NOVEL COMPOUNDS
Jedinjenje, nazna eno time, da ima formulu (I)Gde R1 i R3 su isti ili razli iti, ali su nezavisno izabrani iz H, (C1-C6) alkila, (C3-C7) cikloalkila, halo, CN, OF3, -O-(C1-C6)alkila, -CO2-(C1-C6)alkila, COOH, -CONH-(C1-C6)alkila, -CONH-arila, -NH2, -CONH-R6, - CONR5, -C1-C3alkil-arila, -(C1-C3) alki...
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| creator | GUPTA, RAMESH TULI, DAVINDER ZAMBAD, SHITALKUMAR PUKHARAJ BHATTAMISRA, SUBRAT, KUMAR MUNSHI, SIRALEE CHAUTHAIWALE, VIJAY SIDDIQUI, AMIR, M CHHIPA, LAXMIKANT KASUNDRA, ASHOK DUTT, C |
| description | Jedinjenje, nazna eno time, da ima formulu (I)Gde R1 i R3 su isti ili razli iti, ali su nezavisno izabrani iz H, (C1-C6) alkila, (C3-C7) cikloalkila, halo, CN, OF3, -O-(C1-C6)alkila, -CO2-(C1-C6)alkila, COOH, -CONH-(C1-C6)alkila, -CONH-arila, -NH2, -CONH-R6, - CONR5, -C1-C3alkil-arila, -(C1-C3) alkil-R6, -NH-(C1-C6)alkila, -NHarila, -NH-SO2-(C1-C6)alkila, -CH2-NH-(C1-C6)alkila, -CH2-O-(C1-C6)alkila, -C1-C3alkil-NR5, R6, R7, gde C1-C6alkil i C3-C7 cikloalkil su ponekad supstituisani sa jednim ili više supstituenata izabranih iz (C1-C6)alkila, halo, cijano, -OH, okso, -COOH, -O-(C1-C6)alkila, -O-benzila, -COO-(C1-C6)alkila, -CONH-(C1-C6)alkila, -CONR5, -CONH-arila, -CONH-heteroarila ili -CH2NR5;R2 je izabran iz (C1-C6)alkila, (C3-C6)cikloalkila, (C3-C6)alkenila, (C3-C6)alkinila, -C(O)-(C1-C3)alkil-COOH, -(C1- C3)alkil-COOH, -C(O)-(C1-C3)alkil-COO-alkila, -C(O)-C(O)O-(C1-C6)alkila, -C(O)-(C1-C3)alkil-NH-(C1-C6)alkila, -O(O)-O-(C1-C6)alkila, -C(O)NR5, -C(O)NH-(C1-C6)alkila, -C(O)-(C1-C3)alkilarila, -O(O)-(C1-C3)alkil-R6, R6, R7, gde pomenuti (C1-C6)alkil, (C3-C6)cikloalkil, (C3-C6)alkenil, (C3-C6)alkinil su ponekad supstituisani sa jednim ili više supstituenata izabranih iz perhaloalkila, Okso, -C(O)OH, -C(O)-O-(C1-C3)alkila, -C(O)-O-(C1-C3)alkil-arila, -C(O)-O-(C1-C3)alkil-R6, -CONH2,-CONH(C1-C3)alkila, -C(O)NH-arila, -C(O)NH-R6, -CONR5-CONHNH2,-C(=NH)NH-(C1-C6)alkila, -C(=NH)NH2, C(=NH)NHOH, -C(O)-R8,-C(O)NHSO2(C1-C6) alkila, -C(O)NHSO2-arila, -C(O)NHOH, -C(O)NHSO2-R6, -C(O)NHNH-(C1-C6)alkila, -C(O)NHNH-arila, -CONH-(C1-C2)alkil-arila, -C(O)NH-(C1-C2)alkil-R6, -CH2NR5, -NH2, -NH-(C1-C6)alkila, -NH-C(O)-O-(C1-C3)alkila, -NH-C(O)-(C1-C3)alkila, -NHC(O)-arila, -NHC(O)-(C1-C3)alkilarila, -NHC(O)-R6, -NH-C(O)NR5, -NH-C(O)NH-arila, -NHC(O)NH-(C1-C6)alkila, - NHSO2(C1-C6)alkila, -NH-SO2-arila, -NH-SO2-R6, halo, cijano, -OH, -O-(C1-C6)alkila, -O-arila, -O-¬heteroarila, -O-(C1-C2)alkil-arila, -SO3H, -SO2NH-arila, -SO2NH-R6 ili -SO2NH-(C1-C6)alkila, R6 ili R7;R5 zajedno sa Azotnim atomom