INHIBITORS OF ENZYMES CONVERTING 1beta-INTERLEUKIN
FIELD: organic chemistry, biochemistry, medicine. SUBSTANCE: invention relates to compounds of the general formulas alpha- and beta-: and , wherein n = 0, 1 or 2; m and m' represent 1 or 2; R11 means: or ; R2' = R2 is hydrogen atom; R3 is -CH2Ar or 5-15-membered nonaromatic monocyclic grou...
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| creator | GOLEK DZHULIAN M.S LIVINGSTON DEHVID DZH DAFFI DZHON P MERKO MARK A ZELLE ROBERT E BEMIZ GAJ V FRIDMAN VOL'F GERMAN MALLIKAN MAJKL D |
| description | FIELD: organic chemistry, biochemistry, medicine. SUBSTANCE: invention relates to compounds of the general formulas alpha- and beta-: and , wherein n = 0, 1 or 2; m and m' represent 1 or 2; R11 means: or ; R2' = R2 is hydrogen atom; R3 is -CH2Ar or 5-15-membered nonaromatic monocyclic group that can comprise from 0 to 2 endocyclic nitrogen atoms; R4 is unbranched (C1-5)-alkyl group; R5 is taken among group including -C(0)R7, -C(0)OR9, -C(0)C(0)R7; R7 is taken among the group: phenyl, naphthyl, isoquinoline being phenyl can be substituted with halogen atom, (C1-6)-alkoxy group, 1,2-methylenedioxy-group or N(H)C(O)-(C1-6)-alkyl; R9 is taken independently among direct -alkyl group optionally substituted with phenyl; R12 and R13 are taken independently among the group including R7, -C(O)-R7 and C(O)-N(H)-R7; or R12 and R13 form in common 4-8-membered saturated cyclic group. Invention relates to pharmaceutical composition used for inhibition of activity of enzyme converting 1beta-interleukin (ICE), to method for inhibition of activity of ICE, to methods for treatment or prophylaxis of IL-mediated diseases. EFFECT: valuable medicinal properties of compounds. 14 cl, 1 tbl |
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SUBSTANCE: invention relates to compounds of the general formulas alpha- and beta-: and , wherein n = 0, 1 or 2; m and m' represent 1 or 2; R11 means: or ; R2' = R2 is hydrogen atom; R3 is -CH2Ar or 5-15-membered nonaromatic monocyclic group that can comprise from 0 to 2 endocyclic nitrogen atoms; R4 is unbranched (C1-5)-alkyl group; R5 is taken among group including -C(0)R7, -C(0)OR9, -C(0)C(0)R7; R7 is taken among the group: phenyl, naphthyl, isoquinoline being phenyl can be substituted with halogen atom, (C1-6)-alkoxy group, 1,2-methylenedioxy-group or N(H)C(O)-(C1-6)-alkyl; R9 is taken independently among direct -alkyl group optionally substituted with phenyl; R12 and R13 are taken independently among the group including R7, -C(O)-R7 and C(O)-N(H)-R7; or R12 and R13 form in common 4-8-membered saturated cyclic group. Invention relates to pharmaceutical composition used for inhibition of activity of enzyme converting 1beta-interleukin (ICE), to method for inhibition of activity of ICE, to methods for treatment or prophylaxis of IL-mediated diseases. EFFECT: valuable medicinal properties of compounds. 14 cl, 1 tbl</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030927&DB=EPODOC&CC=RU&NR=2213096C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030927&DB=EPODOC&CC=RU&NR=2213096C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GOLEK DZHULIAN M.S</creatorcontrib><creatorcontrib>LIVINGSTON DEHVID DZH</creatorcontrib><creatorcontrib>DAFFI DZHON P</creatorcontrib><creatorcontrib>MERKO MARK A</creatorcontrib><creatorcontrib>ZELLE ROBERT E</creatorcontrib><creatorcontrib>BEMIZ GAJ V</creatorcontrib><creatorcontrib>FRIDMAN VOL'F GERMAN</creatorcontrib><creatorcontrib>MALLIKAN MAJKL D</creatorcontrib><title>INHIBITORS OF ENZYMES CONVERTING 1beta-INTERLEUKIN</title><description>FIELD: organic chemistry, biochemistry, medicine. SUBSTANCE: invention relates to compounds of the general formulas alpha- and beta-: and , wherein n = 0, 1 or 2; m and m' represent 1 or 2; R11 means: or ; R2' = R2 is hydrogen atom; R3 is -CH2Ar or 5-15-membered nonaromatic monocyclic group that can comprise from 0 to 2 endocyclic nitrogen atoms; R4 