OPTICALLY ACTIVE DERIVATIVES OF BENZOPYRANE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF ESTROGEN-SENSITIVE DISEASES
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new optically active derivatives of benzopyrane of the formula: wherein R1 and R2 are taken independently among group consisting of hydroxyl and radical that can be transformed to hydroxyl in vivo, such as acyloxy-group, -...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | LJABRI FERNAN GOT'E SIL'VAN MERAN IV |
| description | FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new optically active derivatives of benzopyrane of the formula: wherein R1 and R2 are taken independently among group consisting of hydroxyl and radical that can be transformed to hydroxyl in vivo, such as acyloxy-group, -OR4,-OC(O)R7 or -OC(O)OR4 (wherein R4 represents alkyl, alkenyl, alkynyl or aryl; and R7 represents amino-, alkylamino-group, aminoalkyl and alkylsulfanyl); and R3 represents -CH2- or -CH2CH2-; or its pharmaceutically acceptable salt wherein indicated compound or salt are optically active since they comprise above 50% (by mass relatively all stereoisomers) of 2S stereoisomers. These compounds elicit inhibitory activity with respect to sexual steroid and can be used in treatment of estrogen-sensitive diseases, such as mammary gland cancer and endometrial cancer. Prepared stereoisomers show good stability in storage and bioavailability as compared with their racemic mixtures. EFFECT: improved treatment method, valuable medicinal properties of compounds. 17 cl, 5 dwg, 3 tbl, 23 ex |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_RU2220143C2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>RU2220143C2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_RU2220143C23</originalsourceid><addsrcrecordid>eNqNjUEOgjAQRdm4MOod5gCSKHiBoR2kCXRIO5DghhBTV0ZJ8CAeWTAewNV_i__-X0dvrsUoLMsOUIlpCTQ50-KCHjiHjOyF686hpT3UBboKFTVfBxRXNXsjhi1k6EnDDFKQo1lEq6EiKVhDzg7EEUpFVpZR8uL4TDb2ZBd_uTWe5gm_jVa34T6F3S83EeQkqojD-OzDNA7X8Aiv3jVJkhyOp1Ql6R-VDx6tQKk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>OPTICALLY ACTIVE DERIVATIVES OF BENZOPYRANE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF ESTROGEN-SENSITIVE DISEASES</title><source>esp@cenet</source><creator>LJABRI FERNAN ; GOT'E SIL'VAN ; MERAN IV</creator><creatorcontrib>LJABRI FERNAN ; GOT'E SIL'VAN ; MERAN IV</creatorcontrib><description>FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new optically active derivatives of benzopyrane of the formula: wherein R1 and R2 are taken independently among group consisting of hydroxyl and radical that can be transformed to hydroxyl in vivo, such as acyloxy-group, -OR4,-OC(O)R7 or -OC(O)OR4 (wherein R4 represents alkyl, alkenyl, alkynyl or aryl; and R7 represents amino-, alkylamino-group, aminoalkyl and alkylsulfanyl); and R3 represents -CH2- or -CH2CH2-; or its pharmaceutically acceptable salt wherein indicated compound or salt are optically active since they comprise above 50% (by mass relatively all stereoisomers) of 2S stereoisomers. These compounds elicit inhibitory activity with respect to sexual steroid and can be used in treatment of estrogen-sensitive diseases, such as mammary gland cancer and endometrial cancer. Prepared stereoisomers show good stability in storage and bioavailability as compared with their racemic mixtures. EFFECT: improved treatment method, valuable medicinal properties of compounds. 