na kojeg je spojen formira zasi eni ili nezasi eni (C3-C6)- lani prsten, koji mo e dodatno da sadr i 1-2 heteroatoma izabrana iz O, N ili S, a koji mogu da budu ponekad supstituisani sa jednim ili više supstituenata izabrana iz okso, -COOH, halo,-OH, -O-(C1-C6)alkila ili -(C1-C6)alkila;R6 je izabran iz fenila ili 5-8- lanog heteroarila koji sadr i 1-4 heteroatoma izabrana iz O, N ili S, a gde pomenuti heteroarilni ili fenilni prstenje ponekad supstituisan sa jednim ili više supstituen |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_RS51501B</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>RS51501B</sourcerecordid><originalsourceid>FETCH-epo_espacenet_RS51501B3</originalsourceid><addsrcrecordid>eNrjZOD38w9z9VFw9vcN8A_1cwnmYWBNS8wpTuWF0twMsm6uIc4euqkF-fGpxQWJyal5qSXxQcGmhqYGhk7GhOQBGQUbzA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NOVEL COMPOUNDS</title><source>esp@cenet</source><creator>GUPTA, RAMESH ; TULI, DAVINDER ; ZAMBAD, SHITALKUMAR PUKHARAJ ; BHATTAMISRA, SUBRAT, KUMAR ; MUNSHI, SIRALEE ; CHAUTHAIWALE, VIJAY ; SIDDIQUI, AMIR, M ; CHHIPA, LAXMIKANT ; KASUNDRA, ASHOK ; DUTT, C</creator><creatorcontrib>GUPTA, RAMESH ; TULI, DAVINDER ; ZAMBAD, SHITALKUMAR PUKHARAJ ; BHATTAMISRA, SUBRAT, KUMAR ; MUNSHI, SIRALEE ; CHAUTHAIWALE, VIJAY ; SIDDIQUI, AMIR, M ; CHHIPA, LAXMIKANT ; KASUNDRA, ASHOK ; DUTT, C</creatorcontrib><description>Jedinjenje, nazna eno time, da ima formulu (I)Gde R1 i R3 su isti ili razli iti, ali su nezavisno izabrani iz H, (C1-C6) alkila, (C3-C7) cikloalkila, halo, CN, OF3, -O-(C1-C6)alkila, -CO2-(C1-C6)alkila, COOH, -CONH-(C1-C6)alkila, -CONH-arila, -NH2, -CONH-R6, - CONR5, -C1-C3alkil-arila, -(C1-C3) alkil-R6, -NH-(C1-C6)alkila, -NHarila, -NH-SO2-(C1-C6)alkila, -CH2-NH-(C1-C6)alkila, -CH2-O-(C1-C6)alkila, -C1-C3alkil-NR5, R6, R7, gde C1-C6alkil i C3-C7 cikloalkil su ponekad supstituisani sa jednim ili više supstituenata izabranih iz (C1-C6)alkila, halo, cijano, -OH, okso, -COOH, -O-(C1-C6)alkila, -O-benzila, -COO-(C1-C6)alkila, -CONH-(C1-C6)alkila, -CONR5, -CONH-arila, -CONH-heteroarila ili -CH2NR5;R2 je izabran iz (C1-C6)alkila, (C3-C6)cikloalkila, (C3-C6)alkenila, (C3-C6)alkinila, -C(O)-(C1-C3)alkil-COOH, -(C1- C3)alkil-COOH, -C(O)-(C1-C3)alkil-COO-alkila, -C(O)-C(O)O-(C1-C6)alkila, -C(O)-(C1-C3)alkil-NH-(C1-C6)alkila, -O(O)-O-(C1-C6)alkila, -C(O)NR5, -C(O)NH-(C1-C6)alkila, -C(O)-(C1-C3)alkilarila, -O(O)-(C1-C3)alkil-R6, R6, R7, gde pomenuti (C1-C6)alkil, (C3-C6)cikloalkil, (C3-C6)alkenil, (C3-C6)alkinil su ponekad supstituisani sa jednim ili više supstituenata izabranih iz