NEW PIPERAZINE DERIVATIVES OF DIALKYL OXINDOLES
The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionall...
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| creator | LEVELEKI CSILLA FLORIAN ENDRENE KAPILLERNE DEZSOFI RITA GACSALYI ISTVAN VOLK BALAZS MEZEI TIBOR EGYED ANDRAS SZENASI GABOR SZIRAY NORA MORICZ KRISZTINA BARKOCZY JOZSEF GIGLER GABOR PALLAGI KATALIN LEVAY GYORGY SIMIG GYULA HARSING LASZLO GABOR |
| description | The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.
Predmetni pronalazak obezbeđuje nove 3,3-disupstituisane indol-2-on derivate opšte formule (I), koji su korisni u tretmanu i/ili profilaksi oboljenja centralnog nervnog sistema, gastrointestinalnog sistema i kardiovaskulamog sistema. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_RS20060623A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>RS20060623A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_RS20060623A3</originalsourceid><addsrcrecordid>eNrjZND3cw1XCPAMcA1yjPL0c1VwcQ3yDHMM8QxzDVbwd1Nw8XT08Y70UfCP8PRz8fdxDeZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfFBwUYGBmYGZkbGjsZEKAEA1cwl3Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NEW PIPERAZINE DERIVATIVES OF DIALKYL OXINDOLES</title><source>esp@cenet</source><creator>LEVELEKI CSILLA ; FLORIAN ENDRENE ; KAPILLERNE DEZSOFI RITA ; GACSALYI ISTVAN ; VOLK BALAZS ; MEZEI TIBOR ; EGYED ANDRAS ; SZENASI GABOR ; SZIRAY NORA ; MORICZ KRISZTINA ; BARKOCZY JOZSEF ; GIGLER GABOR ; PALLAGI KATALIN ; LEVAY GYORGY ; SIMIG GYULA ; HARSING LASZLO GABOR</creator><creatorcontrib>LEVELEKI CSILLA ; FLORIAN ENDRENE ; KAPILLERNE DEZSOFI RITA ; GACSALYI ISTVAN ; VOLK BALAZS ; MEZEI TIBOR ; EGYED ANDRAS ; SZENASI GABOR ; SZIRAY NORA ; MORICZ KRISZTINA ; BARKOCZY JOZSEF ; GIGLER GABOR ; PALLAGI KATALIN ; LEVAY GYORGY ; SIMIG GYULA ; HARSING LASZLO GABOR</creatorcontrib><description>The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.
Predmetni pronalazak obezbeđuje nove 3,3-disupstituisane indol-2-on derivate opšte formule (I), koji su korisni u tretmanu i/ili profilaksi oboljenja centralnog nervnog sistema, gastrointestinalnog sistema i kardiovaskulamog sistema.</description><language>eng ; srp</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080929&DB=EPODOC&CC=RS&NR=20060623A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080929&DB=EPODOC&CC=RS&NR=20060623A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEVELEKI CSILLA</creatorcontrib><creatorcontrib>FLORIAN ENDRENE</creatorcontrib><creatorcontrib>KAPILLERNE DEZSOFI RITA</creatorcontrib><creatorcontrib>GACSALYI ISTVAN</creatorcontrib><creatorcontrib>VOLK BALAZS</creatorcontrib><creatorcontrib>MEZEI TIBOR</creatorcontrib><creatorcontrib>EGYED ANDRAS</creatorcontrib><creatorcontrib>SZENASI GABOR</creatorcontrib><creatorcontrib>SZIRAY NORA</creatorcontrib><creatorcontrib>MORICZ KRISZTINA</creatorcontrib><creatorcontrib>BARKOCZY JOZSEF</creatorcontrib><creatorcontrib>GIGLER GABOR</creatorcontrib><creatorcontrib>PALLAGI KATALIN</creatorcontrib><creatorcontrib>LEVAY GYORGY</creatorcontrib><creatorcontrib>SIMIG GYULA</creatorcontrib><creatorcontrib>HARSING LASZLO GABOR</creatorcontrib><title>NEW PIPERAZINE DERIVATIVES OF DIALKYL OXINDOLES</title><description>The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.
