3-CYANO -5,4- BIPYRIDINE-1'- OXIDES AND THEIR PHYSIOLOGICALLY COMPATIBLE ACID ADDITION SALTS HAVING CARDIOTONIC AND VASODILATING ACTIVITY

3-CYANO -5,4- BIPYRIDINE-1'- OXIDES AND THEIR PHYSIOLOGICALLY COMPATIBLE ACID ADDITION SALTS HAVING CARDIOTONIC AND VASODILATING ACTIVITY

3-Cyano-5,4'-bipyridine-1'-oxides, 3-cyano-5,4'-bipyridines, 2-chloro-3-cyano-5,4'-bipyridine-1'-oxides, cardiotonic, vasodilatory. … 3-Cyano-5,4'-bipyridine-1'-oxides of the general formula I and their physiologically tolerable acid addition salts have useful card...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SABINE KHEER, KHANS-JOAKHIM ENSH, ERKHARD KLAUSHENTS, FOLKER KHAGEN, BRIGITTE SHLEGEL, PETER MUSHIK, GOTTFRID FAUST, ANGELA KHAGEN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:3-Cyano-5,4'-bipyridine-1'-oxides, 3-cyano-5,4'-bipyridines, 2-chloro-3-cyano-5,4'-bipyridine-1'-oxides, cardiotonic, vasodilatory. … 3-Cyano-5,4'-bipyridine-1'-oxides of the general formula I and their physiologically tolerable acid addition salts have useful cardiotonic and vasodilatory properties. They can be prepared by either … …  a) reacting 3-cyano-5,4'-bipyridines of the formula II with reagents suitable for the production of pyridine-N-oxides, preferably peracids or hydrogen superoxide, or …  b) reacting 2-chloro-3-cyano-5,4'-bipyridine-1'-oxides of the formula III with a compound of the formula IV and if desired converting the compounds of the formula I obtained into their acid addition salts with physiologically tolerable inorganic or organic acids. …