N-(3-BENZOFURANYL)UREA DERIVATIVES, MIXTURE OF THEIR ISOMERS OR INDIVIDUAL ISOMERS AND THEIR SALTS

organic synthesis. SUBSTANCE: invention provides novel derivatives of N-(3-benzofuranyl)urea having general formula I: (I), where A and D, identical or different, denote hydrogen, linear or branched C1-C6-acyl, linear or branched alkoxycarbonyl with 1-6 carbon atoms in its alkoxy moiety, halogen, OR4 group, wherein R4 is hydrogen, linear or branched C1-C8-alkyl, alkoxycarbonyl with 1-6 carbon atoms in its alkoxy moiety, benzyl, group, wherein R5 is , linear or branched C1-C4-alkyl, or group , wherein R6 is phenyl; L is oxygen or sulfur atom; R1 and R2, identical or different, denote hydrogen, cycloalkyl with up to 6 carbon atoms, linear or branched C1-C8-alkyl, C1-C8-alkoxycarbonyl, C2-C8-alkenyl, or benzoyl, or yet R1 and R2 in common with nitrogen atom form 5-7-membered saturated heterocycle; R3 is phenyl optionally substituted by 1 to 3 identical or different substituents from group including halogen, nitro, C1-C8-alkyl or C1-C8-alkoxy; in the form of isomer mixtures or individual isomers or their salts. Compounds I are biologically active. In particular, they inhibit lipoxygenase and can be useful in treatment of acute or chronic inflammatory conditions. EFFECT: extended choice of antiinflammatory agents. 14 cl, 11 tbl, 21 ex