PROCESS FOR PREPARING A NEW CRYSTALLINE ATORVASTATIN HEMICALCIUM SALT POLYMORPH FORM
The invention relates to a new crystalline polymorph form of atorvastatin hemicalcium salt [calcium salt of (3R, 5R)-7 - [3-phenyl-4- (phenyl carbamoyl) -2- (4 -fluorophenyl) -5- (1-methylethyl) -1H-pyrrol-1-yl] -3, 5-dihydroxy-heptanoic acid (2:1)], to medicinal preparations containing the new poly...
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| creator | BARTHA FERENC NAGY KALMAN BARKOCZY JOZSEF KOTAY NAGY PETER CSELENYAK JUDIT KATONA ZOLTAN RUZSICS GYORGY VERECZKEYNE DONATH GYORGYI SIMIG GYULA NEMETH NORBERT SZENT-KIRALLYI ZSUZSANNA |
| description | The invention relates to a new crystalline polymorph form of atorvastatin hemicalcium salt [calcium salt of (3R, 5R)-7 - [3-phenyl-4- (phenyl carbamoyl) -2- (4 -fluorophenyl) -5- (1-methylethyl) -1H-pyrrol-1-yl] -3, 5-dihydroxy-heptanoic acid (2:1)], to medicinal preparations containing the new polymorph form, to a process for the preparation thereof and the use of the new polymorph form. The claimed polymorph form has an X-ray diffractogram, as presented in Figure 1.
Invenţia se referă la o formă polimorfă, cristalină, a sării hemicalcice a atorvastatinului [sarea de calciu a acidului (3R,5R)-7-[3-fenil-4-(fenilcarbamoil)-2-(4-fluorfenil)-5-(1-metiletil)-1H-pirol-1-il]-3,5-dihidroxiheptanoic (2:1)], la preparatele medicinale care o conţin, la un procedeu de preparare a acesteia şi la utilizarea acestei forme polimorfe. Forma polimorfă conform invenţiei are o difractogramă cu raze X, prezentată în fig. 1. |
| format | Patent |
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Invenţia se referă la o formă polimorfă, cristalină, a sării hemicalcice a atorvastatinului [sarea de calciu a acidului (3R,5R)-7-[3-fenil-4-(fenilcarbamoil)-2-(4-fluorfenil)-5-(1-metiletil)-1H-pirol-1-il]-3,5-dihidroxiheptanoic (2:1)], la preparatele medicinale care o conţin, la un procedeu de preparare a acesteia şi la utilizarea acestei forme polimorfe. Forma polimorfă conform invenţiei are o difractogramă cu raze X, prezentată în fig. 1.</description><language>eng ; rum</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150730&DB=EPODOC&CC=RO&NR=200700700A8$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150730&DB=EPODOC&CC=RO&NR=200700700A8$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BARTHA FERENC</creatorcontrib><creatorcontrib>NAGY KALMAN</creatorcontrib><creatorcontrib>BARKOCZY JOZSEF</creatorcontrib><creatorcontrib>KOTAY NAGY PETER</creatorcontrib><creatorcontrib>CSELENYAK JUDIT</creatorcontrib><creatorcontrib>KATONA ZOLTAN</creatorcontrib><creatorcontrib>RUZSICS GYORGY</creatorcontrib><creatorcontrib>VERECZKEYNE DONATH GYORGYI</creatorcontrib><creatorcontrib>SIMIG GYULA</creatorcontrib><creatorcontrib>NEMETH NORBERT</creatorcontrib><creatorcontrib>SZENT-KIRALLYI ZSUZSANNA</creatorcontrib><title>PROCESS FOR PREPARING A NEW CRYSTALLINE ATORVASTATIN HEMICALCIUM SALT POLYMORPH FORM</title><description>The invention relates to a new crystalline polymorph form of atorvastatin hemicalcium salt [calcium salt of (3R, 5R)-7 - [3-phenyl-4- (phenyl carbamoyl) -2- (4 -fluorophenyl) -5- (1-methylethyl) -1H-pyrrol-1-yl] -3, 5-dihydroxy-heptanoic acid (2:1)], to medicinal preparations containing the new polymorph form, to a process for the preparation thereof and the use of the new polymorph form. The claimed polymorph form has an X-ray diffractogram, as presented in Figure 1.