Predmetni pronalazak obezbeđuje nove 3,3-disupstituisane indol-2-on derivate opšte formule (I), koji su korisni u tretmanu i/ili profilaksi oboljenja centralnog nervnog sistema, gastrointestinalnog sistema i kardiovaskulamog sistema.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND3cw1XCPAMcA1yjPL0c1VwcQ3yDHMM8QxzDVbwd1Nw8XT08Y70UfCP8PRz8fdxDeZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfFBwUYGBmYGZkbGjsZEKAEA1cwl3Q</recordid><startdate>20080929</startdate><enddate>20080929</enddate><creator>LEVELEKI CSILLA</creator><creator>FLORIAN ENDRENE</creator><creator>KAPILLERNE DEZSOFI RITA</creator><creator>GACSALYI ISTVAN</creator><creator>VOLK BALAZS</creator><creator>MEZEI TIBOR</creator><creator>EGYED ANDRAS</creator><creator>SZENASI GABOR</creator><creator>SZIRAY NORA</creator><creator>MORICZ KRISZTINA</creator><creator>BARKOCZY JOZSEF</creator><creator>GIGLER GABOR</creator><creator>PALLAGI KATALIN</creator><creator>LEVAY GYORGY</creator><creator>SIMIG GYULA</creator><creator>HARSING LASZLO GABOR</creator><scope>EVB</scope></search><sort><creationdate>20080929</creationdate><title>NEW PIPERAZINE DERIVATIVES OF DIALKYL OXINDOLES</title><author>LEVELEKI CSILLA ; FLORIAN ENDRENE ; KAPILLERNE DEZSOFI RITA ; GACSALYI ISTVAN ; VOLK BALAZS ; MEZEI TIBOR ; EGYED ANDRAS ; SZENASI GABOR ; SZIRAY NORA ; MORICZ KRISZTINA ; BARKOCZY JOZSEF ; GIGLER GABOR ; PALLAGI KATALIN ; LEVAY GYORGY ; SIMIG GYULA ; HARSING LASZLO GABOR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RS20060623A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; srp</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LEVELEKI CSILLA</creatorcontrib><creatorcontrib>FLORIAN ENDRENE</creatorcontrib><creatorcontrib>KAPILLERNE DEZSOFI RITA</creatorcontrib><creatorcontrib>GACSALYI ISTVAN</creatorcontrib><creatorcontrib>VOLK BALAZS</creatorcontrib><creatorcontrib>MEZEI TIBOR</creatorcontrib><creatorcontrib>EGYED ANDRAS</creatorcontrib><creatorcontrib>SZENASI GABOR</creatorcontrib><creatorcontrib>SZIRAY NORA</creatorcontrib><creatorcontrib>MORICZ KRISZTINA</creatorcontrib><creatorcontrib>BARKOCZY JOZSEF</creatorcontrib><creatorcontrib>GIGLER GABOR</creatorcontrib><creatorcontrib>PALLAGI KATALIN</creatorcontrib><creatorcontrib>LEVAY GYORGY</creatorcontrib><creatorcontrib>SIMIG GYULA</creatorcontrib><creatorcontrib>HARSING LASZLO GABOR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEVELEKI CSILLA</au><au>FLORIAN ENDRENE</au><au>KAPILLERNE DEZSOFI RITA</au><au>GACSALYI ISTVAN</au><au>VOLK BALAZS</au><au>MEZEI TIBOR</au><au>EGYED ANDRAS</au><au>SZENASI GABOR</au><au>SZIRAY NORA</au><au>MORICZ KRISZTINA</au><au>BARKOCZY JOZSEF</au><au>GIGLER GABOR</au><au>PALLAGI KATALIN</au><au>LEVAY GYORGY</au><au>SIMIG GYULA</au><au>HARSING LASZLO GABOR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NEW PIPERAZINE DERIVATIVES OF DIALKYL OXINDOLES</title><date>2008-09-29</date><risdate>2008</risdate><abstract>The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.
Predmetni pronalazak obezbeđuje nove 3,3-disupstituisane indol-2-on derivate opšte formule (I), koji su korisni u tretmanu i/ili profilaksi oboljenja centralnog nervnog sistema, gastrointestinalnog sistema i kardiovaskulamog sistema.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NEW PIPERAZINE DERIVATIVES OF DIALKYL OXINDOLES |
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