DERIVATIVES OF DOLASTATIN-15
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of dolastatin-15 of the general formula (I): A-B-D-E-F-(G)r-(K)s-L where A, B, D, E, F, G and K mean residues of alpha-amino acids; s and r each means independently 0 or 1; L means monovalent radical, for examp...
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| creator | BARLOTSTSARI TEREZA TSIRKE TOMAS KLING ANDREAS KHAUPT ANDREAS JANSSEN BERND |
| description | FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of dolastatin-15 of the general formula (I): A-B-D-E-F-(G)r-(K)s-L where A, B, D, E, F, G and K mean residues of alpha-amino acids; s and r each means independently 0 or 1; L means monovalent radical, for example, amino-group, N-substituted amino-group, beta-hydroxylamino-group, hydrazido-group, alkoxy-group, thioalkoxy-group, aminooxy-group or oximato-group. Except for, invention involves method of cancer treatment in mammal, for example, in humans that includes administration to mammal the effective amount of compound of the formula (I). EFFECT: valuable medicinal properties of derivatives. 39 cl, 3 tbl |
| format | Patent |
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SUBSTANCE: invention relates to derivatives of dolastatin-15 of the general formula (I): A-B-D-E-F-(G)r-(K)s-L where A, B, D, E, F, G and K mean residues of alpha-amino acids; s and r each means independently 0 or 1; L means monovalent radical, for example, amino-group, N-substituted amino-group, beta-hydroxylamino-group, hydrazido-group, alkoxy-group, thioalkoxy-group, aminooxy-group or oximato-group. Except for, invention involves method of cancer treatment in mammal, for example, in humans that includes administration to mammal the effective amount of compound of the formula (I). 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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | DERIVATIVES OF DOLASTATIN-15 |
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