17 cl, 5 dwg, 3 tbl, 23 ex</description><edition>7</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; STEROIDS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031227&DB=EPODOC&CC=RU&NR=2220143C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031227&DB=EPODOC&CC=RU&NR=2220143C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LJABRI FERNAN</creatorcontrib><creatorcontrib>GOT'E SIL'VAN</creatorcontrib><creatorcontrib>MERAN IV</creatorcontrib><title>OPTICALLY ACTIVE DERIVATIVES OF BENZOPYRANE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF ESTROGEN-SENSITIVE DISEASES</title><description>FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new optically active derivatives of benzopyrane of the formula: wherein R1 and R2 are taken independently among group consisting of hydroxyl and radical that can be transformed to hydroxyl in vivo, such as acyloxy-group, -OR4,-OC(O)R7 or -OC(O)OR4 (wherein R4 represents alkyl, alkenyl, alkynyl or aryl; and R7 represents amino-, alkylamino-group, aminoalkyl and alkylsulfanyl); and R3 represents -CH2- or -CH2CH2-; or its pharmaceutically acceptable salt wherein indicated compound or salt are optically active since they comprise above 50% (by mass relatively all stereoisomers) of 2S stereoisomers. These compounds elicit inhibitory activity with respect to sexual steroid and can be used in treatment of estrogen-sensitive diseases, such as mammary gland cancer and endometrial cancer. Prepared stereoisomers show good stability in storage and bioavailability as compared with their racemic mixtures. EFFECT: improved treatment method, valuable medicinal properties of compounds. 17 cl, 5 dwg, 3 tbl, 23 ex</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjUEOgjAQRdm4MOod5gCSKHiBoR2kCXRIO5DghhBTV0ZJ8CAeWTAewNV_i__-X0dvrsUoLMsOUIlpCTQ50-KCHjiHjOyF686hpT3UBboKFTVfBxRXNXsjhi1k6EnDDFKQo1lEq6EiKVhDzg7EEUpFVpZR8uL4TDb2ZBd_uTWe5gm_jVa34T6F3S83EeQkqojD-OzDNA7X8Aiv3jVJkhyOp1Ql6R-VDx6tQKk</recordid><startdate>20031227</startdate><enddate>20031227</enddate><creator>LJABRI FERNAN</creator><creator>GOT'E SIL'VAN</creator><creator>MERAN IV</creator><scope>EVB</scope></search><sort><creationdate>20031227</creationdate><title>OPTICALLY ACTIVE DERIVATIVES OF BENZOPYRANE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF ESTROGEN-SENSITIVE DISEASES</title><author>LJABRI FERNAN ; GOT'E SIL'VAN ; MERAN IV</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2220143C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2003</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>LJABRI FERNAN</creatorcontrib><creatorcontrib>GOT'E SIL'VAN</creatorcontrib><creatorcontrib>MERAN IV</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LJABRI FERNAN</au><au>GOT'E SIL'VAN</au><au>MERAN IV</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>OPTICALLY ACTIVE DERIVATIVES OF BENZOPYRANE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF ESTROGEN-SENSITIVE DISEASES</title><date>2003-12-27</date><risdate>2003</risdate><abstract>FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new optically active derivatives of benzopyrane of the formula: wherein R1 and R2 are taken independently among group consisting of hydroxyl and radical that can be transformed to hydroxyl in vivo, such as acyloxy-group, -OR4,-OC(O)R7 or -OC(O)OR4 (wherein R4 represents alkyl, alkenyl, alkynyl or aryl; and R7 represents amino-, alkylamino-group, aminoalkyl and alkylsulfanyl); and R3 represents -CH2- or -CH2CH2-; or its pharmaceutically acceptable salt wherein indicated compound or salt are optically active since they comprise above 50% (by mass relatively all stereoisomers) of 2S stereoisomers. These compounds elicit inhibitory activity with respect to sexual steroid and can be used in treatment of estrogen-sensitive diseases, such as mammary gland cancer and endometrial cancer. Prepared stereoisomers show good stability in storage and bioavailability as compared with their racemic mixtures. EFFECT: improved treatment method, valuable medicinal properties of compounds. 17 cl, 5 dwg, 3 tbl, 23 ex</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_RU2220143C2 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS |
| title | OPTICALLY ACTIVE DERIVATIVES OF BENZOPYRANE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF ESTROGEN-SENSITIVE DISEASES |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T02%3A07%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LJABRI%20FERNAN&rft.date=2003-12-27&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ERU2220143C2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |