SUBSTITUTED BENZAMIDINE DERIVATIVES

medicine. SUBSTANCE: described are substituted benzamidine derivatives of general formula I: wherein A is O-CmH2m-X1 or group of formula IV: ; m is 2-6; X1 is group formula: ; X3 is O-CnH2n-; X2 is -CnH2n-O-;; n is 1 or 2; R1 is OH, COR7 or COOR7;; R2 is (C1-C6) alkyl, -CR5R6 aryl or hydrogen (is A...

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Hauptverfasser:	EHRNST-OTTO RENT, FRANTS BIRKE, RAL'F ANDERSKEVITTS, KURT SHROMM, ARMIN FJUGNER, KRISTOFER MID, KHUBERT KHOJER
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	EHRNST-OTTO RENT FRANTS BIRKE RAL'F ANDERSKEVITTS KURT SHROMM ARMIN FJUGNER KRISTOFER MID KHUBERT KHOJER
description	medicine. SUBSTANCE: described are substituted benzamidine derivatives of general formula I: wherein A is O-CmH2m-X1 or group of formula IV: ; m is 2-6; X1 is group formula: ; X3 is O-CnH2n-; X2 is -CnH2n-O-;; n is 1 or 2; R1 is OH, COR7 or COOR7;; R2 is (C1-C6) alkyl, -CR5R6 aryl or hydrogen (is A is residue of formula IV or X1 is residue of formula III, (C1-C6) alkoxy (if A is -OCmH2m-X1- and X1 is group of formula III; R3 is hydrogen, (C1-C6) alkyl, (C1-C6) alkoxy (provided that X2 is -CR5R6 aryl or if X1 is group of formula III; R4 is H or (C1-C6) alkyl; R5 and R6 are (C1-C4) alkyl; R7 is alkyl, (C5-C7) cycloalkyl, aryl, heteroaryl with nitrogen atom as heteroatom. Said derivatives have antogonistic effect on receptors of B4 lenkotriene; provided that if A is -OCmH2m-X1-; m is 2,3 or 4, X1 is group of formula III; R2 is H or (C1-C6) alkyl, R3 is H,(C1-C6) alkyl, (C1-C6) alkoxy; R4 is hydrogen or (C1-C6) alkyl, then R1 is other than OH. EFFECT: improved properties of the title compounds. 10 cl, 8 ex
format	Patent
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SUBSTANCE: described are substituted benzamidine derivatives of general formula I: wherein A is O-CmH2m-X1 or group of formula IV: ; m is 2-6; X1 is group formula: ; X3 is O-CnH2n-; X2 is -CnH2n-O-;; n is 1 or 2; R1 is OH, COR7 or COOR7;; R2 is (C1-C6) alkyl, -CR5R6 aryl or hydrogen (is A is residue of formula IV or X1 is residue of formula III, (C1-C6) alkoxy (if A is -OCmH2m-X1- and X1 is group of formula III; R3 is hydrogen, (C1-C6) alkyl, (C1-C6) alkoxy (provided that X2 is -CR5R6 aryl or if X1 is group of formula III; R4 is H or (C1-C6) alkyl; R5 and R6 are (C1-C4) alkyl; R7 is alkyl, (C5-C7) cycloalkyl, aryl, heteroaryl with nitrogen atom as heteroatom. Said derivatives have antogonistic effect on receptors of B4 lenkotriene; provided that if A is -OCmH2m-X1-; m is 2,3 or 4, X1 is group of formula III; R2 is H or (C1-C6) alkyl, R3 is H,(C1-C6) alkyl, (C1-C6) alkoxy; R4 is hydrogen or (C1-C6) alkyl, then R1 is other than OH. EFFECT: improved properties of the title compounds. 10 cl, 8 ex</description><edition>7</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2000</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20001120&DB=EPODOC&CC=RU&NR=2159228C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20001120&DB=EPODOC&CC=RU&NR=2159228C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>EHRNST-OTTO RENT</creatorcontrib><creatorcontrib>FRANTS BIRKE</creatorcontrib><creatorcontrib>RAL'F ANDERSKEVITTS</creatorcontrib><creatorcontrib>KURT SHROMM</creatorcontrib><creatorcontrib>ARMIN FJUGNER</creatorcontrib><creatorcontrib>KRISTOFER MID</creatorcontrib><creatorcontrib>KHUBERT KHOJER</creatorcontrib><title>SUBSTITUTED BENZAMIDINE DERIVATIVES</title><description>medicine. SUBSTANCE: described are substituted benzamidine derivatives of general formula I: wherein A is O-CmH2m-X1 or group of formula IV: ; m is 2-6; X1 is group formula: ; X3 is O-CnH2n-; X2 is -CnH2n-O-;; n is 1 or 2; R1 is OH, COR7 or COOR7;; R2 is (C1-C6) alkyl, -CR5R6 aryl or hydrogen (is A is residue of formula IV or X1 is residue of formula III, (C1-C6) alkoxy (if A is -OCmH2m-X1- and X1 is group of formula III; R3 is hydrogen, (C1-C6) alkyl, (C1-C6) alkoxy (provided that X2 is -CR5R6 aryl or if X1 is group of formula III; R4 is H or (C1-C6) alkyl; R5 and R6 are (C1-C4) alkyl; R7 is alkyl, (C5-C7) cycloalkyl, aryl, heteroaryl with nitrogen atom as heteroatom. Said derivatives have antogonistic effect on receptors of B4 lenkotriene; provided that if A is -OCmH2m-X1-; m is 2,3 or 4, X1 is group of formula III; R2 is H or (C1-C6) alkyl, R3 is H,(C1-C6) alkyl, (C1-C6) alkoxy; R4 is hydrogen or (C1-C6) alkyl, then R1 is other than OH. 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SUBSTANCE: described are substituted benzamidine derivatives of general formula I: wherein A is O-CmH2m-X1 or group of formula IV: ; m is 2-6; X1 is group formula: ; X3 is O-CnH2n-; X2 is -CnH2n-O-;; n is 1 or 2; R1 is OH, COR7 or COOR7;; R2 is (C1-C6) alkyl, -CR5R6 aryl or hydrogen (is A is residue of formula IV or X1 is residue of formula III, (C1-C6) alkoxy (if A is -OCmH2m-X1- and X1 is group of formula III; R3 is hydrogen, (C1-C6) alkyl, (C1-C6) alkoxy (provided that X2 is -CR5R6 aryl or if X1 is group of formula III; R4 is H or (C1-C6) alkyl; R5 and R6 are (C1-C4) alkyl; R7 is alkyl, (C5-C7) cycloalkyl, aryl, heteroaryl with nitrogen atom as heteroatom. Said derivatives have antogonistic effect on receptors of B4 lenkotriene; provided that if A is -OCmH2m-X1-; m is 2,3 or 4, X1 is group of formula III; R2 is H or (C1-C6) alkyl, R3 is H,(C1-C6) alkyl, (C1-C6) alkoxy; R4 is hydrogen or (C1-C6) alkyl, then R1 is other than OH. EFFECT: improved properties of the title compounds. 10 cl, 8 ex</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	SUBSTITUTED BENZAMIDINE DERIVATIVES
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