FUSED PROTEIN ELICITING IN VIVO ENHANCED ACTIVITY OF ERYTHROPOIETIN
FIELD: molecular biology, genetic and protein engineering. SUBSTANCE: invention relates to the fused protein eliciting in vivo the enhanced activity of erythropoietin. In the fused protein peptide fragment from carboxy-end of thrombopoietin amino acids 337-353 is fused with carboxy-end of human eryt...
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| creator | KIM KI-VAN OKH MIUNG-SUK PARK DZI-SOOK CHUNG BO-SUP LI DONG-EOK |
| description | FIELD: molecular biology, genetic and protein engineering. SUBSTANCE: invention relates to the fused protein eliciting in vivo the enhanced activity of erythropoietin. In the fused protein peptide fragment from carboxy-end of thrombopoietin amino acids 337-353 is fused with carboxy-end of human erythropoietin. Invention involves also nucleic acid encoding the fused protein and method for it preparing. The advantage of invention involves that the fused protein shows the significantly increased index half-life in vivo due to the enhanced level of carbohydrates being without loss of its activity that is typical for erythropoietin and it causes neither antigenicity in its application in human body. EFFECT: valuable medicinal properties of protein. 5 cl, 5 dwg, 6 ex |
| format | Patent |
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SUBSTANCE: invention relates to the fused protein eliciting in vivo the enhanced activity of erythropoietin. In the fused protein peptide fragment from carboxy-end of thrombopoietin amino acids 337-353 is fused with carboxy-end of human erythropoietin. Invention involves also nucleic acid encoding the fused protein and method for it preparing. The advantage of invention involves that the fused protein shows the significantly increased index half-life in vivo due to the enhanced level of carbohydrates being without loss of its activity that is typical for erythropoietin and it causes neither antigenicity in its application in human body. 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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | FUSED PROTEIN ELICITING IN VIVO ENHANCED ACTIVITY OF ERYTHROPOIETIN |
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