perhaloalkila, Okso, -C(O)OH, -C(O)-O-(C1-C3)alkila, -C(O)-O-(C1-C3)alkil-arila, -C(O)-O-(C1-C3)alkil-R6, -CONH2,-CONH(C1-C3)alkila, -C(O)NH-arila, -C(O)NH-R6, -CONR5-CONHNH2,-C(=NH)NH-(C1-C6)alkila, -C(=NH)NH2, C(=NH)NHOH, -C(O)-R8,-C(O)NHSO2(C1-C6) alkila, -C(O)NHSO2-arila, -C(O)NHOH, -C(O)NHSO2-R6, -C(O)NHNH-(C1-C6)alkila, -C(O)NHNH-arila, -CONH-(C1-C2)alkil-arila, -C(O)NH-(C1-C2)alkil-R6, -CH2NR5, -NH2, -NH-(C1-C6)alkila, -NH-C(O)-O-(C1-C3)alkila, -NH-C(O)-(C1-C3)alkila, -NHC(O)-arila, -NHC(O)-(C1-C3)alkilarila, -NHC(O)-R6, -NH-C(O)NR5, -NH-C(O)NH-arila, -NHC(O)NH-(C1-C6)alkila, - NHSO2(C1-C6)alkila, -NH-SO2-arila, -NH-SO2-R6, halo, cijano, -OH, -O-(C1-C6)alkila, -O-arila, -O-¬heteroarila, -O-(C1-C2)alkil-arila, -SO3H, -SO2NH-arila, -SO2NH-R6 ili -SO2NH-(C1-C6)alkila, R6 ili R7;R5 zajedno sa Azotnim atomom na kojeg je spojen formira zasi eni ili nezasi eni (C3-C6)- lani prsten, koji mo e dodatno da sadr i 1-2 heteroatoma izabrana iz O, N ili S, a koji mogu da budu ponekad supstituisani sa jednim ili više supstituenata izabrana iz okso, -COOH, halo,-OH, -O-(C1-C6)alkila ili -(C1-C6)alkila;R6 je izabran iz fenila ili 5-8- lanog heteroarila koji sadr i 1-4 heteroatoma izabrana iz O, N ili S, a gde pomenuti heteroarilni ili fenilni prstenje ponekad supstituisan sa jednim ili više supstituenata izabrana iz halogena, -OH, -O-(C1-C6)alkila, -perhaloalkila, -(C1-C6)alkila, -(C3-C6)cikloalkila, -SO2(C1-C6)alkila, cijano, -COOH, -C(O)O-(C,-C6)alkila, -C(O)O-CH2-arila, C(O)O-arila, -CONH(C1-C3)alkila, nitro, -NH2, -NH-(C1-C6)alkila, -NHC(O)- (C,-C6)alkila, -NHC(O)-arila, -NHSO2(C1-C5)alkila. -CONH2, -SO2-(C1-C6)alkila, - NHSO2(C1-C6)alkila ili -COR8;R7 je 3-6- lani heterocikli ki prs
The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.</description><language>eng ; srp</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110430&DB=EPODOC&CC=RS&NR=51501B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110430&DB=EPODOC&CC=RS&NR=51501B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GUPTA, RAMESH</creatorcontrib><creatorcontrib>TULI, DAVINDER</creatorcontrib><creatorcontrib>ZAMBAD, SHITALKUMAR PUKHARAJ</creatorcontrib><creatorcontrib>BHATTAMISRA, SUBRAT, KUMAR</creatorcontrib><creatorcontrib>MUNSHI, SIRALEE</creatorcontrib><creatorcontrib>CHAUTHAIWALE, VIJAY</creatorcontrib><creatorcontrib>SIDDIQUI, AMIR, M</creatorcontrib><creatorcontrib>CHHIPA, LAXMIKANT</creatorcontrib><creatorcontrib>KASUNDRA, ASHOK</creatorcontrib><creatorcontrib>DUTT, C</creatorcontrib><title>NOVEL COMPOUNDS</title><description>Jedinjenje, nazna eno time, da ima formulu (I)Gde R1 i R3 su isti ili razli iti, ali