METHOD FOR PRODUCING DERIVATIVES OF THIAZOLE OR THEIR ACID ADDITIVE SALTS, 5-CHLORO-3-THIOCYANATE-2-ALKANONE AND METHOD FOR ITS PRODUCTION

METHOD FOR PRODUCING DERIVATIVES OF THIAZOLE OR THEIR ACID ADDITIVE SALTS, 5-CHLORO-3-THIOCYANATE-2-ALKANONE AND METHOD FOR ITS PRODUCTION

FIELD: organic chemistry. SUBSTANCE: derivatives of thiazole or their acid additive salts having formula I where R is C2-5-alkyl with unbranched chain and substituted by chlorine atom in 2-position is prepared by interaction of 3,5-dichloro-2-alkanone having formula (V) with inorganic thiocyanate. T...

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Hauptverfasser: KAROJ DJURE, ILDIKO BUTTKAI, EHNDRE PALOSHI, GERGEJ KHEJJA, KAROJ BAN, EHRZHEBET SALAJ, CHABA GENTSI, FERENTS SHPERBER, DERD' MIKHALOVICH, PETER DERI, CHABA KHUSAR, ARPAD KEVARI, FERENTS MORAS, IDA SVOBODA, ISHTVAN BONEJ, MIKHAJ SHJUTE, EHRZHEBET SABO, LASLO LEDNITSKI, EHRZHEBET MOLNAR, PAL KISHSH, SHANDOR GARATSI, ATTILA NEJMET, DEZHE KORBONITS
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:FIELD: organic chemistry. SUBSTANCE: derivatives of thiazole or their acid additive salts having formula I where R is C2-5-alkyl with unbranched chain and substituted by chlorine atom in 2-position is prepared by interaction of 3,5-dichloro-2-alkanone having formula (V) with inorganic thiocyanate. Thus obtained 3-thiocyanate-5-chloro-2-alkanone having formula (IV) is then converted into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole having formula (II). The latter process takes place in organic solvent by interaction with gaseous hydrogen chloride. Then compound having formula (II) is hydrogenated, the process takes place in organic solvent in the presence of metal catalyst. EFFECT: improved efficiency of the method. 15 clm