MULTISPECIFIC ANTIBODIES FACILITATING SELECTIVE LIGHT CHAIN PAIRING

MULTISPECIFIC ANTIBODIES FACILITATING SELECTIVE LIGHT CHAIN PAIRING

Provided herein are multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. Also disclosed herein are nucleic a...

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Hauptverfasser: LEUSCHNER, WULF-DIRK, RAO, ERCOLE, SPINDLER, NADJA, LANGER, THOMAS, LANGE, CHRISTIAN, BEIL, CHRISTIAN, KROLL, KATJA, FOCKEN, INGO
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CHEMISTRY
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ORGANIC CHEMISTRY
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creator LEUSCHNER, WULF-DIRK
RAO, ERCOLE
SPINDLER, NADJA
LANGER, THOMAS
LANGE, CHRISTIAN
BEIL, CHRISTIAN
KROLL, KATJA
FOCKEN, INGO
description Provided herein are multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. Also disclosed herein are nucleic acids encoding for these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions comprising the antibodies, as well as methods of isolating the antibodies.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title MULTISPECIFIC ANTIBODIES FACILITATING SELECTIVE LIGHT CHAIN PAIRING
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