su nezavisno izabrani iz H, (C1-C6) alkila, (C3-C7) cikloalkila, halo, CN, OF3, -O-(C1-C6)alkila, -CO2-(C1-C6)alkila, COOH, -CONH-(C1-C6)alkila, -CONH-arila, -NH2, -CONH-R6, - CONR5, -C1-C3alkil-arila, -(C1-C3) alkil-R6, -NH-(C1-C6)alkila, -NHarila, -NH-SO2-(C1-C6)alkila, -CH2-NH-(C1-C6)alkila, -CH2-O-(C1-C6)alkila, -C1-C3alkil-NR5, R6, R7, gde C1-C6alkil i C3-C7 cikloalkil su ponekad supstituisani sa jednim ili više supstituenata izabranih iz (C1-C6)alkila, halo, cijano, -OH, okso, -COOH, -O-(C1-C6)alkila, -O-benzila, -COO-(C1-C6)alkila, -CONH-(C1-C6)alkila, -CONR5, -CONH-arila, -CONH-heteroarila ili -CH2NR5;R2 je izabran iz (C1-C6)alkila, (C3-C6)cikloalkila, (C3-C6)alkenila, (C3-C6)alkinila, -C(O)-(C1-C3)alkil-COOH, -(C1- C3)alkil-COOH, -C(O)-(C1-C3)alkil-COO-alkila, -C(O)-C(O)O-(C1-C6)alkila, -C(O)-(C1-C3)alkil-NH-(C1-C6)alkila, -O(O)-O-(C1-C6)alkila, -C(O)NR5, -C(O)NH-(C1-C6)alkila, -C(O)-(C1-C3)alkilarila, -O(O)-(C1-C3)alkil-R6, R6, R7, gde pomenuti (C1-C6)alkil, (C3-C6)cikloalkil, (C3-C6)alkenil, (C3-C6)alkinil su ponekad supstituisani sa jednim ili više supstituenata izabranih iz perhaloalkila, Okso, -C(O)OH, -C(O)-O-(C1-C3)alkila, -C(O)-O-(C1-C3)alkil-arila, -C(O)-O-(C1-C3)alkil-R6, -CONH2,-CONH(C1-C3)alkila, -C(O)NH-arila, -C(O)NH-R6, -CONR5-CONHNH2,-C(=NH)NH-(C1-C6)alkila, -C(=NH)NH2, C(=NH)NHOH, -C(O)-R8,-C(O)NHSO2(C1-C6) alkila, -C(O)NHSO2-arila, -C(O)NHOH, -C(O)NHSO2-R6, -C(O)NHNH-(C1-C6)alkila, -C(O)NHNH-arila, -CONH-(C1-C2)alkil-arila, -C(O)NH-(C1-C2)alkil-R6, -CH2NR5, -NH2, -NH-(C1-C6)alkila, -NH-C(O)-O-(C1-C3)alkila, -NH-C(O)-(C1-C3)alkila, -NHC(O)-arila, -NHC(O)-(C1-C3)alkilarila, -NHC(O)-R6, -NH-C(O)NR5, -NH-C(O)NH-arila, -NHC(O)NH-(C1-C6)alkila, - NHSO2(C1-C6)alkila, -NH-SO2-arila, -NH-SO2-R6, halo, cijano, -OH, -O-(C1-C6)alkila, -O-arila, -O-¬heteroarila, -O-(C1-C2)alkil-arila, -SO3H, -SO2NH-arila, -SO2NH-R6 ili -SO2NH-(C1-C6)alkila, R6 ili R7;R5 zajedno sa Azotnim atomom na kojeg je spojen formira zasi eni ili nezasi eni (C3-C6)- lani prsten, koji mo e dodatno da sadr i 1-2 heteroatoma izabrana iz O, N ili S, a koji mogu da budu ponekad supstituisani sa jednim ili više supstituenata izabrana iz okso, -COOH, halo,-OH, -O-(C1-C6)alkila ili -(C1-C6)alkila;R6 je izabran iz fenila ili 5-8- lanog heteroarila koji sadr i 1-4 heteroatoma izabrana iz O, N ili S, a gde pomenuti heteroarilni ili fenilni prstenje ponekad supstituisan sa jednim ili više supstituenata izabrana iz halogena, -OH, -O-(C1-C6)alkila, -perhaloalkila, -(C1-C6)alkila, -(C3-C6)cikloalkila, -SO2(C1-C6)alkila, cijano, -COOH, -C(O)O-(C,-C6)alkila, -C(O)O-CH2-arila, C(O)O-arila, -CONH(C1-C3)alkila, nitro, -NH2, -NH-(C1-C6)alkila, -NHC(O)- (C,-C6)alkila, -NHC(O)-arila, -NHSO2(C1-C5)alkila. -CONH2, -SO2-(C1-C6)alkila, - NHSO2(C1-C6)alkila ili -COR8;R7 je 3-6- lani heterocikli ki prs
