6-OXO-AZEPINOINDOLE COMPOUNDS AND THEIR PHYSIOLOGICALLY TOLERANTABLE ACID SALTS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS OF THEIR SYNTHESIS
Pharmacologically active compounds corresponding to the general formula I I in which R1 represents hydrogen, a lower alkyl or cycloalkyl-alkyl group or an optionally substituted phenyl-lower alkyl group, R2 denotes hydrogen or a lower alkyl group optionally substituted in the alpha -position to the...
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creator | MARTIN TYULP KARIN VAN KHARLDORP VERNER BENZON ULF PROJSHOFF KLAUS-ULLRIKH VOLF TON KHYULKENBERG PITER KOLIN GREGORI INEKE VAN VEJNGARDEN |
description | Pharmacologically active compounds corresponding to the general formula I I in which R1 represents hydrogen, a lower alkyl or cycloalkyl-alkyl group or an optionally substituted phenyl-lower alkyl group, R2 denotes hydrogen or a lower alkyl group optionally substituted in the alpha -position to the nitrogen atom by lower alkoxy, R3 denotes hydrogen, lower alkyl, lower alkoxy, halogen or hydroxyl, n represents 1 or, if the -(CH2)n- chain is in the 4-position of the ring structure, also represents 2, R4 denotes hydrogen, lower alkyl, cycloalkyl, cycloalkyl-lower alkyl or an optionally substituted phenyl-lower alkyl group, and R5 denotes hydrogen, lower alkyl, cycloalkyl, cycloalkyl-lower alkyl or an optionally substituted phenyl-lower alkyl group, or R4 and R5, together with the nitrogen atom to which they are bonded, form a heterocycle and D represents a bond, or, if R4 and R5 do not denote hydrogen, also represents the -N=CH- group, and their physiologically acceptable acid addition salts are described, and also processes and intermediates for their preparation. |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | 6-OXO-AZEPINOINDOLE COMPOUNDS AND THEIR PHYSIOLOGICALLY TOLERANTABLE ACID SALTS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS OF THEIR SYNTHESIS |
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