&NR=2241708C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20041210&DB=EPODOC&CC=RU&NR=2241708C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DEHJVI DEHVID D</creatorcontrib><creatorcontrib>MAKMILLAN KIRK</creatorcontrib><creatorcontrib>DOLLE ROLAND EHLLVUD III</creatorcontrib><creatorcontrib>PARKINSON DZHON</creatorcontrib><creatorcontrib>MORRISSI MAJKL M</creatorcontrib><creatorcontrib>DEVLIN DZHEJMS DZH</creatorcontrib><creatorcontrib>FILLIPS GARRI B</creatorcontrib><creatorcontrib>OLMEJER MAJKL KH. DZH</creatorcontrib><creatorcontrib>ZKHAO ZUCHUN</creatorcontrib><creatorcontrib>BOLDVIN DZHON DZH</creatorcontrib><creatorcontrib>PARADKAR VIDIADKHAR MADKHAV</creatorcontrib><creatorcontrib>JE BIN</creatorcontrib><creatorcontrib>EHRIKSON SHON DEHVID</creatorcontrib><creatorcontrib>PAN GONGKHUA</creatorcontrib><creatorcontrib>ARNAIZ DAMIAN O</creatorcontrib><title>N-HETEROCYCLIC DERIVATIVES AND THEIR APPLYING AS NITROGEN OXIDE SYNTHASE INHIBITOR</title><description>FIELD: organic chemistry, biochemistry. ^ SUBSTANCE: invention relates to new N-heterocyclic derivatives of the formula (I): ^ ^ wherein A means -OR1, -C(O)N(R1)R2 or -N(R1)R21; each among X, Y and Z means independently nitrogen atom (N) or C(R19); each U means nitrogen atom (N) or C(R5) under condition that U means N only when X means N, and Z and Y mean CR19; each W means N or CH; V means: (1) N(R4); (2) C(R4)H or (3) group bound directly with group -C(R14)(R20)n-A wherein means 5-6-membered N-heterocycle optionally comprising additional heteroatom in 6-membered ring taken among oxygen, sulfur atom and NR6 wherein R6 means hydrogen atom, optionally substituted phenyl, 6-membered heterocycle comprising 1-2 nitrogen atoms optionally substituted with 5-membered heterocyclyl comprising 1-2 nitrogen atoms, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, (C1-C6)-alkoxycarbonyl, acetyl and others. ^ EFFECT: valuable biochemical properties of compounds. ^ 44 cl, 7 dwg, 7 tbl</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQANAsDqL-w_1AQauga0zO5qBcyuUsZipF4iRaqP-Pix_g9Ja3NMJVQEWJLruWHHgU6q1Sjwkse9CAJGC7rs3EDdgETCqxQYZ4I4-QMmuwCYE40Jk0ytosHuNzLpufKwMXVBeqMr2HMk_jvbzKZ5BrXR92x-3J1fs_yheVvi-X</recordid><startdate>20041210</startdate><enddate>20041210</enddate><creator>DEHJVI DEHVID D</creator><creator>MAKMILLAN KIRK</creator><creator>DOLLE ROLAND EHLLVUD III</creator><creator>PARKINSON DZHON</creator><creator>MORRISSI MAJKL M</creator><creator>DEVLIN DZHEJMS DZH</creator><creator>FILLIPS GARRI B</creator><creator>OLMEJER MAJKL KH. 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DZH</creatorcontrib><creatorcontrib>ZKHAO ZUCHUN</creatorcontrib><creatorcontrib>BOLDVIN DZHON DZH</creatorcontrib><creatorcontrib>PARADKAR VIDIADKHAR MADKHAV</creatorcontrib><creatorcontrib>JE BIN</creatorcontrib><creatorcontrib>EHRIKSON SHON DEHVID</creatorcontrib><creatorcontrib>PAN GONGKHUA</creatorcontrib><creatorcontrib>ARNAIZ DAMIAN O</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DEHJVI DEHVID D</au><au>MAKMILLAN KIRK</au><au>DOLLE ROLAND EHLLVUD III</au><au>PARKINSON DZHON</au><au>MORRISSI MAJKL M</au><au>DEVLIN DZHEJMS DZH</au><au>FILLIPS GARRI B</au><au>OLMEJER MAJKL KH. DZH</au><au>ZKHAO ZUCHUN</au><au>BOLDVIN DZHON DZH</au><au>PARADKAR VIDIADKHAR MADKHAV</au><au>JE BIN</au><au>EHRIKSON SHON DEHVID</au><au>PAN GONGKHUA</au><au>ARNAIZ DAMIAN O</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>N-HETEROCYCLIC DERIVATIVES AND THEIR APPLYING AS NITROGEN OXIDE SYNTHASE INHIBITOR</title><date>2004-12-10</date><risdate>2004</risdate><abstract>FIELD: organic chemistry, biochemistry. ^ SUBSTANCE: invention relates to new N-heterocyclic derivatives of the formula (I): ^ ^ wherein A means -OR1, -C(O)N(R1)R2 or -N(R1)R21; each among X, Y and Z means independently nitrogen atom (N) or C(R19); each U means nitrogen atom (N) or C(R5) under condition that U means N only when X means N, and Z and Y mean CR19; each W means N or CH; V means: (1) N(R4); (2) C(R4)H or (3) group bound directly with group -C(R14)(R20)n-A wherein means 5-6-membered N-heterocycle optionally comprising additional heteroatom in 6-membered ring taken among oxygen, sulfur atom and NR6 wherein R6 means hydrogen atom, optionally substituted phenyl, 6-membered heterocycle comprising 1-2 nitrogen atoms optionally substituted with 5-membered heterocyclyl comprising 1-2 nitrogen atoms, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, (C1-C6)-alkoxycarbonyl, acetyl and others. ^ EFFECT: valuable biochemical properties of compounds. ^ 44 cl, 7 dwg, 7 tbl</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| title | N-HETEROCYCLIC DERIVATIVES AND THEIR APPLYING AS NITROGEN OXIDE SYNTHASE INHIBITOR |
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