The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOD38w9z9VFw9vcN8A_1cwnmYWBNS8wpTuWF0twMsm6uIc4euqkF-fGpxQWJyal5qSXxQcGmhqYGhk7GhOQBGQUbzA</recordid><startdate>20110430</startdate><enddate>20110430</enddate><creator>GUPTA, RAMESH</creator><creator>TULI, DAVINDER</creator><creator>ZAMBAD, SHITALKUMAR PUKHARAJ</creator><creator>BHATTAMISRA, SUBRAT, KUMAR</creator><creator>MUNSHI, SIRALEE</creator><creator>CHAUTHAIWALE, VIJAY</creator><creator>SIDDIQUI, AMIR, M</creator><creator>CHHIPA, LAXMIKANT</creator><creator>KASUNDRA, ASHOK</creator><creator>DUTT, C</creator><scope>EVB</scope></search><sort><creationdate>20110430</creationdate><title>NOVEL COMPOUNDS</title><author>GUPTA, RAMESH ; TULI, DAVINDER ; ZAMBAD, SHITALKUMAR PUKHARAJ ; BHATTAMISRA, SUBRAT, KUMAR ; MUNSHI, SIRALEE ; CHAUTHAIWALE, VIJAY ; SIDDIQUI, AMIR, M ; CHHIPA, LAXMIKANT ; KASUNDRA, ASHOK ; DUTT, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RS51501B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; srp</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GUPTA, RAMESH</creatorcontrib><creatorcontrib>TULI, DAVINDER</creatorcontrib><creatorcontrib>ZAMBAD, SHITALKUMAR PUKHARAJ</creatorcontrib><creatorcontrib>BHATTAMISRA, SUBRAT, KUMAR</creatorcontrib><creatorcontrib>MUNSHI, SIRALEE</creatorcontrib><creatorcontrib>CHAUTHAIWALE, VIJAY</creatorcontrib><creatorcontrib>SIDDIQUI, AMIR, M</creatorcontrib><creatorcontrib>CHHIPA, LAXMIKANT</creatorcontrib><creatorcontrib>KASUNDRA, ASHOK</creatorcontrib><creatorcontrib>DUTT, C</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GUPTA, RAMESH</au><au>TULI, DAVINDER</au><au>ZAMBAD, SHITALKUMAR PUKHARAJ</au><au>BHATTAMISRA, SUBRAT, KUMAR</au><au>MUNSHI, SIRALEE</au><au>CHAUTHAIWALE, VIJAY</au><au>SIDDIQUI, AMIR, M</au><au>CHHIPA, LAXMIKANT</au><au>KASUNDRA, ASHOK</au><au>DUTT, C</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL COMPOUNDS</title><date>2011-04-30</date><risdate>2011</risdate><abstract>Jedinjenje, nazna eno time, da ima formulu (I)Gde R1 i R3 su isti ili razli iti, ali su nezavisno izabrani iz H, (C1-C6) alkila, (C3-C7) cikloalkila, halo, CN, OF3, -O-(C1-C6)alkila, -CO2-(C1-C6)alkila, COOH, -CONH-(C1-C6)alkila, -CONH-arila, -NH2, -CONH-R6, - CONR5, -C1-C3alkil-arila, -(C1-C3) alkil-R6, -NH-(C1-C6)alkila, -NHarila, -NH-SO2-(C1-C6)alkila, -CH2-NH-(C1-C6)alkila, -CH2-O-(C1-C6)alkila, -C1-C3alkil-NR5, R6, R7, gde