PROCESSO PARA A PREPARACAO DE NOVOS 4(5)-IMIDAZOIS QUE INIBEM A AROMATASE
Novel imidazole derivatives of the formula wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H, CH3, C2H5, C3H7, OCH3, OH, CH2OH, NO2, NH2, CN, CF3, CHF2, CH2F or halogen; R min is H or where R3 is H, CH3 or halogen; R4 is H, R5 is H or OH, R6 is H or OH and R7 is H or R4...
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| creator | RISTO ARVO SAKARI LAMMINTAUSTA ARJA LEENA KARJALAINEN MARJA-LIISA SODERVALL ARTO JOHANNES KARJALAINEN MATTI ANTERO LAHDE ARJA MARKETTA KALAPUDAS REINO OLAVI PELKONEN |
| description | Novel imidazole derivatives of the formula wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H, CH3, C2H5, C3H7, OCH3, OH, CH2OH, NO2, NH2, CN, CF3, CHF2, CH2F or halogen; R min is H or where R3 is H, CH3 or halogen; R4 is H, R5 is H or OH, R6 is H or OH and R7 is H or R4 and R6 together form a bond or R5 and R7 together form a bond; X and Y, which can be the same or different, are a bond, a straight C1-2-alkyl or the corresponding alkenyl and z is 0 to 2 and wherein R1, R2, R min 1, R min 2 and R min are as defined before, R4 is H or OH and R5 is H or R4 and R5 together form a bond and y is 0 to 4, and their non-toxic salts exhibit aromatase and desmolase inhibiting properties. Very selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer. |
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Very selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer.</description><edition>6</edition><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960830&DB=EPODOC&CC=PT&NR=93606B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960830&DB=EPODOC&CC=PT&NR=93606B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RISTO ARVO SAKARI LAMMINTAUSTA</creatorcontrib><creatorcontrib>ARJA LEENA KARJALAINEN</creatorcontrib><creatorcontrib>MARJA-LIISA SODERVALL</creatorcontrib><creatorcontrib>ARTO JOHANNES KARJALAINEN</creatorcontrib><creatorcontrib>MATTI ANTERO LAHDE</creatorcontrib><creatorcontrib>ARJA MARKETTA KALAPUDAS</creatorcontrib><creatorcontrib>REINO OLAVI PELKONEN</creatorcontrib><title>PROCESSO PARA A PREPARACAO DE NOVOS 4(5)-IMIDAZOIS QUE INIBEM A AROMATASE</title><description>Novel imidazole derivatives of the formula wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H, CH3, C2H5, C3H7, OCH3, OH, CH2OH, NO2, NH2, CN, CF3, CHF2, CH2F or halogen; R min is H or where R3 is H, CH3 or halogen; R4 is H, R5 is H or OH, R6 is H or OH and R7 is H or R4 and R6 together form a bond or R5 and R7 together form a bond; X and Y, which can be the same or different, are a bond, a straight C1-2-alkyl or the corresponding alkenyl and z is 0 to 2 and wherein R1, R2, R min 1, R min 2 and R min are as defined before, R4 is H or OH and R5 is H or R4 and R5 together form a bond and y is 0 to 4, and their non-toxic salts exhibit aromatase and desmolase inhibiting properties. Very selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAMCPJ3dg0O9lcIcAxyVHBUCAhyBbGcHf0VXFwV_PzD_IMVTDRMNXU9fT1dHKP8PYMVAkNdFTz9PJ1cfYHqHYP8fR1DHINdeRhY0xJzilN5oTQ3g6yba4izh25qQX58anFBYnJqXmpJfECIpbGZgZmTMSF5AIL6Ktw</recordid><startdate>19960830</startdate><enddate>19960830</enddate><creator>RISTO ARVO SAKARI LAMMINTAUSTA</creator><creator>ARJA LEENA KARJALAINEN</creator><creator>MARJA-LIISA SODERVALL</creator><creator>ARTO JOHANNES KARJALAINEN</creator><creator>MATTI ANTERO LAHDE</creator><creator>ARJA MARKETTA KALAPUDAS</creator><creator>REINO OLAVI PELKONEN</creator><scope>EVB</scope></search><sort><creationdate>19960830</creationdate><title>PROCESSO PARA A PREPARACAO DE NOVOS 4(5)-IMIDAZOIS QUE INIBEM A AROMATASE</title><author>RISTO ARVO SAKARI LAMMINTAUSTA ; ARJA LEENA KARJALAINEN ; MARJA-LIISA SODERVALL ; ARTO JOHANNES KARJALAINEN ; MATTI ANTERO LAHDE ; ARJA MARKETTA KALAPUDAS ; REINO OLAVI PELKONEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PT93606B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>1996</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RISTO ARVO SAKARI LAMMINTAUSTA</creatorcontrib><creatorcontrib>ARJA LEENA KARJALAINEN</creatorcontrib><creatorcontrib>MARJA-LIISA SODERVALL</creatorcontrib><creatorcontrib>ARTO JOHANNES KARJALAINEN</creatorcontrib><creatorcontrib>MATTI ANTERO LAHDE</creatorcontrib><creatorcontrib>ARJA MARKETTA KALAPUDAS</creatorcontrib><creatorcontrib>REINO OLAVI PELKONEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RISTO ARVO SAKARI LAMMINTAUSTA</au><au>ARJA LEENA KARJALAINEN</au><au>MARJA-LIISA SODERVALL</au><au>ARTO JOHANNES KARJALAINEN</au><au>MATTI ANTERO LAHDE</au><au>ARJA MARKETTA KALAPUDAS</au><au>REINO OLAVI PELKONEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESSO PARA A PREPARACAO DE NOVOS 4(5)-IMIDAZOIS QUE INIBEM A AROMATASE</title><date>1996-08-30</date><risdate>1996</risdate><abstract>Novel imidazole derivatives of the formula wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H, CH3, C2H5, C3H7, OCH3, OH, CH2OH, NO2, NH2, CN, CF3, CHF2, CH2F or halogen; R min is H or where R3 is H, CH3 or halogen; R4 is H, R5 is H or OH, R6 is H or OH and R7 is H or R4 and R6 together form a bond or R5 and R7 together form a bond; X and Y, which can be the same or different, are a bond, a straight C1-2-alkyl or the corresponding alkenyl and z is 0 to 2 and wherein R1, R2, R min 1, R min 2 and R min are as defined before, R4 is H or OH and R5 is H or R4 and R5 together form a bond and y is 0 to 4, and their non-toxic salts exhibit aromatase and desmolase inhibiting properties. Very selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESSO PARA A PREPARACAO DE NOVOS 4(5)-IMIDAZOIS QUE INIBEM A AROMATASE |
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