ANTIVIRAL AGENT - NASAL DROPS "GRIPPFERON"

ANTIVIRAL AGENT - NASAL DROPS "GRIPPFERON"

FIELD: medicine, pharmacology, pharmacy. SUBSTANCE: invention relates to preparing interferon-containing compositions retaining its biological activity that can be used as drugs for intranasal use, for example, for nasal drops preparing. An antiviral agent has interferon, biologically compatible pol...

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Hauptverfasser: MARKOV I.A, GAPONJUK P.JA, MARKOVA E.A
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Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator MARKOV I.A
GAPONJUK P.JA
MARKOVA E.A
description FIELD: medicine, pharmacology, pharmacy. SUBSTANCE: invention relates to preparing interferon-containing compositions retaining its biological activity that can be used as drugs for intranasal use, for example, for nasal drops preparing. An antiviral agent has interferon, biologically compatible polymer and a buffer mixture. An agent has gene engineering interferon as interferon and additionally - an antioxidant at the following ratio of components in 1 ml of buffer mixture: gene engineering interferon 1 000-500 000 IU; biologically compatible polymer 0.005-0.714 g; antioxidant 0.0001-0.0008 g. Except for, an agent has alpha-, beta- or gamma-interferon. Viscosity of obtained agent is (1.1-30.0) x 10 Pa x s. An agent has Trilon B as an antioxidant and polyvinylpyrrolidone and/or polyethylene oxide as a biologically compatible polymer and polyvinylpyrrolidone and polyethylene oxide are taken at the ratio = 1:(1-50). An antiviral agent provides the prolonged contact with nasal mucosa, shows effect at the site of primary incorporation and multiplication of virus and good absorption. EFFECT: improved properties, enhanced effectiveness of an agent. 6 cl, 3 ex
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SUBSTANCE: invention relates to preparing interferon-containing compositions retaining its biological activity that can be used as drugs for intranasal use, for example, for nasal drops preparing. An antiviral agent has interferon, biologically compatible polymer and a buffer mixture. An agent has gene engineering interferon as interferon and additionally - an antioxidant at the following ratio of components in 1 ml of buffer mixture: gene engineering interferon 1 000-500 000 IU; biologically compatible polymer 0.005-0.714 g; antioxidant 0.0001-0.0008 g. Except for, an agent has alpha-, beta- or gamma-interferon. Viscosity of obtained agent is (1.1-30.0) x 10 Pa x s. An agent has Trilon B as an antioxidant and polyvinylpyrrolidone and/or polyethylene oxide as a biologically compatible polymer and polyvinylpyrrolidone and polyethylene oxide are taken at the ratio = 1:(1-50). 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SUBSTANCE: invention relates to preparing interferon-containing compositions retaining its biological activity that can be used as drugs for intranasal use, for example, for nasal drops preparing. An antiviral agent has interferon, biologically compatible polymer and a buffer mixture. An agent has gene engineering interferon as interferon and additionally - an antioxidant at the following ratio of components in 1 ml of buffer mixture: gene engineering interferon 1 000-500 000 IU; biologically compatible polymer 0.005-0.714 g; antioxidant 0.0001-0.0008 g. Except for, an agent has alpha-, beta- or gamma-interferon. Viscosity of obtained agent is (1.1-30.0) x 10 Pa x s. An agent has Trilon B as an antioxidant and polyvinylpyrrolidone and/or polyethylene oxide as a biologically compatible polymer and polyvinylpyrrolidone and polyethylene oxide are taken at the ratio = 1:(1-50). 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SUBSTANCE: invention relates to preparing interferon-containing compositions retaining its biological activity that can be used as drugs for intranasal use, for example, for nasal drops preparing. An antiviral agent has interferon, biologically compatible polymer and a buffer mixture. An agent has gene engineering interferon as interferon and additionally - an antioxidant at the following ratio of components in 1 ml of buffer mixture: gene engineering interferon 1 000-500 000 IU; biologically compatible polymer 0.005-0.714 g; antioxidant 0.0001-0.0008 g. Except for, an agent has alpha-, beta- or gamma-interferon. Viscosity of obtained agent is (1.1-30.0) x 10 Pa x s. An agent has Trilon B as an antioxidant and polyvinylpyrrolidone and/or polyethylene oxide as a biologically compatible polymer and polyvinylpyrrolidone and polyethylene oxide are taken at the ratio = 1:(1-50). 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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ANTIVIRAL AGENT - NASAL DROPS "GRIPPFERON"
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