C1-C6alkil i C3-C7 cikloalkil su ponekad supstituisani sa jednim ili više supstituenata izabranih iz (C1-C6)alkila, halo, cijano, -OH, okso, -COOH, -O-(C1-C6)alkila, -O-benzila, -COO-(C1-C6)alkila, -CONH-(C1-C6)alkila, -CONR5, -CONH-arila, -CONH-heteroarila ili -CH2NR5;R2 je izabran iz (C1-C6)alkila, (C3-C6)cikloalkila, (C3-C6)alkenila, (C3-C6)alkinila, -C(O)-(C1-C3)alkil-COOH, -(C1- C3)alkil-COOH, -C(O)-(C1-C3)alkil-COO-alkila, -C(O)-C(O)O-(C1-C6)alkila, -C(O)-(C1-C3)alkil-NH-(C1-C6)alkila, -O(O)-O-(C1-C6)alkila, -C(O)NR5, -C(O)NH-(C1-C6)alkila, -C(O)-(C1-C3)alkilarila, -O(O)-(C1-C3)alkil-R6, R6, R7, gde pomenuti (C1-C6)alkil, (C3-C6)cikloalkil, (C3-C6)alkenil, (C3-C6)alkinil su ponekad supstituisani sa jednim ili više supstituenata izabranih iz perhaloalkila, Okso, -C(O)OH, -C(O)-O-(C1-C3)alkila, -C(O)-O-(C1-C3)alkil-arila, -C(O)-O-(C1-C3)alkil-R6, -CONH2,-CONH(C1-C3)alkila, -C(O)NH-arila, -C(O)NH-R6, -CONR5-CONHNH2,-C(=NH)NH-(C1-C6)alkila, -C(=NH)NH2, C(=NH)NHOH, -C(O)-R8,-C(O)NHSO2(C1-C6) alkila, -C(O)NHSO2-arila, -C(O)NHOH, -C(O)NHSO2-R6, -C(O)NHNH-(C1-C6)alkila, -C(O)NHNH-arila, -CONH-(C1-C2)alkil-arila, -C(O)NH-(C1-C2)alkil-R6, -CH2NR5, -NH2, -NH-(C1-C6)alkila, -NH-C(O)-O-(C1-C3)alkila, -NH-C(O)-(C1-C3)alkila, -NHC(O)-arila, -NHC(O)-(C1-C3)alkilarila, -NHC(O)-R6, -NH-C(O)NR5, -NH-C(O)NH-arila, -NHC(O)NH-(C1-C6)alkila, - NHSO2(C1-C6)alkila, -NH-SO2-arila, -NH-SO2-R6, halo, cijano, -OH, -O-(C1-C6)alkila, -O-arila, -O-¬heteroarila, -O-(C1-C2)alkil-arila, -SO3H, -SO2NH-arila, -SO2NH-R6 ili -SO2NH-(C1-C6)alkila, R6 ili R7;R5 zajedno sa Azotnim atomom na kojeg je spojen formira zasi eni ili nezasi eni (C3-C6)- lani prsten, koji mo e dodatno da sadr i 1-2 heteroatoma izabrana iz O, N ili S, a koji mogu da budu ponekad supstituisani sa jednim ili više supstituenata izabrana iz okso, -COOH, halo,-OH, -O-(C1-C6)alkila ili -(C1-C6)alkila;R6 je izabran iz fenila ili 5-8- lanog heteroarila koji sadr i 1-4 heteroatoma izabrana iz O, N ili S, a gde pomenuti heteroarilni ili fenilni prstenje ponekad supstituisan sa jednim ili više supstituenata izabrana iz halogena, -OH, -O-(C1-C6)alkila, -perhaloalkila, -(C1-C6)alkila, -(C3-C6)cikloalkila, -SO2(C1-C6)alkila, cijano, -COOH, -C(O)O-(C,-C6)alkila, -C(O)O-CH2-arila, C(O)O-arila, -CONH(C1-C3)alkila, nitro, -NH2, -NH-(C1-C6)alkila, -NHC(O)- (C,-C6)alkila, -NHC(O)-arila, -NHSO2(C1-C5)alkila. -CONH2, -SO2-(C1-C6)alkila, - NHSO2(C1-C6)alkila ili -COR8;R7 je 3-6- lani heterocikli ki prs
The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL COMPOUNDS |
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