PYRAZOLES AS 11-BETA-HSD-1
Jedinjenje formule (I): u kojoj: R1 je vodonik; R2 je adamantan, nesupstituisan ili supstituisan sa hidroksi, ili halogenom; R3 je: trifluorometil, pirazol, triazol, piperidin, pirolidin, hidroksimetil piperidin, benzilpiperazin, hidroksipirolidin, terc-butil pirolidin, hidroksietil piperazin, hidro...
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| creator | QI, LIDA TILLEY, JEFFERSON WRIGHT PIETRANICO-COLE, SHERRIE LYNN FOTOUHI, NADER MYERS, MICHAEL PAUL GILLESPIE, PAUL HAYNES, NANCY-ELLEN GOODNOW, ROBERT ALAN JR ROSSMAN, PAMELA LOREEN ANDERSON, KEVIN WILLIAM DR ZHANG, QIANG SCOTT, NATHAN ROBERT THAKKAR, KSHITIJ CHHABILBHAI GUERTIN, KEVIN RICHARD |
| description | Jedinjenje formule (I): u kojoj: R1 je vodonik; R2 je adamantan, nesupstituisan ili supstituisan sa hidroksi, ili halogenom; R3 je: trifluorometil, pirazol, triazol, piperidin, pirolidin, hidroksimetil piperidin, benzilpiperazin, hidroksipirolidin, terc-butil pirolidin, hidroksietil piperazin, hidroksipiperidin ili tiomorfolin grupa; R4 je: ciklopropil, terc-butil, -C(CH3)2CH2OH, metil, -CF3 ili -(CH2)nCF3 grupa, pri čemu je n 1 ili 2; R5 je vodonik ili C1-C7-alkil, koji nije supstituisan ili je supstituisan sa halogenom; i njegove farmaceutski prihvatljive soli. Prijava sadrži još 22 patentna zahteva.
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome. |
| format | Patent |
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Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.</description><language>eng ; srp</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151231&DB=EPODOC&CC=RS&NR=54216B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151231&DB=EPODOC&CC=RS&NR=54216B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>QI, LIDA</creatorcontrib><creatorcontrib>TILLEY, JEFFERSON WRIGHT</creatorcontrib><creatorcontrib>PIETRANICO-COLE, SHERRIE LYNN</creatorcontrib><creatorcontrib>FOTOUHI, NADER</creatorcontrib><creatorcontrib>MYERS, MICHAEL PAUL</creatorcontrib><creatorcontrib>GILLESPIE, PAUL</creatorcontrib><creatorcontrib>HAYNES, NANCY-ELLEN</creatorcontrib><creatorcontrib>GOODNOW, ROBERT ALAN JR</creatorcontrib><creatorcontrib>ROSSMAN, PAMELA LOREEN</creatorcontrib><creatorcontrib>ANDERSON, KEVIN WILLIAM DR</creatorcontrib><creatorcontrib>ZHANG, QIANG</creatorcontrib><creatorcontrib>SCOTT, NATHAN ROBERT</creatorcontrib><creatorcontrib>THAKKAR, KSHITIJ CHHABILBHAI</creatorcontrib><creatorcontrib>GUERTIN, KEVIN RICHARD</creatorcontrib><title>PYRAZOLES AS 11-BETA-HSD-1</title><description>Jedinjenje formule (I): u kojoj: R1 je vodonik; R2 je adamantan, nesupstituisan ili supstituisan sa hidroksi, ili halogenom; R3 je: trifluorometil, pirazol, triazol, piperidin, pirolidin, hidroksimetil piperidin, benzilpiperazin, hidroksipirolidin, terc-butil pirolidin, hidroksietil piperazin, hidroksipiperidin ili tiomorfolin grupa; R4 je: ciklopropil, terc-butil, -C(CH3)2CH2OH, metil, -CF3 ili -(CH2)nCF3 grupa, pri čemu je n 1 ili 2; R5 je vodonik ili C1-C7-alkil, koji nije supstituisan ili je supstituisan sa halogenom; i njegove farmaceutski prihvatljive soli. Prijava sadrži još 22 patentna zahteva.
