PROCESSO PARA A PREPARACAO DE NOVOS DERIVADOS DA QUINOLONA TERAPEUTICAMENTE ACTIVOS
Quinolone sulphonates of formula I in which R1 is lower alkyl; R2 is lower alkyl; and R3, R4 and R5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, halo, halogenated lower alkyl, halogenated lower alkoxy, cyan...
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creator | ROY VICTOR DAVIES NICHOLAS JOHN HOLMAN MICHAEL DONALD BROWN |
description | Quinolone sulphonates of formula I in which R1 is lower alkyl; R2 is lower alkyl; and R3, R4 and R5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, halo, halogenated lower alkyl, halogenated lower alkoxy, cyano, phenyl or phenyl substituted by 1 or 2 groups independently selected from lower alkyl, lower alkoxy and halo, have antihypertensive activity. Processes for preparing compounds of formula I and pharmaceutical compositions containing them are described. Compounds of formula I are also indicated for use in the treatment of heart failure and ischaemic heart disease. |
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Processes for preparing compounds of formula I and pharmaceutical compositions containing them are described. Compounds of formula I are also indicated for use in the treatment of heart failure and ischaemic heart disease.</description><edition>4</edition><language>por</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19891004&DB=EPODOC&CC=PT&NR=89794A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19891004&DB=EPODOC&CC=PT&NR=89794A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ROY VICTOR DAVIES</creatorcontrib><creatorcontrib>NICHOLAS JOHN HOLMAN</creatorcontrib><creatorcontrib>MICHAEL DONALD BROWN</creatorcontrib><title>PROCESSO PARA A PREPARACAO DE NOVOS DERIVADOS DA QUINOLONA TERAPEUTICAMENTE ACTIVOS</title><description>Quinolone sulphonates of formula I in which R1 is lower alkyl; R2 is lower alkyl; and R3, R4 and R5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, halo, halogenated lower alkyl, halogenated lower alkoxy, cyano, phenyl or phenyl substituted by 1 or 2 groups independently selected from lower alkyl, lower alkoxy and halo, have antihypertensive activity. Processes for preparing compounds of formula I and pharmaceutical compositions containing them are described. Compounds of formula I are also indicated for use in the treatment of heart failure and ischaemic heart disease.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyrEKwjAUheEsDqI-gnBfwElBOx7SWwxobkxuu5ZS4iS1UN8fW3B3Oh-cf21SiGI5JaGACAKFyIsshEomL42kGdE1KBeBHrXzchMPUo4IXKuzuLNXJlh1c781q2f3mvLutxuzr1jt9ZDHd5unsevzkD9t0EtxLk44_vu_lrIulg</recordid><startdate>19891004</startdate><enddate>19891004</enddate><creator>ROY VICTOR DAVIES</creator><creator>NICHOLAS JOHN HOLMAN</creator><creator>MICHAEL DONALD BROWN</creator><scope>EVB</scope></search><sort><creationdate>19891004</creationdate><title>PROCESSO PARA A PREPARACAO DE NOVOS DERIVADOS DA QUINOLONA TERAPEUTICAMENTE ACTIVOS</title><author>ROY VICTOR DAVIES ; NICHOLAS JOHN HOLMAN ; MICHAEL DONALD BROWN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PT89794A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>1989</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ROY VICTOR DAVIES</creatorcontrib><creatorcontrib>NICHOLAS JOHN HOLMAN</creatorcontrib><creatorcontrib>MICHAEL DONALD BROWN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ROY VICTOR DAVIES</au><au>NICHOLAS JOHN HOLMAN</au><au>MICHAEL DONALD BROWN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESSO PARA A PREPARACAO DE NOVOS DERIVADOS DA QUINOLONA TERAPEUTICAMENTE ACTIVOS</title><date>1989-10-04</date><risdate>1989</risdate><abstract>Quinolone sulphonates of formula I in which R1 is lower alkyl; R2 is lower alkyl; and R3, R4 and R5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, halo, halogenated lower alkyl, halogenated lower alkoxy, cyano, phenyl or phenyl substituted by 1 or 2 groups independently selected from lower alkyl, lower alkoxy and halo, have antihypertensive activity. Processes for preparing compounds of formula I and pharmaceutical compositions containing them are described. Compounds of formula I are also indicated for use in the treatment of heart failure and ischaemic heart disease.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | PROCESSO PARA A PREPARACAO DE NOVOS DERIVADOS DA QUINOLONA TERAPEUTICAMENTE ACTIVOS |
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