ANTAGONISTS OF LUTEINIZING HORMONE RELEASING-FACTOR (VARIANTS), METHOD OF THEIR SYNTHESIS (VARIANTS), PHARMACEUTICAL COMPOSITION AND METHOD OF MEDICINAL PREPARATIONS PREPARING
medicine, hormones, peptides. SUBSTANCE: invention relates to novel antagonists of luteinizing hormone releasing factor, first of all, to peptidomimetics and peptides with modified side-chain of the formula (V): R1,R2,R3,R4,R5,R6,R7 where D -Xxx, R8 and are characterized in the invention claim and t...
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| creator | KUCHER BERNGARD BERND MIKHAEHL SHARPENT'E PARISIL-MARI BEKERS TOMAS EHMIG PETER-PAUL KLENNER TOMAS |
| description | medicine, hormones, peptides. SUBSTANCE: invention relates to novel antagonists of luteinizing hormone releasing factor, first of all, to peptidomimetics and peptides with modified side-chain of the formula (V): R1,R2,R3,R4,R5,R6,R7 where D -Xxx, R8 and are characterized in the invention claim and their salts with pharmaceutically acceptable carrier. Invention describes also therapeutic use of these compounds as analog of luteinizing hormone releasing factor showing high antagonistic activity and without nonfavorable adverse effects, especially, they do not stimulate edemas. Invention describes also method of synthesis of compound of the formula (V) by solid-phase method or partially solid-phase method and preparing therapeutic composition showing high affinity to receptors of luteinizing hormone releasing factor that involves compounds by p. p. 1-4 as an active substance. Invention describes also method of preparing medicinal preparations containing compounds by p. p. 1-9 where these compounds are mixed with accessory substances. EFFECT: new antagonists indicated above, improved method of synthesis and preparing. 17 cl, 7 tbl, 6 dwg, 3 sch, 85 ex |
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SUBSTANCE: invention relates to novel antagonists of luteinizing hormone releasing factor, first of all, to peptidomimetics and peptides with modified side-chain of the formula (V): R1,R2,R3,R4,R5,R6,R7 where D -Xxx, R8 and are characterized in the invention claim and their salts with pharmaceutically acceptable carrier. Invention describes also therapeutic use of these compounds as analog of luteinizing hormone releasing factor showing high antagonistic activity and without nonfavorable adverse effects, especially, they do not stimulate edemas. Invention describes also method of synthesis of compound of the formula (V) by solid-phase method or partially solid-phase method and preparing therapeutic composition showing high affinity to receptors of luteinizing hormone releasing factor that involves compounds by p. p. 1-4 as an active substance. Invention describes also method of preparing medicinal preparations containing compounds by p. p. 1-9 where these compounds are mixed with accessory substances. 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SUBSTANCE: invention relates to novel antagonists of luteinizing hormone releasing factor, first of all, to peptidomimetics and peptides with modified side-chain of the formula (V): R1,R2,R3,R4,R5,R6,R7 where D -Xxx, R8 and are characterized in the invention claim and their salts with pharmaceutically acceptable carrier. Invention describes also therapeutic use of these compounds as analog of luteinizing hormone releasing factor showing high antagonistic activity and without nonfavorable adverse effects, especially, they do not stimulate edemas. Invention describes also method of synthesis of compound of the formula (V) by solid-phase method or partially solid-phase method and preparing therapeutic composition showing high affinity to receptors of luteinizing hormone releasing factor that involves compounds by p. p. 1-4 as an active substance. Invention describes also method of preparing medicinal preparations containing compounds by p. p. 1-9 where these compounds are mixed with accessory substances. 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SUBSTANCE: invention relates to novel antagonists of luteinizing hormone releasing factor, first of all, to peptidomimetics and peptides with modified side-chain of the formula (V): R1,R2,R3,R4,R5,R6,R7 where D -Xxx, R8 and are characterized in the invention claim and their salts with pharmaceutically acceptable carrier. Invention describes also therapeutic use of these compounds as analog of luteinizing hormone releasing factor showing high antagonistic activity and without nonfavorable adverse effects, especially, they do not stimulate edemas. Invention describes also method of synthesis of compound of the formula (V) by solid-phase method or partially solid-phase method and preparing therapeutic composition showing high affinity to receptors of luteinizing hormone releasing factor that involves compounds by p. p. 1-4 as an active substance. Invention describes also method of preparing medicinal preparations containing compounds by p. p. 1-9 where these compounds are mixed with accessory substances. EFFECT: new antagonists indicated above, improved method of synthesis and preparing. 17 cl, 7 tbl, 6 dwg, 3 sch, 85 ex</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANTAGONISTS OF LUTEINIZING HORMONE RELEASING-FACTOR (VARIANTS), METHOD OF THEIR SYNTHESIS (VARIANTS), PHARMACEUTICAL COMPOSITION AND METHOD OF MEDICINAL PREPARATIONS PREPARING |
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