PROCESSO PARA A PREPARACAO DE POLIPEPTIDEO PE40 MODIFICADO
The present invention provides modifications of the PE40 domain which eliminate the chemical ambiguities caused by the cysteines in PE40. Substitution of other amino acids such as, e.g., alanine for the cysteine residues in PE40, or deletion of two or more of the cysteine residues improves the biolo...
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| creator | STEVEN M. STIRDIVANT MARK W. RIEMEN |
| description | The present invention provides modifications of the PE40 domain which eliminate the chemical ambiguities caused by the cysteines in PE40. Substitution of other amino acids such as, e.g., alanine for the cysteine residues in PE40, or deletion of two or more of the cysteine residues improves the biological and chemical properties of conjugates formed between modified PE40 and a targeting agent. |
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Substitution of other amino acids such as, e.g., alanine for the cysteine residues in PE40, or deletion of two or more of the cysteine residues improves the biological and chemical properties of conjugates formed between modified PE40 and a targeting agent.</description><edition>6</edition><language>por</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960830&DB=EPODOC&CC=PT&NR=93525B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960830&DB=EPODOC&CC=PT&NR=93525B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STEVEN M. STIRDIVANT</creatorcontrib><creatorcontrib>MARK W. RIEMEN</creatorcontrib><title>PROCESSO PARA A PREPARACAO DE POLIPEPTIDEO PE40 MODIFICADO</title><description>The present invention provides modifications of the PE40 domain which eliminate the chemical ambiguities caused by the cysteines in PE40. Substitution of other amino acids such as, e.g., alanine for the cysteine residues in PE40, or deletion of two or more of the cysteine residues improves the biological and chemical properties of conjugates formed between modified PE40 and a targeting agent.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAKCPJ3dg0O9lcIcAxyVHBUCAhyBbGcHf0VXFwVAvx9PANcA0I8XVyBKlxNDBR8_V083TydHV38eRhY0xJzilN5oTQ3g6yba4izh25qQX58anFBYnJqXmpJfECIpbGpkamTMSF5AFXaJyE</recordid><startdate>19960830</startdate><enddate>19960830</enddate><creator>STEVEN M. 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STIRDIVANT</creatorcontrib><creatorcontrib>MARK W. RIEMEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>STEVEN M. STIRDIVANT</au><au>MARK W. RIEMEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESSO PARA A PREPARACAO DE POLIPEPTIDEO PE40 MODIFICADO</title><date>1996-08-30</date><risdate>1996</risdate><abstract>The present invention provides modifications of the PE40 domain which eliminate the chemical ambiguities caused by the cysteines in PE40. Substitution of other amino acids such as, e.g., alanine for the cysteine residues in PE40, or deletion of two or more of the cysteine residues improves the biological and chemical properties of conjugates formed between modified PE40 and a targeting agent.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | PROCESSO PARA A PREPARACAO DE POLIPEPTIDEO PE40 MODIFICADO |
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