PROCESS FOR THE PREPARATION OF 1-<<2-<5-DIMETHYLAMINOETHYL-2- (FURYLMETHYLTHIO)-ETHYL>>>-AMINO-1-METHYLAMINO-2-NITROETHYLENE AND HYDROCHLORIDE THEREOF

1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-amino-1-methyl amino-2 - nitroethylene of the formula (I> and its hydrochloride, are prepared by reacting an 1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-amino-1-(subst ituted thio)-2- nitroethylene of the formula (VI), wherein R...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	PETER MATYUS, NANDOR MAKK, EMILIA USKERT, ENDRE KASZTREINER, LAJOS TOLDY, ARPAD LAZAR, TIBOR BALOGH, TIBOR SOMOGYI, TIBOR LANG, BELA STEFKO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-amino-1-methyl amino-2 - nitroethylene of the formula (I> and its hydrochloride, are prepared by reacting an 1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-amino-1-(subst ituted thio)-2- nitroethylene of the formula (VI), wherein R represents an optionally substituted C1-4 alkyl group or an oxoalkyl, aryl, aralkyl, or oxoaralkyl group, with an agent capable of splitting off a mercapten, in an organic solvent, optionally in the presence of an acid-binding agent, then reacting the in situ prepared 1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-3-nitroketenei mine of the formula (VII> with methylamine and finally, if desired, separating the obtained base of formula (I), purifying it and/or, if desired, transforming it to its hydrochloric salt.