NEW PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF FUNGAL INFECTIONS

Tečna farmaceutska formulacija u vidu rastvora pogodna za topikalnu primenu na kožu i/ili noktima koja težinski, u odnosu na ukupnu težinu formulacije, sadrži: (a) 1% do 35% komponente bazirane na urei; (b) 40% do 80% diolske komponente; (c) 1% do 20% organske kiseline; i (d) 4,5% do 12% triolske ko...

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Hauptverfasser: ASHKAR, SAHAR FEIZOLLAHI, KARLSSON, EWA, KAUFMANN, PETER
Format: Patent
Sprache:eng ; srp
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Zusammenfassung:Tečna farmaceutska formulacija u vidu rastvora pogodna za topikalnu primenu na kožu i/ili noktima koja težinski, u odnosu na ukupnu težinu formulacije, sadrži: (a) 1% do 35% komponente bazirane na urei; (b) 40% do 80% diolske komponente; (c) 1% do 20% organske kiseline; i (d) 4,5% do 12% triolske komponente; kao i (e) vodeni rastvor baze u količini dovoljnoj da se obezbedi finalni pH formulacije u opsegu od 2 do 6. Prijava sadrži još 13 patentnih zahteva. There is provided pharmaceutical compositions suitable for topical application to the nail for the treatment of nail diseases such as onychomycosis, comprising a urea-based component, a diol component, such as propylene glycol, an organic acid component, such as lactic acid, and a triol component, such a glycerol. There is further provided methods of improving the storage stability of a pharmaceutical composition suitable for topical application to the skin and/or nails comprising such urea-based components, diol components, organic acid components, and, optionally, an aqueous base, which method comprises adding a triol component, such a glycerol, to that composition prior to said storage.