STRAIN OF INFLUENZA VIRUS A/47/NEW CALEDONIA/99/156 (H1N1) FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR CHILDREN
medicine, pediatry, virology, vaccines. SUBSTANCE: vaccine strain A/47/New Caledonia /99/156 (H1N1) is a reassortant obtained by crossing epidemic virus A/New Caledonia/20/99 (H1N1) with virus A/Leningrad/134/47/57 (H2N2) as attenuation donor that is harmless for children and its properties ensure a...
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| creator | RUDENKO L.G ALEKSANDROVA G.I KLIMOV A.I KISELEVA I.V |
| description | medicine, pediatry, virology, vaccines. SUBSTANCE: vaccine strain A/47/New Caledonia /99/156 (H1N1) is a reassortant obtained by crossing epidemic virus A/New Caledonia/20/99 (H1N1) with virus A/Leningrad/134/47/57 (H2N2) as attenuation donor that is harmless for children and its properties ensure a possibility to obtain guaranteed reassortant vaccine strains from newly appearing epidemic viruses. The strain A/47/New Caledonia/99/156 (H1N1) multiplies actively in developing chicken embryos at optimal temperature 33-34 C and shows temperature-sensitivity and cold-adaptation. Reassortant inherited from epidemic virus two genes encoding surface proteins (hemagglutinin and neuraminidase) and six genes encoding nonglycosylated proteins from attenuation donor. The strain A/47/New Caledonia/99/156 (H1N1) is areactogenic for children in age 3-14 years in intranasal route of its administration. Thus, vaccine strain A/47/New Caledonia/99/156 (H1N1) corresponds to biological properties and indices of reactivity to requirements imposing by Pharmacopoeia article 42-3353-97 for live influenza vaccine for intranasal administration in children of age 3-14 years. EFFECT: improved method of preparing, valuable properties. 1 tbl, 1 ex |
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SUBSTANCE: vaccine strain A/47/New Caledonia /99/156 (H1N1) is a reassortant obtained by crossing epidemic virus A/New Caledonia/20/99 (H1N1) with virus A/Leningrad/134/47/57 (H2N2) as attenuation donor that is harmless for children and its properties ensure a possibility to obtain guaranteed reassortant vaccine strains from newly appearing epidemic viruses. The strain A/47/New Caledonia/99/156 (H1N1) multiplies actively in developing chicken embryos at optimal temperature 33-34 C and shows temperature-sensitivity and cold-adaptation. Reassortant inherited from epidemic virus two genes encoding surface proteins (hemagglutinin and neuraminidase) and six genes encoding nonglycosylated proteins from attenuation donor. The strain A/47/New Caledonia/99/156 (H1N1) is areactogenic for children in age 3-14 years in intranasal route of its administration. Thus, vaccine strain A/47/New Caledonia/99/156 (H1N1) corresponds to biological properties and indices of reactivity to requirements imposing by Pharmacopoeia article 42-3353-97 for live influenza vaccine for intranasal administration in children of age 3-14 years. 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SUBSTANCE: vaccine strain A/47/New Caledonia /99/156 (H1N1) is a reassortant obtained by crossing epidemic virus A/New Caledonia/20/99 (H1N1) with virus A/Leningrad/134/47/57 (H2N2) as attenuation donor that is harmless for children and its properties ensure a possibility to obtain guaranteed reassortant vaccine strains from newly appearing epidemic viruses. The strain A/47/New Caledonia/99/156 (H1N1) multiplies actively in developing chicken embryos at optimal temperature 33-34 C and shows temperature-sensitivity and cold-adaptation. Reassortant inherited from epidemic virus two genes encoding surface proteins (hemagglutinin and neuraminidase) and six genes encoding nonglycosylated proteins from attenuation donor. The strain A/47/New Caledonia/99/156 (H1N1) is areactogenic for children in age 3-14 years in intranasal route of its administration. Thus, vaccine strain A/47/New Caledonia/99/156 (H1N1) corresponds to biological properties and indices of reactivity to requirements imposing by Pharmacopoeia article 42-3353-97 for live influenza vaccine for intranasal administration in children of age 3-14 years. 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SUBSTANCE: vaccine strain A/47/New Caledonia /99/156 (H1N1) is a reassortant obtained by crossing epidemic virus A/New Caledonia/20/99 (H1N1) with virus A/Leningrad/134/47/57 (H2N2) as attenuation donor that is harmless for children and its properties ensure a possibility to obtain guaranteed reassortant vaccine strains from newly appearing epidemic viruses. The strain A/47/New Caledonia/99/156 (H1N1) multiplies actively in developing chicken embryos at optimal temperature 33-34 C and shows temperature-sensitivity and cold-adaptation. Reassortant inherited from epidemic virus two genes encoding surface proteins (hemagglutinin and neuraminidase) and six genes encoding nonglycosylated proteins from attenuation donor. The strain A/47/New Caledonia/99/156 (H1N1) is areactogenic for children in age 3-14 years in intranasal route of its administration. Thus, vaccine strain A/47/New Caledonia/99/156 (H1N1) corresponds to biological properties and indices of reactivity to requirements imposing by Pharmacopoeia article 42-3353-97 for live influenza vaccine for intranasal administration in children of age 3-14 years. EFFECT: improved method of preparing, valuable properties. 1 tbl, 1 ex</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | STRAIN OF INFLUENZA VIRUS A/47/NEW CALEDONIA/99/156 (H1N1) FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR CHILDREN |
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