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJAKiAxyjPL3cQ1WcAxWMDTUdXINcdT1CHbRNeRhYE1LzClO5YXS3Axybq4hzh66qQX58anFBYnJqXmpJfFBwaYmRoZmTobGBBUAAFF9Hp0</recordid><startdate>20151231</startdate><enddate>20151231</enddate><creator>QI, LIDA</creator><creator>TILLEY, JEFFERSON WRIGHT</creator><creator>PIETRANICO-COLE, SHERRIE LYNN</creator><creator>FOTOUHI, NADER</creator><creator>MYERS, MICHAEL PAUL</creator><creator>GILLESPIE, PAUL</creator><creator>HAYNES, NANCY-ELLEN</creator><creator>GOODNOW, ROBERT ALAN JR</creator><creator>ROSSMAN, PAMELA LOREEN</creator><creator>ANDERSON, KEVIN WILLIAM DR</creator><creator>ZHANG, QIANG</creator><creator>SCOTT, NATHAN ROBERT</creator><creator>THAKKAR, KSHITIJ CHHABILBHAI</creator><creator>GUERTIN, KEVIN RICHARD</creator><scope>EVB</scope></search><sort><creationdate>20151231</creationdate><title>PYRAZOLES AS 11-BETA-HSD-1</title><author>QI, LIDA ; TILLEY, JEFFERSON WRIGHT ; PIETRANICO-COLE, SHERRIE LYNN ; FOTOUHI, NADER ; MYERS, MICHAEL PAUL ; GILLESPIE, PAUL ; HAYNES, NANCY-ELLEN ; GOODNOW, ROBERT ALAN JR ; ROSSMAN, PAMELA LOREEN ; ANDERSON, KEVIN WILLIAM DR ; ZHANG, QIANG ; SCOTT, NATHAN ROBERT ; THAKKAR, KSHITIJ CHHABILBHAI ; GUERTIN, KEVIN RICHARD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RS54216B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; srp</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>QI, LIDA</creatorcontrib><creatorcontrib>TILLEY, JEFFERSON WRIGHT</creatorcontrib><creatorcontrib>PIETRANICO-COLE, SHERRIE LYNN</creatorcontrib><creatorcontrib>FOTOUHI, NADER</creatorcontrib><creatorcontrib>MYERS, MICHAEL PAUL</creatorcontrib><creatorcontrib>GILLESPIE, PAUL</creatorcontrib><creatorcontrib>HAYNES, NANCY-ELLEN</creatorcontrib><creatorcontrib>GOODNOW, ROBERT ALAN JR</creatorcontrib><creatorcontrib>ROSSMAN, PAMELA LOREEN</creatorcontrib><creatorcontrib>ANDERSON, KEVIN WILLIAM DR</creatorcontrib><creatorcontrib>ZHANG, QIANG</creatorcontrib><creatorcontrib>SCOTT, NATHAN ROBERT</creatorcontrib><creatorcontrib>THAKKAR, KSHITIJ CHHABILBHAI</creatorcontrib><creatorcontrib>GUERTIN, KEVIN RICHARD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>QI, LIDA</au><au>TILLEY, JEFFERSON WRIGHT</au><au>PIETRANICO-COLE, SHERRIE LYNN</au><au>FOTOUHI, NADER</au><au>MYERS, MICHAEL PAUL</au><au>GILLESPIE, PAUL</au><au>HAYNES, NANCY-ELLEN</au><au>GOODNOW, ROBERT ALAN JR</au><au>ROSSMAN, PAMELA LOREEN</au><au>ANDERSON, KEVIN WILLIAM DR</au><au>ZHANG, QIANG</au><au>SCOTT, NATHAN ROBERT</au><au>THAKKAR, KSHITIJ CHHABILBHAI</au><au>GUERTIN, KEVIN RICHARD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRAZOLES AS 11-BETA-HSD-1</title><date>2015-12-31</date><risdate>2015</risdate><abstract>Jedinjenje formule (I): u kojoj: R1 je vodonik; R2 je adamantan, nesupstituisan ili supstituisan sa hidroksi, ili halogenom; R3 je: trifluorometil, pirazol, triazol, piperidin, pirolidin, hidroksimetil piperidin, benzilpiperazin, hidroksipirolidin, terc-butil pirolidin, hidroksietil piperazin, hidroksipiperidin ili tiomorfolin grupa; R4 je: ciklopropil, terc-butil, -C(CH3)2CH2OH, metil, -CF3 ili -(CH2)nCF3 grupa, pri čemu je n 1 ili 2; R5 je vodonik ili C1-C7-alkil, koji nije supstituisan ili je supstituisan sa halogenom; i njegove farmaceutski prihvatljive soli. Prijava sadrži još 22 patentna zahteva.
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PYRAZOLES AS 11-BETA-HSD-1 |
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