Invenţia se referă la o formă polimorfă, cristalină, a sării hemicalcice a atorvastatinului [sarea de calciu a acidului (3R,5R)-7-[3-fenil-4-(fenilcarbamoil)-2-(4-fluorfenil)-5-(1-metiletil)-1H-pirol-1-il]-3,5-dihidroxiheptanoic (2:1)], la preparatele medicinale care o conţin, la un procedeu de preparare a acesteia şi la utilizarea acestei forme polimorfe. Forma polimorfă conform invenţiei are o difractogramă cu raze X, prezentată în fig. 1.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAgJCPJ3dg0OVnDzD1IICHINcAzy9HNXcFTwcw1XcA6KDA5x9PHx9HNVcAzxDwpzBHJDPP0UPFx9PZ0dfZw9Q30Vgh19QhQC_H0iff2DAjxA5vjyMLCmJeYUp_JCaW4GJTfXEGcP3dSC_PjU4oLE5NS81JL4IH8jAwNzMHK0MCZKEQDEGDED</recordid><startdate>20150730</startdate><enddate>20150730</enddate><creator>BARTHA FERENC</creator><creator>NAGY KALMAN</creator><creator>BARKOCZY JOZSEF</creator><creator>KOTAY NAGY PETER</creator><creator>CSELENYAK JUDIT</creator><creator>KATONA ZOLTAN</creator><creator>RUZSICS GYORGY</creator><creator>VERECZKEYNE DONATH GYORGYI</creator><creator>SIMIG GYULA</creator><creator>NEMETH NORBERT</creator><creator>SZENT-KIRALLYI ZSUZSANNA</creator><scope>EVB</scope></search><sort><creationdate>20150730</creationdate><title>PROCESS FOR PREPARING A NEW CRYSTALLINE ATORVASTATIN HEMICALCIUM SALT POLYMORPH FORM</title><author>BARTHA FERENC ; NAGY KALMAN ; BARKOCZY JOZSEF ; KOTAY NAGY PETER ; CSELENYAK JUDIT ; KATONA ZOLTAN ; RUZSICS GYORGY ; VERECZKEYNE DONATH GYORGYI ; SIMIG GYULA ; NEMETH NORBERT ; SZENT-KIRALLYI ZSUZSANNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RO200700700A83</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rum</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BARTHA FERENC</creatorcontrib><creatorcontrib>NAGY KALMAN</creatorcontrib><creatorcontrib>BARKOCZY JOZSEF</creatorcontrib><creatorcontrib>KOTAY NAGY PETER</creatorcontrib><creatorcontrib>CSELENYAK JUDIT</creatorcontrib><creatorcontrib>KATONA ZOLTAN</creatorcontrib><creatorcontrib>RUZSICS GYORGY</creatorcontrib><creatorcontrib>VERECZKEYNE DONATH GYORGYI</creatorcontrib><creatorcontrib>SIMIG GYULA</creatorcontrib><creatorcontrib>NEMETH NORBERT</creatorcontrib><creatorcontrib>SZENT-KIRALLYI ZSUZSANNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BARTHA FERENC</au><au>NAGY KALMAN</au><au>BARKOCZY JOZSEF</au><au>KOTAY NAGY PETER</au><au>CSELENYAK JUDIT</au><au>KATONA ZOLTAN</au><au>RUZSICS GYORGY</au><au>VERECZKEYNE DONATH GYORGYI</au><au>SIMIG GYULA</au><au>NEMETH NORBERT</au><au>SZENT-KIRALLYI ZSUZSANNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PREPARING A NEW CRYSTALLINE ATORVASTATIN HEMICALCIUM SALT POLYMORPH FORM</title><date>2015-07-30</date><risdate>2015</risdate><abstract>The invention relates to a new crystalline polymorph form of atorvastatin hemicalcium salt [calcium salt of (3R, 5R)-7 - [3-phenyl-4- (phenyl carbamoyl) -2- (4 -fluorophenyl) -5- (1-methylethyl) -1H-pyrrol-1-yl] -3, 5-dihydroxy-heptanoic acid (2:1)], to medicinal preparations containing the new polymorph form, to a process for the preparation thereof and the use of the new polymorph form. The claimed polymorph form has an X-ray diffractogram, as presented in Figure 1.
Invenţia se referă la o formă polimorfă, cristalină, a sării hemicalcice a atorvastatinului [sarea de calciu a acidului (3R,5R)-7-[3-fenil-4-(fenilcarbamoil)-2-(4-fluorfenil)-5-(1-metiletil)-1H-pirol-1-il]-3,5-dihidroxiheptanoic (2:1)], la preparatele medicinale care o conţin, la un procedeu de preparare a acesteia şi la utilizarea acestei forme polimorfe. Forma polimorfă conform invenţiei are o difractogramă cu raze X, prezentată în fig. 1.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PROCESS FOR PREPARING A NEW CRYSTALLINE ATORVASTATIN HEMICALCIUM SALT POLYMORPH FORM |
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