RECOMBINANT HUMAN ACID ALPHA-GLUCOSIDASE

RECOMBINANT HUMAN ACID ALPHA-GLUCOSIDASE

Provided are a recombinant acid α-glucosidase and pharmaceutical composition comprising a recombinant acid α- glucosidase, wherein the recombinant acid α-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises an increased content of N-glycan units bearing one or two mannose-6-ph...

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Hauptverfasser: SUNDERLAND, WENDY, KHANNA, RICHIE, GOTSCHALL, RUSSELL, TESLER, SERGEY, DILONÉ, ENRIQUE, DO, HUNG, CHAR, HING, LUN, YI
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Sprache:eng ; srp
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator SUNDERLAND, WENDY
KHANNA, RICHIE
GOTSCHALL, RUSSELL
TESLER, SERGEY
DILONÉ, ENRIQUE
DO, HUNG
CHAR, HING
LUN, YI
description Provided are a recombinant acid α-glucosidase and pharmaceutical composition comprising a recombinant acid α- glucosidase, wherein the recombinant acid α-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises an increased content of N-glycan units bearing one or two mannose-6-phosphate residues when compared to a content of N-glycan units bearing one or two mannose-6-phosphate residues of alglucosidase alfa. Also provided herein are methods of producing, purifying, and formulating the recombinant acid α-glucosidase or pharmaceutical composition for administration to a subject and methods of treating a disease or disorder such as Pompe disease using the recombinant acid α-glucosidase or pharmaceutical composition.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title RECOMBINANT HUMAN ACID ALPHA-GLUCOSIDASE
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