is unbranched (C1-5)-alkyl group; R5 is taken among group including -C(0)R7, -C(0)OR9, -C(0)C(0)R7; R7 is taken among the group: phenyl, naphthyl, isoquinoline being phenyl can be substituted with halogen atom, (C1-6)-alkoxy group, 1,2-methylenedioxy-group or N(H)C(O)-(C1-6)-alkyl; R9 is taken independently among direct -alkyl group optionally substituted with phenyl; R12 and R13 are taken independently among the group including R7, -C(O)-R7 and C(O)-N(H)-R7; or R12 and R13 form in common 4-8-membered saturated cyclic group. Invention relates to pharmaceutical composition used for inhibition of activity of enzyme converting 1beta-interleukin (ICE), to method for inhibition of activity of ICE, to methods for treatment or prophylaxis of IL-mediated diseases. EFFECT: valuable medicinal properties of compounds. 14 cl, 1 tbl</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDy9PPwdPIM8Q8KVvB3U3D1i4r0dQ1WcPb3C3MNCvH0c1cwTEotSdT19AtxDfJxDfX29ONhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfFBoUZGhsYGlmbORsZEKAEAg24nVw</recordid><startdate>20030927</startdate><enddate>20030927</enddate><creator>GOLEK DZHULIAN M.S</creator><creator>LIVINGSTON DEHVID DZH</creator><creator>DAFFI DZHON P</creator><creator>MERKO MARK A</creator><creator>ZELLE ROBERT E</creator><creator>BEMIZ GAJ V</creator><creator>FRIDMAN VOL'F GERMAN</creator><creator>MALLIKAN MAJKL D</creator><scope>EVB</scope></search><sort><creationdate>20030927</creationdate><title>INHIBITORS OF ENZYMES CONVERTING 1beta-INTERLEUKIN</title><author>GOLEK DZHULIAN M.S ; LIVINGSTON DEHVID DZH ; DAFFI DZHON P ; MERKO MARK A ; ZELLE ROBERT E ; BEMIZ GAJ V ; FRIDMAN VOL'F GERMAN ; MALLIKAN MAJKL D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2213096C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2003</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GOLEK DZHULIAN M.S</creatorcontrib><creatorcontrib>LIVINGSTON DEHVID DZH</creatorcontrib><creatorcontrib>DAFFI DZHON P</creatorcontrib><creatorcontrib>MERKO MARK A</creatorcontrib><creatorcontrib>ZELLE ROBERT E</creatorcontrib><creatorcontrib>BEMIZ GAJ V</creatorcontrib><creatorcontrib>FRIDMAN VOL'F GERMAN</creatorcontrib><creatorcontrib>MALLIKAN MAJKL D</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GOLEK DZHULIAN M.S</au><au>LIVINGSTON DEHVID DZH</au><au>DAFFI DZHON P</au><au>MERKO MARK A</au><au>ZELLE ROBERT E</au><au>BEMIZ GAJ V</au><au>FRIDMAN VOL'F GERMAN</au><au>MALLIKAN MAJKL D</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBITORS OF ENZYMES CONVERTING 1beta-INTERLEUKIN</title><date>2003-09-27</date><risdate>2003</risdate><abstract>FIELD: organic chemistry, biochemistry, medicine. SUBSTANCE: invention relates to compounds of the general formulas alpha- and beta-: and , wherein n = 0, 1 or 2; m and m' represent 1 or 2; R11 means: or ; R2' = R2 is hydrogen atom; R3 is -CH2Ar or 5-15-membered nonaromatic monocyclic group that can comprise from 0 to 2 endocyclic nitrogen atoms; R4 is unbranched (C1-5)-alkyl group; R5 is taken among group including -C(0)R7, -C(0)OR9, -C(0)C(0)R7; R7 is taken among the group: phenyl, naphthyl, isoquinoline being phenyl can be substituted with halogen atom, (C1-6)-alkoxy group, 1,2-methylenedioxy-group or N(H)C(O)-(C1-6)-alkyl; R9 is taken independently among direct -alkyl group optionally substituted with phenyl; R12 and R13 are taken independently among the group including R7, -C(O)-R7 and C(O)-N(H)-R7; or R12 and R13 form in common 4-8-membered saturated cyclic group. Invention relates to pharmaceutical composition used for inhibition of activity of enzyme converting 1beta-interleukin (ICE), to method for inhibition of activity of ICE, to methods for treatment or prophylaxis of IL-mediated diseases. EFFECT: valuable medicinal properties of compounds. 14 cl, 1 tbl</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | INHIBITORS OF ENZYMES CONVERTING 1beta-INTERLEUKIN |
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